ID   KUP1_LACAC              Reviewed;         650 AA.
AC   Q5FMK7;
DT   12-APR-2005, integrated into UniProtKB/Swiss-Prot.
DT   12-APR-2005, sequence version 2.
DT   03-AUG-2022, entry version 89.
DE   RecName: Full=Probable potassium transport system protein kup 1 {ECO:0000255|HAMAP-Rule:MF_01522};
GN   Name=kup1 {ECO:0000255|HAMAP-Rule:MF_01522}; OrderedLocusNames=LBA0166;
OS   Lactobacillus acidophilus (strain ATCC 700396 / NCK56 / N2 / NCFM).
OC   Bacteria; Firmicutes; Bacilli; Lactobacillales; Lactobacillaceae;
OC   Lactobacillus.
OX   NCBI_TaxID=272621;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 700396 / NCK56 / N2 / NCFM;
RX   PubMed=15671160; DOI=10.1073/pnas.0409188102;
RA   Altermann E., Russell W.M., Azcarate-Peril M.A., Barrangou R., Buck B.L.,
RA   McAuliffe O., Souther N., Dobson A., Duong T., Callanan M., Lick S.,
RA   Hamrick A., Cano R., Klaenhammer T.R.;
RT   "Complete genome sequence of the probiotic lactic acid bacterium
RT   Lactobacillus acidophilus NCFM.";
RL   Proc. Natl. Acad. Sci. U.S.A. 102:3906-3912(2005).
CC   -!- FUNCTION: Transport of potassium into the cell. {ECO:0000255|HAMAP-
CC       Rule:MF_01522}.
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000255|HAMAP-Rule:MF_01522};
CC       Multi-pass membrane protein {ECO:0000255|HAMAP-Rule:MF_01522}.
CC   -!- SIMILARITY: Belongs to the HAK/KUP transporter (TC 2.A.72) family.
CC       {ECO:0000255|HAMAP-Rule:MF_01522}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=AAV42067.1; Type=Frameshift; Evidence={ECO:0000305};
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DR   EMBL; CP000033; AAV42067.1; ALT_FRAME; Genomic_DNA.
DR   RefSeq; YP_193098.1; NC_006814.3.
DR   AlphaFoldDB; Q5FMK7; -.
DR   PRIDE; Q5FMK7; -.
DR   EnsemblBacteria; AAV42067; AAV42067; LBA0166.
DR   KEGG; lac:LBA0166; -.
DR   PATRIC; fig|272621.13.peg.161; -.
DR   eggNOG; COG3158; Bacteria.
DR   HOGENOM; CLU_008142_4_1_9; -.
DR   Proteomes; UP000006381; Chromosome.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0015079; F:potassium ion transmembrane transporter activity; IEA:UniProtKB-UniRule.
DR   HAMAP; MF_01522; Kup; 1.
DR   InterPro; IPR003855; K+_transporter.
DR   InterPro; IPR023051; K+_uptake_low_affin.
DR   PANTHER; PTHR30540; PTHR30540; 2.
DR   Pfam; PF02705; K_trans; 1.
PE   3: Inferred from homology;
KW   Cell membrane; Ion transport; Membrane; Potassium; Potassium transport;
KW   Reference proteome; Transmembrane; Transmembrane helix; Transport.
FT   CHAIN           1..650
FT                   /note="Probable potassium transport system protein kup 1"
FT                   /id="PRO_0000209020"
FT   TRANSMEM        12..32
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01522"
FT   TRANSMEM        54..74
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01522"
FT   TRANSMEM        97..117
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01522"
FT   TRANSMEM        139..159
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01522"
FT   TRANSMEM        170..190
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01522"
FT   TRANSMEM        216..236
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01522"
FT   TRANSMEM        249..269
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01522"
FT   TRANSMEM        295..315
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01522"
FT   TRANSMEM        344..364
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01522"
FT   TRANSMEM        375..395
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01522"
FT   TRANSMEM        400..420
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01522"
FT   TRANSMEM        428..448
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01522"
SQ   SEQUENCE   650 AA;  71818 MW;  C6B02F1943967454 CRC64;
     MNNKSKRMSA AGLLIAIGIV YGDIGTSPLY VMKSIVKAMG GIGNVNREFI IGSISLVLWT
     VTLLTTLQTV IIALKATNHG EGGIFALYTL VRKRAKWLVL PALIGGAAIL ADGTLTPAVT
     VTTAIEGLKG LQLGGGVPVS SQSMVIAITV LILLVLFSIQ KMGTSIIGKA FGPIMFVWFT
     FLGVIGLINM SGDWSILQAI NPVYAIKLLF SPYNKAGIFI LGSIFLATTG AEALYSDVGH
     VGKKNIIGSW PFVFVCLSLN YFGQGVWILN NPTYRPADGG VLNPFYEMIP SDFRLAAIIL
     ATIAAVIASQ ALITGSFTLV AEASGLKFLP RMKIDYPSTE KGQIYIPSIN KGICVATIAI
     VLYFQTSAHM EAAYGLSITI SMLMTTILLY EWLAMKKVNP VWNWIFLIFF GVLDIMFMIS
     SLTKFTHGGY VSLFIAGAIG FIMYVWYYGN KIRDKREARN AYVRLDEYTD MLTNLSHDEN
     YPTYATNLVY MANVKYNKFI KREILYSILD KRPKRAKAYW FVTVNVTNEP FTAEYAVNTY
     GTKNVINIQL YLGFKKQTSV NVYIRQIVHD LIADGTIEPQ PQEYTTTPGR DVGDFSFVIV
     NDVISPQTQL IGYEKWLVEA RVRLQNLSSN PASWFGLEYA DTVIERVPLS