KU1_SACEN
ID KU1_SACEN Reviewed; 324 AA.
AC A4FFJ9;
DT 24-NOV-2009, integrated into UniProtKB/Swiss-Prot.
DT 17-APR-2007, sequence version 1.
DT 25-MAY-2022, entry version 82.
DE RecName: Full=Non-homologous end joining protein Ku 1 {ECO:0000255|HAMAP-Rule:MF_01875};
GN Name=ku1 {ECO:0000255|HAMAP-Rule:MF_01875}; OrderedLocusNames=SACE_3550;
OS Saccharopolyspora erythraea (strain ATCC 11635 / DSM 40517 / JCM 4748 /
OS NBRC 13426 / NCIMB 8594 / NRRL 2338).
OC Bacteria; Actinobacteria; Pseudonocardiales; Pseudonocardiaceae;
OC Saccharopolyspora.
OX NCBI_TaxID=405948;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 11635 / DSM 40517 / JCM 4748 / NBRC 13426 / NCIMB 8594 / NRRL
RC 2338;
RX PubMed=17369815; DOI=10.1038/nbt1297;
RA Oliynyk M., Samborskyy M., Lester J.B., Mironenko T., Scott N., Dickens S.,
RA Haydock S.F., Leadlay P.F.;
RT "Complete genome sequence of the erythromycin-producing bacterium
RT Saccharopolyspora erythraea NRRL23338.";
RL Nat. Biotechnol. 25:447-453(2007).
CC -!- FUNCTION: With LigD forms a non-homologous end joining (NHEJ) DNA
CC repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds
CC linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA
CC nor ssDNA. Recruits and stimulates the ligase activity of LigD.
CC {ECO:0000255|HAMAP-Rule:MF_01875}.
CC -!- SUBUNIT: Homodimer. Interacts with LigD. {ECO:0000255|HAMAP-
CC Rule:MF_01875}.
CC -!- SIMILARITY: Belongs to the prokaryotic Ku family. {ECO:0000255|HAMAP-
CC Rule:MF_01875}.
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DR EMBL; AM420293; CAM02824.1; -; Genomic_DNA.
DR RefSeq; WP_009942150.1; NZ_PDBV01000001.1.
DR AlphaFoldDB; A4FFJ9; -.
DR SMR; A4FFJ9; -.
DR STRING; 405948.SACE_3550; -.
DR EnsemblBacteria; CAM02824; CAM02824; SACE_3550.
DR KEGG; sen:SACE_3550; -.
DR eggNOG; COG1273; Bacteria.
DR HOGENOM; CLU_048975_1_1_11; -.
DR OMA; QVKGYPR; -.
DR OrthoDB; 1724780at2; -.
DR Proteomes; UP000006728; Chromosome.
DR GO; GO:0003690; F:double-stranded DNA binding; IEA:UniProtKB-UniRule.
DR GO; GO:0006310; P:DNA recombination; IEA:UniProtKB-KW.
DR GO; GO:0006353; P:DNA-templated transcription, termination; IEA:InterPro.
DR GO; GO:0006303; P:double-strand break repair via nonhomologous end joining; IEA:UniProtKB-UniRule.
DR CDD; cd00789; KU_like; 1.
DR Gene3D; 2.40.290.10; -; 1.
DR HAMAP; MF_01875; Prokaryotic_Ku; 1.
DR InterPro; IPR006164; Ku70/Ku80_beta-barrel_dom.
DR InterPro; IPR009187; Prok_Ku.
DR InterPro; IPR011112; Rho_N.
DR InterPro; IPR016194; SPOC-like_C_dom_sf.
DR PANTHER; PTHR41251; PTHR41251; 1.
DR Pfam; PF02735; Ku; 1.
DR PIRSF; PIRSF006493; Prok_Ku; 1.
DR SMART; SM00559; Ku78; 1.
DR SMART; SM00959; Rho_N; 1.
DR SUPFAM; SSF100939; SSF100939; 1.
DR TIGRFAMs; TIGR02772; Ku_bact; 1.
PE 3: Inferred from homology;
KW DNA damage; DNA recombination; DNA repair; DNA-binding; Reference proteome.
FT CHAIN 1..324
FT /note="Non-homologous end joining protein Ku 1"
FT /id="PRO_0000389196"
FT DOMAIN 10..193
FT /note="Ku"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01875"
FT REGION 256..324
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 256..304
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 324 AA; 36239 MW; 01479415CFF7CE0D CRC64;
MPRKIWTGSI NFGLVTIPVG LYAATEDHSI QFHQYERGTT DRVRMKRVNE RTGDEVGYND
IVKGREVGGV LVAVEPSELD EIAPKLSRTI DINTFVDLNA IDPVYFQKTY WLAPGSKEHF
RPYNLLRRAM DETNQVGIAT FVMRGREYLT AVRAEDSVLA LNTMFFADEI RDPGELVGDA
SSVAKPSDKE IQMATMIIES MSGDWEPEQY EDTYTARVEK LLEDKAEGRA PEVEEAPAEP
SDVIDLTEAL RRSVDQARRG RGGQVPRQRD EEQDVSALSK AELDKKAKEL GIKGRSKMKR
ADLEAAVAES QGSASGGRRR RRAS
