ID   KUP1_CUPNH              Reviewed;         632 AA.
AC   Q0KBR7;
DT   06-MAR-2007, integrated into UniProtKB/Swiss-Prot.
DT   03-OCT-2006, sequence version 1.
DT   25-MAY-2022, entry version 83.
DE   RecName: Full=Probable potassium transport system protein kup 1 {ECO:0000255|HAMAP-Rule:MF_01522};
GN   Name=kup1 {ECO:0000255|HAMAP-Rule:MF_01522}; OrderedLocusNames=H16_A1419;
OS   Cupriavidus necator (strain ATCC 17699 / DSM 428 / KCTC 22496 / NCIMB 10442
OS   / H16 / Stanier 337) (Ralstonia eutropha).
OC   Bacteria; Proteobacteria; Betaproteobacteria; Burkholderiales;
OC   Burkholderiaceae; Cupriavidus.
OX   NCBI_TaxID=381666;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 17699 / DSM 428 / KCTC 22496 / NCIMB 10442 / H16 / Stanier 337;
RX   PubMed=16964242; DOI=10.1038/nbt1244;
RA   Pohlmann A., Fricke W.F., Reinecke F., Kusian B., Liesegang H., Cramm R.,
RA   Eitinger T., Ewering C., Poetter M., Schwartz E., Strittmatter A., Voss I.,
RA   Gottschalk G., Steinbuechel A., Friedrich B., Bowien B.;
RT   "Genome sequence of the bioplastic-producing 'Knallgas' bacterium Ralstonia
RT   eutropha H16.";
RL   Nat. Biotechnol. 24:1257-1262(2006).
CC   -!- FUNCTION: Transport of potassium into the cell. {ECO:0000255|HAMAP-
CC       Rule:MF_01522}.
CC   -!- SUBCELLULAR LOCATION: Cell inner membrane {ECO:0000255|HAMAP-
CC       Rule:MF_01522}; Multi-pass membrane protein {ECO:0000255|HAMAP-
CC       Rule:MF_01522}.
CC   -!- SIMILARITY: Belongs to the HAK/KUP transporter (TC 2.A.72) family.
CC       {ECO:0000255|HAMAP-Rule:MF_01522}.
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DR   EMBL; AM260479; CAJ92554.1; -; Genomic_DNA.
DR   RefSeq; WP_011615071.1; NZ_CP039287.1.
DR   AlphaFoldDB; Q0KBR7; -.
DR   STRING; 381666.H16_A1419; -.
DR   PRIDE; Q0KBR7; -.
DR   EnsemblBacteria; CAJ92554; CAJ92554; H16_A1419.
DR   GeneID; 57643518; -.
DR   KEGG; reh:H16_A1419; -.
DR   PATRIC; fig|381666.6.peg.1807; -.
DR   eggNOG; COG3158; Bacteria.
DR   HOGENOM; CLU_008142_4_2_4; -.
DR   OMA; AIRVSWL; -.
DR   OrthoDB; 589903at2; -.
DR   Proteomes; UP000008210; Chromosome 1.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0015079; F:potassium ion transmembrane transporter activity; IEA:UniProtKB-UniRule.
DR   HAMAP; MF_01522; Kup; 1.
DR   InterPro; IPR003855; K+_transporter.
DR   InterPro; IPR023051; K+_uptake_low_affin.
DR   PANTHER; PTHR30540; PTHR30540; 1.
DR   Pfam; PF02705; K_trans; 1.
PE   3: Inferred from homology;
KW   Cell inner membrane; Cell membrane; Ion transport; Membrane; Potassium;
KW   Potassium transport; Reference proteome; Transmembrane;
KW   Transmembrane helix; Transport.
FT   CHAIN           1..632
FT                   /note="Probable potassium transport system protein kup 1"
FT                   /id="PRO_0000279814"
FT   TRANSMEM        19..39
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01522"
FT   TRANSMEM        59..79
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01522"
FT   TRANSMEM        110..130
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01522"
FT   TRANSMEM        146..166
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01522"
FT   TRANSMEM        178..198
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01522"
FT   TRANSMEM        213..233
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01522"
FT   TRANSMEM        256..276
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01522"
FT   TRANSMEM        298..318
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01522"
FT   TRANSMEM        346..366
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01522"
FT   TRANSMEM        373..393
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01522"
FT   TRANSMEM        403..423
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01522"
FT   TRANSMEM        428..448
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01522"
SQ   SEQUENCE   632 AA;  69085 MW;  960774EBB8C7A963 CRC64;
     MTQSTTSHYF VESPSTRALV LGAVGVVFGD IGTSPLYALK ECFSKEHGIM FSPEAVLGVI
     SMLFWAMIIV VSIKYVVFVM RADNDGEGGV LALMALVLRT VAPRSGRARV LMMLGIFGAC
     MFYGDAVITP AISVLSAVEG LEIAAPQLSQ FVIPITLMIL AALFLIQRHG TATMGKLFGP
     IMTAWFLALG GLGILHLVQA PEILKAINPY YAITFLVEHA LQAFIVLGSV FLVLTGAEAL
     YVDMGHFGAR PIRIGWFVLV MPCLMLNYFG QGAMLLHNPA GAENPFYLMV PDLLQIPMVL
     LATCATVIAS QAVISGAFSL TSQAIQLGFL PRMRVRYTSA AEIGQIYLPV INWLLLVLVI
     GVVISFKKSE NLAAAYGIAV TTTMVITTIL AAVCMRSVWK WNPALVAVVG LAFIVVDLSF
     FAANLLKVAE GGWFPLLLGS AAFFLLMTWY SGRKLLRARS LEDGIPLEPF IAGLLAHPPH
     RVEGTAVFLT GNTESVPVSL LHNLKHNRVL HERVVFLTFV TRDIPYVDDD HRLSCKDVGG
     GVFILKSEYG FKETPDVQRV LDLADRKLGM HFELMETSFF IARESVIPSK LPGMPMWRES
     LFAWMHQNGA KPSDFFQIPA NRVVELGTKV EI