KTX25_TITSE
ID KTX25_TITSE Reviewed; 59 AA.
AC A0A218QWZ7;
DT 03-AUG-2022, integrated into UniProtKB/Swiss-Prot.
DT 27-SEP-2017, sequence version 1.
DT 03-AUG-2022, entry version 13.
DE RecName: Full=Putative potassium channel toxin Ts25 {ECO:0000305};
DE AltName: Full=Putative KTx {ECO:0000305};
DE AltName: Full=Tityustoxin-25 {ECO:0000305};
DE Flags: Precursor;
OS Tityus serrulatus (Brazilian scorpion).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Chelicerata; Arachnida;
OC Scorpiones; Buthida; Buthoidea; Buthidae; Tityus.
OX NCBI_TaxID=6887;
RN [1] {ECO:0000312|EMBL:JAW07012.1}
RP NUCLEOTIDE SEQUENCE [MRNA].
RC TISSUE=Telson;
RX PubMed=29561852; DOI=10.1371/journal.pone.0193739;
RA de Oliveira U.C., Nishiyama M.Y. Jr., Dos Santos M.B.V.,
RA Santos-da-Silva A.P., Chalkidis H.M., Souza-Imberg A., Candido D.M.,
RA Yamanouye N., Dorce V.A.C., Junqueira-de-Azevedo I.L.M.;
RT "Proteomic endorsed transcriptomic profiles of venom glands from Tityus
RT obscurus and T. serrulatus scorpions.";
RL PLoS ONE 13:e0193739-e0193739(2018).
CC -!- FUNCTION: Potently blocks Kv1.1/KCNA1 (85%), Kv1.2/KCNA2 (91%),
CC Kv1.3/KCNA3 (89%), Kv1.6/KCNA6 (94%), and Shaker (97%).
CC {ECO:0000250|UniProtKB:P46114}.
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000305|PubMed:29561852}.
CC -!- TISSUE SPECIFICITY: Expressed by the venom gland.
CC {ECO:0000305|PubMed:29561852}.
CC -!- DOMAIN: Has the structural arrangement of an alpha-helix connected to a
CC beta-sheet by disulfide bonds (CSalpha/beta).
CC {ECO:0000250|UniProtKB:P46114}.
CC -!- SIMILARITY: Belongs to the short scorpion toxin superfamily. Potassium
CC channel inhibitor family. Alpha-KTx 04 subfamily. {ECO:0000305}.
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DR EMBL; GEUW01000033; JAW07012.1; -; mRNA.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR GO; GO:0008200; F:ion channel inhibitor activity; IEA:InterPro.
DR Gene3D; 3.30.30.10; -; 1.
DR InterPro; IPR036574; Scorpion_toxin-like_sf.
DR InterPro; IPR001947; Scorpion_toxinS_K_inh.
DR Pfam; PF00451; Toxin_2; 1.
DR SUPFAM; SSF57095; SSF57095; 1.
PE 3: Inferred from homology;
KW Disulfide bond; Ion channel impairing toxin; Neurotoxin;
KW Potassium channel impairing toxin; Secreted; Signal; Toxin;
KW Voltage-gated potassium channel impairing toxin.
FT SIGNAL 1..22
FT /evidence="ECO:0000255"
FT CHAIN 23..59
FT /note="Putative potassium channel toxin Ts25"
FT /id="PRO_5012103573"
FT SITE 49
FT /note="Basic residue of the functional dyad"
FT /evidence="ECO:0000250|UniProtKB:O46028"
FT SITE 58
FT /note="Aromatic residue of the functional dyad"
FT /evidence="ECO:0000250|UniProtKB:O46028"
FT DISULFID 29..50
FT /evidence="ECO:0000250|UniProtKB:P46114"
FT DISULFID 35..55
FT /evidence="ECO:0000250|UniProtKB:P46114"
FT DISULFID 39..57
FT /evidence="ECO:0000250|UniProtKB:P46114"
SQ SEQUENCE 59 AA; 6612 MW; B2EEEAF39C501A67 CRC64;
MKAFYGILII FILISMIHLS QQVFINATCT VTSQCRPKCI EAIGQAASKC INRKCKCYP