ID   ARCA_SALTY              Reviewed;         406 AA.
AC   Q8ZK33;
DT   01-MAR-2005, integrated into UniProtKB/Swiss-Prot.
DT   01-MAR-2002, sequence version 1.
DT   03-AUG-2022, entry version 99.
DE   RecName: Full=Arginine deiminase {ECO:0000255|HAMAP-Rule:MF_00242};
DE            Short=ADI {ECO:0000255|HAMAP-Rule:MF_00242};
DE            EC=3.5.3.6 {ECO:0000255|HAMAP-Rule:MF_00242};
DE   AltName: Full=Arginine dihydrolase {ECO:0000255|HAMAP-Rule:MF_00242};
DE            Short=AD {ECO:0000255|HAMAP-Rule:MF_00242};
GN   Name=arcA {ECO:0000255|HAMAP-Rule:MF_00242}; OrderedLocusNames=STM4467;
OS   Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC   Enterobacteriaceae; Salmonella.
OX   NCBI_TaxID=99287;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=LT2 / SGSC1412 / ATCC 700720;
RX   PubMed=11677609; DOI=10.1038/35101614;
RA   McClelland M., Sanderson K.E., Spieth J., Clifton S.W., Latreille P.,
RA   Courtney L., Porwollik S., Ali J., Dante M., Du F., Hou S., Layman D.,
RA   Leonard S., Nguyen C., Scott K., Holmes A., Grewal N., Mulvaney E.,
RA   Ryan E., Sun H., Florea L., Miller W., Stoneking T., Nhan M., Waterston R.,
RA   Wilson R.K.;
RT   "Complete genome sequence of Salmonella enterica serovar Typhimurium LT2.";
RL   Nature 413:852-856(2001).
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=H2O + L-arginine = L-citrulline + NH4(+);
CC         Xref=Rhea:RHEA:19597, ChEBI:CHEBI:15377, ChEBI:CHEBI:28938,
CC         ChEBI:CHEBI:32682, ChEBI:CHEBI:57743; EC=3.5.3.6;
CC         Evidence={ECO:0000255|HAMAP-Rule:MF_00242};
CC   -!- PATHWAY: Amino-acid degradation; L-arginine degradation via ADI
CC       pathway; carbamoyl phosphate from L-arginine: step 1/2.
CC       {ECO:0000255|HAMAP-Rule:MF_00242}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_00242}.
CC   -!- SIMILARITY: Belongs to the arginine deiminase family.
CC       {ECO:0000255|HAMAP-Rule:MF_00242}.
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DR   EMBL; AE006468; AAL23286.1; -; Genomic_DNA.
DR   RefSeq; NP_463327.1; NC_003197.2.
DR   RefSeq; WP_000410846.1; NC_003197.2.
DR   AlphaFoldDB; Q8ZK33; -.
DR   SMR; Q8ZK33; -.
DR   STRING; 99287.STM4467; -.
DR   PaxDb; Q8ZK33; -.
DR   EnsemblBacteria; AAL23286; AAL23286; STM4467.
DR   GeneID; 1255993; -.
DR   KEGG; stm:STM4467; -.
DR   PATRIC; fig|99287.12.peg.4701; -.
DR   HOGENOM; CLU_052662_0_0_6; -.
DR   OMA; ERATMHL; -.
DR   PhylomeDB; Q8ZK33; -.
DR   BioCyc; SENT99287:STM4467-MON; -.
DR   UniPathway; UPA00254; UER00364.
DR   Proteomes; UP000001014; Chromosome.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0016990; F:arginine deiminase activity; IBA:GO_Central.
DR   GO; GO:0019547; P:arginine catabolic process to ornithine; IEA:UniProtKB-UniPathway.
DR   GO; GO:0019546; P:arginine deiminase pathway; IBA:GO_Central.
DR   GO; GO:0018101; P:protein citrullination; IEA:GOC.
DR   HAMAP; MF_00242; Arg_deiminase; 1.
DR   InterPro; IPR003876; Arg_deiminase.
DR   PIRSF; PIRSF006356; Arg_deiminase; 1.
DR   PRINTS; PR01466; ARGDEIMINASE.
DR   TIGRFAMs; TIGR01078; arcA; 1.
PE   3: Inferred from homology;
KW   Arginine metabolism; Cytoplasm; Hydrolase; Reference proteome.
FT   CHAIN           1..406
FT                   /note="Arginine deiminase"
FT                   /id="PRO_0000182233"
FT   ACT_SITE        396
FT                   /note="Amidino-cysteine intermediate"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00242"
SQ   SEQUENCE   406 AA;  45562 MW;  F5F592877AD6B028 CRC64;
     MEKHFVGSEI GQLRSVMLHR PNLSLKRLTP SNCQELLFDD VLSVERAGEE HDIFANTLRQ
     QGIEVLLLTD LLTQTLDVAD AKAWLLDTQI SDYRLGPTFA ADIRAWLADM PHRELARHLS
     GGLTYGEIPA SIKNMVVDTH DINDFIMKPL PNHLFTRDTS CWIYNGVSIN PMAKPARQRE
     TNNLRAIYRW HPQFAGGDFI KYFGDEDINY DHATLEGGDV LVIGRGAVLI GMSERTTPQG
     VEFLAQALFK HRQAERVIAV ELPKHRSCMH LDTVMTHIDI DTFSVYPEVV RPDVQCWTLT
     PDGRGGLKRT QESTLVHALE TALGIDQVRL ITTGGDAFEA EREQWNDANN VLTLRPGVVV
     GYERNIWTNE KYDKAGITVL PIPGDELGRG RGGARCMSCP LERDGI