ID   KUP1_LACLM              Reviewed;         673 AA.
AC   P96790;
DT   27-SEP-2004, integrated into UniProtKB/Swiss-Prot.
DT   01-MAY-2007, sequence version 2.
DT   25-MAY-2022, entry version 76.
DE   RecName: Full=Putative potassium transport system protein kup 1;
GN   Name=kup1 {ECO:0000255|HAMAP-Rule:MF_01522}; Synonyms=kupA;
GN   OrderedLocusNames=llmg_0587;
OS   Lactococcus lactis subsp. cremoris (strain MG1363).
OC   Bacteria; Firmicutes; Bacilli; Lactobacillales; Streptococcaceae;
OC   Lactococcus; Lactococcus cremoris subsp. cremoris.
OX   NCBI_TaxID=416870;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=MG1363;
RX   PubMed=17307855; DOI=10.1128/jb.01768-06;
RA   Wegmann U., O'Connell-Motherway M., Zomer A., Buist G., Shearman C.,
RA   Canchaya C., Ventura M., Goesmann A., Gasson M.J., Kuipers O.P.,
RA   van Sinderen D., Kok J.;
RT   "The complete genome sequence of the lactic acid bacterial paradigm
RT   Lactococcus lactis subsp. cremoris MG1363.";
RL   J. Bacteriol. 189:3256-3270(2007).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-170.
RX   PubMed=9931298; DOI=10.1042/bj3380055;
RA   Tetaud E., Hanau S., Wells J.M., Le Page R.W.F., Adams M.J., Arkison S.,
RA   Barrett M.P.;
RT   "6-phosphogluconate dehydrogenase from Lactococcus lactis: a role for
RT   arginine residues in binding substrate and coenzyme.";
RL   Biochem. J. 338:55-60(1999).
CC   -!- FUNCTION: Transport of potassium into the cell. {ECO:0000255|HAMAP-
CC       Rule:MF_01522}.
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000255|HAMAP-Rule:MF_01522};
CC       Multi-pass membrane protein {ECO:0000255|HAMAP-Rule:MF_01522}.
CC   -!- SIMILARITY: Belongs to the HAK/KUP transporter (TC 2.A.72) family.
CC       {ECO:0000255|HAMAP-Rule:MF_01522}.
CC   -!- CAUTION: Could be the product of a pseudogene. {ECO:0000305}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=AM406671; Type=Erroneous termination; Note=Truncated C-terminus.; Evidence={ECO:0000305};
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DR   EMBL; AM406671; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; U74322; AAC12805.1; -; Genomic_DNA.
DR   AlphaFoldDB; P96790; -.
DR   Proteomes; UP000000364; Chromosome.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0015079; F:potassium ion transmembrane transporter activity; IEA:UniProtKB-UniRule.
DR   HAMAP; MF_01522; Kup; 1.
DR   InterPro; IPR003855; K+_transporter.
DR   InterPro; IPR023051; K+_uptake_low_affin.
DR   PANTHER; PTHR30540; PTHR30540; 1.
DR   Pfam; PF02705; K_trans; 1.
PE   5: Uncertain;
KW   Cell membrane; Ion transport; Membrane; Potassium; Potassium transport;
KW   Transmembrane; Transmembrane helix; Transport.
FT   CHAIN           1..673
FT                   /note="Putative potassium transport system protein kup 1"
FT                   /id="PRO_0000209026"
FT   TRANSMEM        14..34
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01522"
FT   TRANSMEM        58..78
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01522"
FT   TRANSMEM        101..121
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01522"
FT   TRANSMEM        147..167
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01522"
FT   TRANSMEM        175..195
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01522"
FT   TRANSMEM        220..240
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01522"
FT   TRANSMEM        252..272
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01522"
FT   TRANSMEM        294..314
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01522"
FT   TRANSMEM        345..365
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01522"
FT   TRANSMEM        374..394
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01522"
FT   TRANSMEM        403..423
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01522"
FT   TRANSMEM        427..447
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01522"
SQ   SEQUENCE   673 AA;  75343 MW;  9BDDF9F2C3E20536 CRC64;
     MGYQHNRSFN KATGAGFIIA MGIVYGDIGT SPLYTMESIV QGQGGLERIS ETSIIGALSL
     IIWTLTLITT VKYVWIALKA DNNHEGGVFS LFTLVRKYAK WLIIPAMIGG AALLSDGALT
     PAVTVTSAIE GLRSIPAFHE AFGQQQLPIV IITLAILAIL FLIQRFGTSI VGKVFGPVMF
     IWFSFLGITG LINLFGDFSV LQAINPYWAI HLLLSPENKA GIFVLGSVFL ATTGAEALYS
     DLGHVGRGNI HVSWPFVKVC IILSYCGQAA WLLQNRGKSL GDINPFFAVL PQSLIIFSVV
     LATLAAIIAS QALISGSFTL VSEAIRLKLL PRLKINYPGE TFGQLYIPAV NLGLWLAASF
     IVVYFQSSAH MEAAYGLAIT VTMLMTTILL TVYLAQHQKV KKVFVVLFFG AFIFIEGLFF
     AASAVKFLHG GYVVVILAAL ILFVMAIWHK SDQLFYKYLK SSNLNDYKEQ MNKLRKDESY
     DLYHTNVVYL TAKMDKEWID RSILYSILDK RPKKAEVYWF VKVNVTDEPY TSEYEVDMLG
     TDFIVCVNLY LGFHMRQEIP RYLRTIVTNL MESGRLPQQH QPYSIIPGRK VGDFRFILLE
     EKLINARQMP AFERFVLQTK EQIKKITASP ARWFGLHFSE VTVETVPLVL SDVRNLEIHE
     RISKENEVEN LSK