ID   KUP1_LACLS              Reviewed;         673 AA.
AC   Q031B2;
DT   06-MAR-2007, integrated into UniProtKB/Swiss-Prot.
DT   14-NOV-2006, sequence version 1.
DT   25-MAY-2022, entry version 77.
DE   RecName: Full=Probable potassium transport system protein kup 1 {ECO:0000255|HAMAP-Rule:MF_01522};
GN   Name=kup1 {ECO:0000255|HAMAP-Rule:MF_01522}; OrderedLocusNames=LACR_0643;
OS   Lactococcus lactis subsp. cremoris (strain SK11).
OC   Bacteria; Firmicutes; Bacilli; Lactobacillales; Streptococcaceae;
OC   Lactococcus; Lactococcus cremoris subsp. cremoris.
OX   NCBI_TaxID=272622;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=SK11;
RX   PubMed=17030793; DOI=10.1073/pnas.0607117103;
RA   Makarova K.S., Slesarev A., Wolf Y.I., Sorokin A., Mirkin B., Koonin E.V.,
RA   Pavlov A., Pavlova N., Karamychev V., Polouchine N., Shakhova V.,
RA   Grigoriev I., Lou Y., Rohksar D., Lucas S., Huang K., Goodstein D.M.,
RA   Hawkins T., Plengvidhya V., Welker D., Hughes J., Goh Y., Benson A.,
RA   Baldwin K., Lee J.-H., Diaz-Muniz I., Dosti B., Smeianov V., Wechter W.,
RA   Barabote R., Lorca G., Altermann E., Barrangou R., Ganesan B., Xie Y.,
RA   Rawsthorne H., Tamir D., Parker C., Breidt F., Broadbent J.R., Hutkins R.,
RA   O'Sullivan D., Steele J., Unlu G., Saier M.H. Jr., Klaenhammer T.,
RA   Richardson P., Kozyavkin S., Weimer B.C., Mills D.A.;
RT   "Comparative genomics of the lactic acid bacteria.";
RL   Proc. Natl. Acad. Sci. U.S.A. 103:15611-15616(2006).
CC   -!- FUNCTION: Transport of potassium into the cell. {ECO:0000255|HAMAP-
CC       Rule:MF_01522}.
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000255|HAMAP-Rule:MF_01522};
CC       Multi-pass membrane protein {ECO:0000255|HAMAP-Rule:MF_01522}.
CC   -!- SIMILARITY: Belongs to the HAK/KUP transporter (TC 2.A.72) family.
CC       {ECO:0000255|HAMAP-Rule:MF_01522}.
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DR   EMBL; CP000425; ABJ72210.1; -; Genomic_DNA.
DR   RefSeq; WP_011675762.1; NC_008527.1.
DR   AlphaFoldDB; Q031B2; -.
DR   EnsemblBacteria; ABJ72210; ABJ72210; LACR_0643.
DR   KEGG; llc:LACR_0643; -.
DR   HOGENOM; CLU_008142_4_1_9; -.
DR   OMA; VKYICIA; -.
DR   Proteomes; UP000000240; Chromosome.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0015079; F:potassium ion transmembrane transporter activity; IEA:UniProtKB-UniRule.
DR   HAMAP; MF_01522; Kup; 1.
DR   InterPro; IPR003855; K+_transporter.
DR   InterPro; IPR023051; K+_uptake_low_affin.
DR   PANTHER; PTHR30540; PTHR30540; 1.
DR   Pfam; PF02705; K_trans; 1.
PE   3: Inferred from homology;
KW   Cell membrane; Ion transport; Membrane; Potassium; Potassium transport;
KW   Transmembrane; Transmembrane helix; Transport.
FT   CHAIN           1..673
FT                   /note="Probable potassium transport system protein kup 1"
FT                   /id="PRO_0000279796"
FT   TRANSMEM        14..34
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01522"
FT   TRANSMEM        58..78
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01522"
FT   TRANSMEM        101..121
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01522"
FT   TRANSMEM        147..167
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01522"
FT   TRANSMEM        175..195
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01522"
FT   TRANSMEM        220..240
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01522"
FT   TRANSMEM        252..272
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01522"
FT   TRANSMEM        294..314
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01522"
FT   TRANSMEM        345..365
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01522"
FT   TRANSMEM        374..394
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01522"
FT   TRANSMEM        403..423
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01522"
FT   TRANSMEM        427..447
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01522"
SQ   SEQUENCE   673 AA;  75419 MW;  F4B1D3C9ED47AC55 CRC64;
     MGYQHNRSFN KATGAGFIIA MGIVYGDIGT SPLYTMESIV QGQGGLERIS ETSIIGALSL
     IIWTLTLITT VKYVWIALKA DNNHEGGIFS LFTLVRKYAK WLIIPAMIGG AALLSDGALT
     PAVTVTSAIE GLRSIPAFHE AFGQQQLPIV IITLAILAIL FLIQRFGTSI VGKVFGPVMF
     IWFSFFGITG LINLFGDFSV LQAINPYWAI HLLLSPENKA GIFVLGSVFL ATTGAEALYS
     DLGHVGRGNI HVSWPFVKVC IILSYCGQAA WLLQNRGKSL GDINPFFAVL PQSLIIFSVI
     LATLAAIIAS QALISGSFTL VSEAIRLKLL PRLRINYPGE SFGQLYIPAV NLGLWLAASF
     IVVYFQSSAH MEAAYGLAIT VTMLMTTILL TVYLAQHQKV KKVFVVLFFG AFIFIEGLFF
     AASAVKFLHG GYVVVILAAL ILFVMAIWHK SDQLFYKYLK SSNLNDYKEQ MNKLRKDESY
     DLYHTNVVYL TAKMDKEWID RSILYSILDK RPKKAEVYWF VKVNVTDEPY TSEYEVDMLG
     TDFIVCVNLY LGFHMRQEIP RYLRTIVTNL MESGRLPQQH QPYSIIPGRK VGDFRFILLE
     EKLINARQMP AFERFVLQTK EQIKKITASP ARWFGLHFSE VTVETVPLVL SDVRNLEIHE
     RISKENEVEN LSK