ID   KUP1_LACJO              Reviewed;         683 AA.
AC   Q74LN3;
DT   27-SEP-2004, integrated into UniProtKB/Swiss-Prot.
DT   05-JUL-2004, sequence version 1.
DT   25-MAY-2022, entry version 106.
DE   RecName: Full=Probable potassium transport system protein kup 1 {ECO:0000255|HAMAP-Rule:MF_01522};
GN   Name=kup1 {ECO:0000255|HAMAP-Rule:MF_01522}; OrderedLocusNames=LJ_0150;
OS   Lactobacillus johnsonii (strain CNCM I-12250 / La1 / NCC 533).
OC   Bacteria; Firmicutes; Bacilli; Lactobacillales; Lactobacillaceae;
OC   Lactobacillus.
OX   NCBI_TaxID=257314;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=CNCM I-1225 / La1 / NCC 533;
RX   PubMed=14983040; DOI=10.1073/pnas.0307327101;
RA   Pridmore R.D., Berger B., Desiere F., Vilanova D., Barretto C.,
RA   Pittet A.-C., Zwahlen M.-C., Rouvet M., Altermann E., Barrangou R.,
RA   Mollet B., Mercenier A., Klaenhammer T., Arigoni F., Schell M.A.;
RT   "The genome sequence of the probiotic intestinal bacterium Lactobacillus
RT   johnsonii NCC 533.";
RL   Proc. Natl. Acad. Sci. U.S.A. 101:2512-2517(2004).
CC   -!- FUNCTION: Transport of potassium into the cell. {ECO:0000255|HAMAP-
CC       Rule:MF_01522}.
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000255|HAMAP-Rule:MF_01522};
CC       Multi-pass membrane protein {ECO:0000255|HAMAP-Rule:MF_01522}.
CC   -!- SIMILARITY: Belongs to the HAK/KUP transporter (TC 2.A.72) family.
CC       {ECO:0000255|HAMAP-Rule:MF_01522}.
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DR   EMBL; AE017198; AAS08132.1; -; Genomic_DNA.
DR   RefSeq; WP_011161368.1; NC_005362.1.
DR   AlphaFoldDB; Q74LN3; -.
DR   STRING; 257314.LJ_0150; -.
DR   EnsemblBacteria; AAS08132; AAS08132; LJ_0150.
DR   KEGG; ljo:LJ_0150; -.
DR   PATRIC; fig|257314.6.peg.160; -.
DR   eggNOG; COG3158; Bacteria.
DR   HOGENOM; CLU_008142_4_1_9; -.
DR   OMA; TILLYEW; -.
DR   Proteomes; UP000000581; Chromosome.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0015079; F:potassium ion transmembrane transporter activity; IEA:UniProtKB-UniRule.
DR   HAMAP; MF_01522; Kup; 1.
DR   InterPro; IPR003855; K+_transporter.
DR   InterPro; IPR023051; K+_uptake_low_affin.
DR   PANTHER; PTHR30540; PTHR30540; 2.
DR   Pfam; PF02705; K_trans; 1.
PE   3: Inferred from homology;
KW   Cell membrane; Ion transport; Membrane; Potassium; Potassium transport;
KW   Reference proteome; Transmembrane; Transmembrane helix; Transport.
FT   CHAIN           1..683
FT                   /note="Probable potassium transport system protein kup 1"
FT                   /id="PRO_0000209022"
FT   TRANSMEM        13..33
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01522"
FT   TRANSMEM        55..75
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01522"
FT   TRANSMEM        98..118
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01522"
FT   TRANSMEM        139..159
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01522"
FT   TRANSMEM        168..188
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01522"
FT   TRANSMEM        218..238
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01522"
FT   TRANSMEM        251..271
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01522"
FT   TRANSMEM        296..316
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01522"
FT   TRANSMEM        345..365
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01522"
FT   TRANSMEM        376..396
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01522"
FT   TRANSMEM        401..421
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01522"
FT   TRANSMEM        426..446
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01522"
SQ   SEQUENCE   683 AA;  75883 MW;  2CD0AD18F7B6E228 CRC64;
     MNEKTRKNIS AAGLLIAIGI VYGDIGTSPL YVMKSIVAGN GGIANVNRDF IVGSISLVLW
     TVTLLTTLQT VFIALKATNH GEGGIFALYT LVRKRAKWLV LPALIGGAAI LADGTLTPAV
     TVTTAIEGLK GIEFGHGNVP VSTQGTVIAI TVVILLLLFS IQRMGTSIIG KAFGPIMFIW
     FTFLGVIGLM NMMGDLSILQ ALNPYYAIKL LFSPYNKAGI FILGSIFLAT TGAEALYSDV
     GHVGKGNIIG SWPYVFVCLS LNYFGQGVWI LNNPNYNAGN GDFNPFFEII PQNIRLAAIV
     LATIAAVIAS QALITGSFTL VAEASGLKFL PRMNIMYPST KKGQIYIPSV NKMICAATIA
     IVLFFQTSAH MEAAYGLSIT ISMLMTTILL YEWLAMKGVH TIWNWLFLIF FGFLDVMFML
     ASLSKFMHGG YVSLVIAGFI GIIMYVWYYG NKIRDKRESR NAYVRLDEYV DMLTNLSHDE
     DYPTFATNLV YMAKVKYNKF IKREILYSIL DKRPKRARAY WFVTVNVTNE PFTAEYAVNT
     YGTKNVINVQ LFLGFKQQTS VNVYLRQIVH DLIADGTIES QPQEYTTTPG RDVGDFSFVI
     VNDVISPQTQ LRSYEKFLVE ARVWLQNLSS NPASWFGLDY ADTVIERVPL ILGNQRRQHI
     TRIPPKKFED IKKKLQAEGE LKE