ID   KU3_SACEN               Reviewed;         263 AA.
AC   A4FQ42;
DT   24-NOV-2009, integrated into UniProtKB/Swiss-Prot.
DT   24-NOV-2009, sequence version 2.
DT   25-MAY-2022, entry version 67.
DE   RecName: Full=Non-homologous end joining protein Ku 3 {ECO:0000255|HAMAP-Rule:MF_01875};
GN   Name=ku3 {ECO:0000255|HAMAP-Rule:MF_01875}; OrderedLocusNames=SACE_7006;
OS   Saccharopolyspora erythraea (strain ATCC 11635 / DSM 40517 / JCM 4748 /
OS   NBRC 13426 / NCIMB 8594 / NRRL 2338).
OC   Bacteria; Actinobacteria; Pseudonocardiales; Pseudonocardiaceae;
OC   Saccharopolyspora.
OX   NCBI_TaxID=405948;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 11635 / DSM 40517 / JCM 4748 / NBRC 13426 / NCIMB 8594 / NRRL
RC   2338;
RX   PubMed=17369815; DOI=10.1038/nbt1297;
RA   Oliynyk M., Samborskyy M., Lester J.B., Mironenko T., Scott N., Dickens S.,
RA   Haydock S.F., Leadlay P.F.;
RT   "Complete genome sequence of the erythromycin-producing bacterium
RT   Saccharopolyspora erythraea NRRL23338.";
RL   Nat. Biotechnol. 25:447-453(2007).
CC   -!- FUNCTION: With LigD forms a non-homologous end joining (NHEJ) DNA
CC       repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds
CC       linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA
CC       nor ssDNA. Recruits and stimulates the ligase activity of LigD.
CC       {ECO:0000255|HAMAP-Rule:MF_01875}.
CC   -!- SUBUNIT: Homodimer. Interacts with LigD. {ECO:0000255|HAMAP-
CC       Rule:MF_01875}.
CC   -!- SIMILARITY: Belongs to the prokaryotic Ku family. {ECO:0000255|HAMAP-
CC       Rule:MF_01875}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=CAM06167.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000305};
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DR   EMBL; AM420293; CAM06167.1; ALT_INIT; Genomic_DNA.
DR   AlphaFoldDB; A4FQ42; -.
DR   SMR; A4FQ42; -.
DR   STRING; 405948.SACE_7006; -.
DR   EnsemblBacteria; CAM06167; CAM06167; SACE_7006.
DR   KEGG; sen:SACE_7006; -.
DR   eggNOG; COG1273; Bacteria.
DR   HOGENOM; CLU_048975_0_1_11; -.
DR   Proteomes; UP000006728; Chromosome.
DR   GO; GO:0003690; F:double-stranded DNA binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0006310; P:DNA recombination; IEA:UniProtKB-KW.
DR   GO; GO:0006303; P:double-strand break repair via nonhomologous end joining; IEA:UniProtKB-UniRule.
DR   CDD; cd00789; KU_like; 1.
DR   Gene3D; 2.40.290.10; -; 1.
DR   HAMAP; MF_01875; Prokaryotic_Ku; 1.
DR   InterPro; IPR006164; Ku70/Ku80_beta-barrel_dom.
DR   InterPro; IPR009187; Prok_Ku.
DR   InterPro; IPR016194; SPOC-like_C_dom_sf.
DR   PANTHER; PTHR41251; PTHR41251; 1.
DR   Pfam; PF02735; Ku; 1.
DR   PIRSF; PIRSF006493; Prok_Ku; 1.
DR   SMART; SM00559; Ku78; 1.
DR   SUPFAM; SSF100939; SSF100939; 1.
DR   TIGRFAMs; TIGR02772; Ku_bact; 1.
PE   3: Inferred from homology;
KW   DNA damage; DNA recombination; DNA repair; DNA-binding; Reference proteome.
FT   CHAIN           1..263
FT                   /note="Non-homologous end joining protein Ku 3"
FT                   /id="PRO_0000389197"
FT   DOMAIN          6..169
FT                   /note="Ku"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01875"
SQ   SEQUENCE   263 AA;  29616 MW;  748C770510774EE9 CRC64;
     MECCRFGLVS VPVQLFTAVE RHTIRFHQVQ RGTGDRVRQK RVNERTGQEV PFEEVVKGYP
     TEDGWVIVDP KELEDIAPGR SRTLEIVGFV DLDEIAPVYF RDTYYLAPSG PQYTKVYGLL
     REALATANRA GIATFVMRNR QYLAALKAEH EVLAVYLLHW ADEVRDPHRE LGASLPDHSG
     ASEQELRMAV QLIEAMAIDW DPADYHDTYQ QQVQALIDAK RAGGTLEPGI PPPRETEAVD
     LMQALRASVE HARAGRSGDR DTH