ID   KUP1_LACLA              Reviewed;         670 AA.
AC   Q9CHU5;
DT   27-SEP-2004, integrated into UniProtKB/Swiss-Prot.
DT   01-JUN-2001, sequence version 1.
DT   25-MAY-2022, entry version 95.
DE   RecName: Full=Probable potassium transport system protein kup 1 {ECO:0000255|HAMAP-Rule:MF_01522};
GN   Name=kup1 {ECO:0000255|HAMAP-Rule:MF_01522}; Synonyms=kupA;
GN   OrderedLocusNames=LL0623; ORFNames=L9458;
OS   Lactococcus lactis subsp. lactis (strain IL1403) (Streptococcus lactis).
OC   Bacteria; Firmicutes; Bacilli; Lactobacillales; Streptococcaceae;
OC   Lactococcus.
OX   NCBI_TaxID=272623;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=IL1403;
RX   PubMed=11337471; DOI=10.1101/gr.gr-1697r;
RA   Bolotin A., Wincker P., Mauger S., Jaillon O., Malarme K., Weissenbach J.,
RA   Ehrlich S.D., Sorokin A.;
RT   "The complete genome sequence of the lactic acid bacterium Lactococcus
RT   lactis ssp. lactis IL1403.";
RL   Genome Res. 11:731-753(2001).
CC   -!- FUNCTION: Transport of potassium into the cell. {ECO:0000255|HAMAP-
CC       Rule:MF_01522}.
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000255|HAMAP-Rule:MF_01522};
CC       Multi-pass membrane protein {ECO:0000255|HAMAP-Rule:MF_01522}.
CC   -!- SIMILARITY: Belongs to the HAK/KUP transporter (TC 2.A.72) family.
CC       {ECO:0000255|HAMAP-Rule:MF_01522}.
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DR   EMBL; AE005176; AAK04721.1; -; Genomic_DNA.
DR   PIR; G86702; G86702.
DR   RefSeq; NP_266779.1; NC_002662.1.
DR   RefSeq; WP_010905466.1; NC_002662.1.
DR   AlphaFoldDB; Q9CHU5; -.
DR   STRING; 272623.L9458; -.
DR   TCDB; 2.A.72.1.3; the k(+) uptake permease (kup) family.
DR   PaxDb; Q9CHU5; -.
DR   EnsemblBacteria; AAK04721; AAK04721; L9458.
DR   KEGG; lla:L9458; -.
DR   PATRIC; fig|272623.7.peg.665; -.
DR   eggNOG; COG3158; Bacteria.
DR   HOGENOM; CLU_008142_4_1_9; -.
DR   OMA; VKYICIA; -.
DR   Proteomes; UP000002196; Chromosome.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0015079; F:potassium ion transmembrane transporter activity; IEA:UniProtKB-UniRule.
DR   HAMAP; MF_01522; Kup; 1.
DR   InterPro; IPR003855; K+_transporter.
DR   InterPro; IPR023051; K+_uptake_low_affin.
DR   PANTHER; PTHR30540; PTHR30540; 1.
DR   Pfam; PF02705; K_trans; 1.
PE   3: Inferred from homology;
KW   Cell membrane; Ion transport; Membrane; Potassium; Potassium transport;
KW   Reference proteome; Transmembrane; Transmembrane helix; Transport.
FT   CHAIN           1..670
FT                   /note="Probable potassium transport system protein kup 1"
FT                   /id="PRO_0000209024"
FT   TRANSMEM        14..34
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01522"
FT   TRANSMEM        58..78
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01522"
FT   TRANSMEM        101..121
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01522"
FT   TRANSMEM        147..167
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01522"
FT   TRANSMEM        175..195
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01522"
FT   TRANSMEM        220..240
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01522"
FT   TRANSMEM        252..272
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01522"
FT   TRANSMEM        294..314
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01522"
FT   TRANSMEM        345..365
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01522"
FT   TRANSMEM        374..394
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01522"
FT   TRANSMEM        403..423
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01522"
FT   TRANSMEM        427..447
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01522"
SQ   SEQUENCE   670 AA;  74982 MW;  10E7A0DC8E801447 CRC64;
     MGYESNRSFN KATGAGFIIA MGIVYGDIGT SPLYTMESIV QGQGGLERIS ETSIIGALSL
     IIWTLTLITT VKYVWIALKA DNNHEGGIFS LFTLVRKYAK WLIIPAMIGG AALLSDGALT
     PAVTVTSAIE GLRSIPAFHE AFGQQQLPIV IITLAILAVL FLIQRFGTSI VGKVFGPVMF
     IWFSFLGITG LINLFGDFSV LQAINPYWAI HLLLSPENKA GIFVLGSVFL ATTGAEALYS
     DLGHVGRGNI HVSWPFVKVC IILSYCGQGA WLLQNRGKSL GDINPFFAVL PQNLIIFSVI
     LATLAAIIAS QALISGSFTL VSEAIRLKLL PRLRIFYPGE TFGQLYIPAV NLGLWLAASF
     IVVYFQSSAH MEAAYGLAIT VTMLMTTTLL TVYLSHYQKV KKVLVGLFFT VFIFIEGLFF
     AASAVKFMHG GYVVVIIAAM ILFVMAIWHK SDQLFYKYLN SSNLNDYKEQ MDKLRKDETY
     DLYHTNVVYL TAKMDKEWID RSILYSILDK RPKKAKVYWF VKVNVTDEPY TSEYEVDMLG
     TDFIVCVNLY LGFHMRQEIP RYLRTIVTNL MESGRLPQQN QTYSITPGRK VGDFRFIILE
     EKLINARQMP GFERFVLQTK EQIKKITASP ARWFGLHFSE VTVETVPLVL SDVKNLEIHE
     RISEENQGES