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ARCA_RHIET
ID   ARCA_RHIET              Reviewed;         409 AA.
AC   O31017;
DT   01-DEC-2000, integrated into UniProtKB/Swiss-Prot.
DT   01-JAN-1998, sequence version 1.
DT   03-AUG-2022, entry version 87.
DE   RecName: Full=Arginine deiminase;
DE            Short=ADI;
DE            EC=3.5.3.6;
DE   AltName: Full=Arginine dihydrolase;
DE            Short=AD;
GN   Name=arcA;
OS   Rhizobium etli.
OC   Bacteria; Proteobacteria; Alphaproteobacteria; Hyphomicrobiales;
OC   Rhizobiaceae; Rhizobium/Agrobacterium group; Rhizobium.
OX   NCBI_TaxID=29449;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   PubMed=9393705; DOI=10.1128/jb.179.23.7403-7409.1997;
RA   D'Hooghe I., Vander Wauwe C., Michiels J., Tricot C., de Wilde P.,
RA   Vanderleyden J., Stalon V.;
RT   "The arginine deiminase pathway in Rhizobium etli: DNA sequence analysis
RT   and functional study of the arcABC genes.";
RL   J. Bacteriol. 179:7403-7409(1997).
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=H2O + L-arginine = L-citrulline + NH4(+);
CC         Xref=Rhea:RHEA:19597, ChEBI:CHEBI:15377, ChEBI:CHEBI:28938,
CC         ChEBI:CHEBI:32682, ChEBI:CHEBI:57743; EC=3.5.3.6;
CC   -!- PATHWAY: Amino-acid degradation; L-arginine degradation via ADI
CC       pathway; carbamoyl phosphate from L-arginine: step 1/2.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the arginine deiminase family. {ECO:0000305}.
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DR   EMBL; AF025543; AAC46018.1; -; Genomic_DNA.
DR   AlphaFoldDB; O31017; -.
DR   SMR; O31017; -.
DR   STRING; 491916.RHECIAT_CH0000128; -.
DR   UniPathway; UPA00254; UER00364.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0016990; F:arginine deiminase activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0019547; P:arginine catabolic process to ornithine; IEA:UniProtKB-UniPathway.
DR   GO; GO:0018101; P:protein citrullination; IEA:GOC.
DR   HAMAP; MF_00242; Arg_deiminase; 1.
DR   InterPro; IPR003876; Arg_deiminase.
DR   PIRSF; PIRSF006356; Arg_deiminase; 1.
DR   PRINTS; PR01466; ARGDEIMINASE.
DR   TIGRFAMs; TIGR01078; arcA; 1.
PE   3: Inferred from homology;
KW   Arginine metabolism; Cytoplasm; Hydrolase.
FT   CHAIN           1..409
FT                   /note="Arginine deiminase"
FT                   /id="PRO_0000182228"
FT   ACT_SITE        398
FT                   /note="Amidino-cysteine intermediate"
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   409 AA;  45656 MW;  84CFCE0B936E8383 CRC64;
     MRGFGVHSEV GKLRTVMVCR PSLAHQRLTP ANCHDLLFDD VLWVHEAQKD HFDFVLKMQE
     RGVEVLELHD LLGQTLANQQ ARDFLLDRRI TPNVLGSQIA EAMRPWLDEM PAAQLAAFMI
     GGIAISDLPE VKAKSLMLSA LPETDFVIPP IPNTLFQRDP SCWIYGGVTC NPMFWPARRA
     ETLIQRAIYK FHPIFLGGDF QIWWGDSDQP FANASMEGGD VMPIGNGTVL IGMGERTTYQ
     AVGQVAQALF RSKAAKRVVG CLMPKSRAAM HLDTVFSFCD RDVVTLFAEV VDQVRCYSMY
     PKDDDGTFEI HPDNRPMLDV VAEALDLPQL RTVETGGNSY QAEREQWDDG NNVVALEPGV
     VVAYDRNTYT NTLLRKAGIE VITIRGSELG RGRGGGHCMT CPIWRDPAY
 
 
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