ID   KUP2_BIFLO              Reviewed;         736 AA.
AC   Q8G7Q3;
DT   27-SEP-2004, integrated into UniProtKB/Swiss-Prot.
DT   01-MAR-2003, sequence version 1.
DT   03-AUG-2022, entry version 92.
DE   RecName: Full=Probable potassium transport system protein kup 2;
GN   Name=kup2; OrderedLocusNames=BL0194;
OS   Bifidobacterium longum (strain NCC 2705).
OC   Bacteria; Actinobacteria; Bifidobacteriales; Bifidobacteriaceae;
OC   Bifidobacterium.
OX   NCBI_TaxID=206672;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=NCC 2705;
RX   PubMed=12381787; DOI=10.1073/pnas.212527599;
RA   Schell M.A., Karmirantzou M., Snel B., Vilanova D., Berger B., Pessi G.,
RA   Zwahlen M.-C., Desiere F., Bork P., Delley M., Pridmore R.D., Arigoni F.;
RT   "The genome sequence of Bifidobacterium longum reflects its adaptation to
RT   the human gastrointestinal tract.";
RL   Proc. Natl. Acad. Sci. U.S.A. 99:14422-14427(2002).
CC   -!- FUNCTION: Transport of potassium into the cell. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000250}; Multi-pass membrane
CC       protein {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the HAK/KUP transporter (TC 2.A.72) family.
CC       {ECO:0000305}.
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DR   EMBL; AE014295; AAN24048.1; -; Genomic_DNA.
DR   RefSeq; NP_695412.1; NC_004307.2.
DR   RefSeq; WP_011068672.1; NC_004307.2.
DR   AlphaFoldDB; Q8G7Q3; -.
DR   STRING; 206672.BL0194; -.
DR   EnsemblBacteria; AAN24048; AAN24048; BL0194.
DR   KEGG; blo:BL0194; -.
DR   PATRIC; fig|206672.9.peg.1495; -.
DR   HOGENOM; CLU_008142_4_1_11; -.
DR   OMA; TILLYEW; -.
DR   PhylomeDB; Q8G7Q3; -.
DR   Proteomes; UP000000439; Chromosome.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0015079; F:potassium ion transmembrane transporter activity; IEA:UniProtKB-UniRule.
DR   HAMAP; MF_01522; Kup; 1.
DR   InterPro; IPR003855; K+_transporter.
DR   InterPro; IPR023051; K+_uptake_low_affin.
DR   PANTHER; PTHR30540; PTHR30540; 1.
DR   Pfam; PF02705; K_trans; 1.
PE   3: Inferred from homology;
KW   Cell membrane; Ion transport; Membrane; Potassium; Potassium transport;
KW   Reference proteome; Transmembrane; Transmembrane helix; Transport.
FT   CHAIN           1..736
FT                   /note="Probable potassium transport system protein kup 2"
FT                   /id="PRO_0000208994"
FT   TRANSMEM        1..21
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        42..62
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        84..104
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        126..146
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        156..176
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        204..224
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        239..259
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        287..307
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        334..354
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        364..384
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        390..410
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        414..434
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   REGION          649..678
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          693..736
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        709..723
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   736 AA;  80558 MW;  BA291E3D79D68986 CRC64;
     MAIVALGVVY GDIGTSPLYT AQTFLAGQGG LGSVDREAVL GMLSLVFWSI TLITTVKYVL
     IAMRIDNNGE GGIFALYSLI RKYGAWLAIP AMLGGAAFLA DSVLTPAVSI SSAVEGLQTL
     PPLEGLFDEN PSLTLMITVV IIVILFSVQS RGTESIGKVF GSMVLVWFGF LAIVGVTNLS
     NDWSVFEALN PVYGIKFLFS PNNAAGIALM GTVFLSTTGA EALYSDMGHV GRGNIYFTWP
     FIKVALVLNY FGQGAWMLAN SDNPQYTAME SLNPFFQMMS PNVRYLAVIL SVSAGVIASQ
     ALITGAFTMV SEATRLNWMP HLQVRYPART RGQLYIPVVN GVLCVSTLAV LAIFKDSEHI
     SAAYGLALTI TMITTTVLLG VYLWHSGKRV GAIVFTVLFL AIQAMFFIAS MAKFLHGGWF
     TMLLTAAILF VMYTWNEGTK LERAQRRHMR PNDFLPALDK LHSDFRIPYF ADNIVYLTSD
     SETKRLDTDI FFSIFADHPK RARAWWAVSV ETTDEPFTRE YSVEDFGTNY IYRVRFRLGF
     KVSQSIPAYI HQIMHDLSKT GELPKQKSIY PKVDADPDIG TIRYVLIHKA LMPESKVSAR
     GALSLQAKYA IRHMAGSPVK WFGLAPYNPL VEVQPLFVST RRPPRLKRTD TAKTIPTPTP
     TRAVADPAAV PDPMDTTSGL GRLVQELDAA VSAEARKTAE AAAADAPAEQ GDKGDKGKAE
     NGKPAAKPQR SAKQKR