KU1_GEOUR
ID KU1_GEOUR Reviewed; 261 AA.
AC A5G742;
DT 24-NOV-2009, integrated into UniProtKB/Swiss-Prot.
DT 12-JUN-2007, sequence version 1.
DT 25-MAY-2022, entry version 75.
DE RecName: Full=Non-homologous end joining protein Ku 1 {ECO:0000255|HAMAP-Rule:MF_01875};
GN Name=ku1 {ECO:0000255|HAMAP-Rule:MF_01875}; OrderedLocusNames=Gura_3454;
OS Geotalea uraniireducens (strain Rf4) (Geobacter uraniireducens).
OC Bacteria; Proteobacteria; Deltaproteobacteria; Desulfuromonadales;
OC Geobacteraceae; Geotalea.
OX NCBI_TaxID=351605;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC BAA-1134 / JCM 13001 / Rf4;
RG US DOE Joint Genome Institute;
RA Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C.,
RA Glavina del Rio T., Hammon N., Israni S., Dalin E., Tice H., Pitluck S.,
RA Chertkov O., Brettin T., Bruce D., Han C., Schmutz J., Larimer F., Land M.,
RA Hauser L., Kyrpides N., Mikhailova N., Shelobolina E., Aklujkar M.,
RA Lovley D., Richardson P.;
RT "Complete sequence of Geobacter uraniireducens Rf4.";
RL Submitted (MAY-2007) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: With LigD forms a non-homologous end joining (NHEJ) DNA
CC repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds
CC linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA
CC nor ssDNA. Recruits and stimulates the ligase activity of LigD.
CC {ECO:0000255|HAMAP-Rule:MF_01875}.
CC -!- SUBUNIT: Homodimer. Interacts with LigD. {ECO:0000255|HAMAP-
CC Rule:MF_01875}.
CC -!- SIMILARITY: Belongs to the prokaryotic Ku family. {ECO:0000255|HAMAP-
CC Rule:MF_01875}.
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DR EMBL; CP000698; ABQ27610.1; -; Genomic_DNA.
DR RefSeq; WP_011940271.1; NC_009483.1.
DR AlphaFoldDB; A5G742; -.
DR SMR; A5G742; -.
DR STRING; 351605.Gura_3454; -.
DR PRIDE; A5G742; -.
DR EnsemblBacteria; ABQ27610; ABQ27610; Gura_3454.
DR KEGG; gur:Gura_3454; -.
DR HOGENOM; CLU_048975_0_1_7; -.
DR OMA; HAMRWPD; -.
DR OrthoDB; 1724780at2; -.
DR Proteomes; UP000006695; Chromosome.
DR GO; GO:0003690; F:double-stranded DNA binding; IEA:UniProtKB-UniRule.
DR GO; GO:0006310; P:DNA recombination; IEA:UniProtKB-KW.
DR GO; GO:0006303; P:double-strand break repair via nonhomologous end joining; IEA:UniProtKB-UniRule.
DR CDD; cd00789; KU_like; 1.
DR Gene3D; 2.40.290.10; -; 1.
DR HAMAP; MF_01875; Prokaryotic_Ku; 1.
DR InterPro; IPR006164; Ku70/Ku80_beta-barrel_dom.
DR InterPro; IPR009187; Prok_Ku.
DR InterPro; IPR016194; SPOC-like_C_dom_sf.
DR PANTHER; PTHR41251; PTHR41251; 1.
DR Pfam; PF02735; Ku; 1.
DR PIRSF; PIRSF006493; Prok_Ku; 1.
DR SMART; SM00559; Ku78; 1.
DR SUPFAM; SSF100939; SSF100939; 1.
DR TIGRFAMs; TIGR02772; Ku_bact; 1.
PE 3: Inferred from homology;
KW DNA damage; DNA recombination; DNA repair; DNA-binding; Reference proteome.
FT CHAIN 1..261
FT /note="Non-homologous end joining protein Ku 1"
FT /id="PRO_0000389185"
FT DOMAIN 12..171
FT /note="Ku"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01875"
SQ SEQUENCE 261 AA; 29440 MW; AA81ACD962E27766 CRC64;
MAVQGIWSGT ISFSLVAIPV QLVKAVAIGR VSFRLLHDKD YSPLARRMFC PEQEKMVPPD
EIIRGYEIGP DRYLPITDEE LESVSPERSR TIEIVEFIDM NEVDPIYYDH PYYLVPLKGG
EKAYRLLVEV MRRTNKAGLA KFVLAEREYL VAVKSTEGAL TLITLHYSDE VLSDEDIAPK
EGKIAAEVKS GIKKSIKNMM ADFNPGKYAD ERRDKVMDLL KKKVKEKAPV AAPEVEKAEG
EGPADLIAAL EEIMREVKKN R