ID   KTXG_KLULA              Reviewed;         249 AA.
AC   P09807;
DT   01-JUL-1989, integrated into UniProtKB/Swiss-Prot.
DT   01-JUL-1989, sequence version 1.
DT   25-MAY-2022, entry version 59.
DE   RecName: Full=Killer toxin subunit gamma;
DE   AltName: Full=RF3 protein;
DE   Flags: Precursor;
OS   Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 /
OS   NRRL Y-1140 / WM37) (Yeast) (Candida sphaerica).
OG   Plasmid pGKl-1.
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC   Saccharomycetales; Saccharomycetaceae; Kluyveromyces.
OX   NCBI_TaxID=284590;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=ATCC 76492 / CBS 2359/152 / CLIB 210;
RX   DOI=10.1007/BF00436963;
RA   Sor F., Fukuhara H.;
RT   "Structure of a linear plasmid of the yeast Kluyveromyces lactis; compact
RT   organization of the killer genome.";
RL   Curr. Genet. 9:147-155(1985).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37;
RX   PubMed=6473099; DOI=10.1093/nar/12.15.6011;
RA   Stark M.J.R., Mileham A.J., Romanos M.A., Boyd A.;
RT   "Nucleotide sequence and transcription analysis of a linear DNA plasmid
RT   associated with the killer character of the yeast Kluyveromyces lactis.";
RL   Nucleic Acids Res. 12:6011-6030(1984).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=ATCC 52735 / 2105-1D;
RX   PubMed=6387625; DOI=10.1093/nar/12.19.7581;
RA   Hishinuma F., Nakamura K., Hirai K., Nishizawa R., Gunge N., Maeda T.;
RT   "Cloning and nucleotide sequences of the linear DNA killer plasmids from
RT   yeast.";
RL   Nucleic Acids Res. 12:7581-7597(1984).
RN   [4]
RP   IDENTIFICATION OF PROTEIN, AND PROTEIN SEQUENCE OF 21-42.
RX   PubMed=3758030; DOI=10.1002/j.1460-2075.1986.tb04455.x;
RA   Stark M.J.R., Boyd A.;
RT   "The killer toxin of Kluyveromyces lactis: characterization of the toxin
RT   subunits and identification of the genes which encode them.";
RL   EMBO J. 5:1995-2002(1986).
CC   -!- FUNCTION: Killer toxin, which inhibits growth of sensitive strains in
CC       the G1 phase of the cell cycle.
CC   -!- SUBUNIT: The killer toxin is composed of three subunits: alpha, beta
CC       and gamma.
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DR   EMBL; X07127; CAA30139.1; -; Genomic_DNA.
DR   EMBL; X00762; CAA25336.1; -; Genomic_DNA.
DR   EMBL; X01095; CAA25571.1; -; Genomic_DNA.
DR   PIR; S07917; S07917.
DR   AlphaFoldDB; P09807; -.
DR   Proteomes; UP000000598; Plasmid pGKL1.
DR   GO; GO:0090729; F:toxin activity; IEA:UniProtKB-KW.
PE   1: Evidence at protein level;
KW   Direct protein sequencing; Plasmid; Reference proteome; Signal; Toxin.
FT   SIGNAL          1..20
FT                   /evidence="ECO:0000255"
FT   CHAIN           21..249
FT                   /note="Killer toxin subunit gamma"
FT                   /id="PRO_0000021571"
SQ   SEQUENCE   249 AA;  28742 MW;  697FE6AEF5F5D62C CRC64;
     MKIYHIFSVC YLITLCAAAA TTAREEFFLC YDLIRYLKQY EKTGESKLVE QTFFNSIKNL
     DINSREYMEL VYNKIAGISN ERNKFENIYK DGDSISQVVE RAVSEKKLTF GLNGKGLYVP
     ENGEPRLKGY ASIIERITLD LMEIYSIKGL NDIPRDIKFN MEKIRQERYN QMKEALNSVE
     GYKGKIVASD SDWCFKDPQG NRITDFDSIN KELGLGRRDV KLDKGHDDLI KLCTEKIDSM
     NNLQNGKCV