ID   KU2_GEOUR               Reviewed;         256 AA.
AC   A5G743;
DT   24-NOV-2009, integrated into UniProtKB/Swiss-Prot.
DT   12-JUN-2007, sequence version 1.
DT   25-MAY-2022, entry version 82.
DE   RecName: Full=Non-homologous end joining protein Ku 2 {ECO:0000255|HAMAP-Rule:MF_01875};
GN   Name=ku2 {ECO:0000255|HAMAP-Rule:MF_01875}; OrderedLocusNames=Gura_3455;
OS   Geotalea uraniireducens (strain Rf4) (Geobacter uraniireducens).
OC   Bacteria; Proteobacteria; Deltaproteobacteria; Desulfuromonadales;
OC   Geobacteraceae; Geotalea.
OX   NCBI_TaxID=351605;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC BAA-1134 / JCM 13001 / Rf4;
RG   US DOE Joint Genome Institute;
RA   Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C.,
RA   Glavina del Rio T., Hammon N., Israni S., Dalin E., Tice H., Pitluck S.,
RA   Chertkov O., Brettin T., Bruce D., Han C., Schmutz J., Larimer F., Land M.,
RA   Hauser L., Kyrpides N., Mikhailova N., Shelobolina E., Aklujkar M.,
RA   Lovley D., Richardson P.;
RT   "Complete sequence of Geobacter uraniireducens Rf4.";
RL   Submitted (MAY-2007) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: With LigD forms a non-homologous end joining (NHEJ) DNA
CC       repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds
CC       linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA
CC       nor ssDNA. Recruits and stimulates the ligase activity of LigD.
CC       {ECO:0000255|HAMAP-Rule:MF_01875}.
CC   -!- SUBUNIT: Homodimer. Interacts with LigD. {ECO:0000255|HAMAP-
CC       Rule:MF_01875}.
CC   -!- SIMILARITY: Belongs to the prokaryotic Ku family. {ECO:0000255|HAMAP-
CC       Rule:MF_01875}.
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DR   EMBL; CP000698; ABQ27611.1; -; Genomic_DNA.
DR   RefSeq; WP_011940272.1; NC_009483.1.
DR   AlphaFoldDB; A5G743; -.
DR   STRING; 351605.Gura_3455; -.
DR   EnsemblBacteria; ABQ27611; ABQ27611; Gura_3455.
DR   KEGG; gur:Gura_3455; -.
DR   HOGENOM; CLU_048975_0_1_7; -.
DR   OMA; WKGYLRL; -.
DR   OrthoDB; 1724780at2; -.
DR   Proteomes; UP000006695; Chromosome.
DR   GO; GO:0003690; F:double-stranded DNA binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0006310; P:DNA recombination; IEA:UniProtKB-KW.
DR   GO; GO:0006303; P:double-strand break repair via nonhomologous end joining; IEA:UniProtKB-UniRule.
DR   CDD; cd00789; KU_like; 1.
DR   Gene3D; 2.40.290.10; -; 1.
DR   HAMAP; MF_01875; Prokaryotic_Ku; 1.
DR   InterPro; IPR006164; Ku70/Ku80_beta-barrel_dom.
DR   InterPro; IPR009187; Prok_Ku.
DR   InterPro; IPR016194; SPOC-like_C_dom_sf.
DR   PANTHER; PTHR41251; PTHR41251; 1.
DR   Pfam; PF02735; Ku; 1.
DR   PIRSF; PIRSF006493; Prok_Ku; 1.
DR   SMART; SM00559; Ku78; 1.
DR   SUPFAM; SSF100939; SSF100939; 1.
DR   TIGRFAMs; TIGR02772; Ku_bact; 1.
PE   3: Inferred from homology;
KW   DNA damage; DNA recombination; DNA repair; DNA-binding; Reference proteome.
FT   CHAIN           1..256
FT                   /note="Non-homologous end joining protein Ku 2"
FT                   /id="PRO_0000389186"
FT   DOMAIN          13..184
FT                   /note="Ku"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01875"
SQ   SEQUENCE   256 AA;  29117 MW;  ED6B79C660C158CD CRC64;
     MAGGTIWKGY IHFADTDVAV KLHAAVKAER IQFHLLHKRD HVKLHQQMIC AYEKIPVPTE
     AQTKGFEVEE GKYIIVDPDE LEQTAPESSR MIEVHEFVKT GQIDPIFLDR VYYLEPDLHS
     EGYSELVGAL QEMGAEGICT WTMRNRSYLG ALQASGKILR LNTLRYADEV ISVKSLELQE
     SPVSEKELKI GSDLINQLTT PFQPQKFENE HEKKLQKLIE KKARGEKIAL LRPRLLKPTA
     SDKLLQALEE SLKKVA