ID   KUP2_CUPNH              Reviewed;         633 AA.
AC   Q0K2K6;
DT   06-MAR-2007, integrated into UniProtKB/Swiss-Prot.
DT   03-OCT-2006, sequence version 1.
DT   25-MAY-2022, entry version 83.
DE   RecName: Full=Probable potassium transport system protein kup 2 {ECO:0000255|HAMAP-Rule:MF_01522};
GN   Name=kup2 {ECO:0000255|HAMAP-Rule:MF_01522}; OrderedLocusNames=H16_B0977;
OS   Cupriavidus necator (strain ATCC 17699 / DSM 428 / KCTC 22496 / NCIMB 10442
OS   / H16 / Stanier 337) (Ralstonia eutropha).
OC   Bacteria; Proteobacteria; Betaproteobacteria; Burkholderiales;
OC   Burkholderiaceae; Cupriavidus.
OX   NCBI_TaxID=381666;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 17699 / DSM 428 / KCTC 22496 / NCIMB 10442 / H16 / Stanier 337;
RX   PubMed=16964242; DOI=10.1038/nbt1244;
RA   Pohlmann A., Fricke W.F., Reinecke F., Kusian B., Liesegang H., Cramm R.,
RA   Eitinger T., Ewering C., Poetter M., Schwartz E., Strittmatter A., Voss I.,
RA   Gottschalk G., Steinbuechel A., Friedrich B., Bowien B.;
RT   "Genome sequence of the bioplastic-producing 'Knallgas' bacterium Ralstonia
RT   eutropha H16.";
RL   Nat. Biotechnol. 24:1257-1262(2006).
CC   -!- FUNCTION: Transport of potassium into the cell. {ECO:0000255|HAMAP-
CC       Rule:MF_01522}.
CC   -!- SUBCELLULAR LOCATION: Cell inner membrane {ECO:0000255|HAMAP-
CC       Rule:MF_01522}; Multi-pass membrane protein {ECO:0000255|HAMAP-
CC       Rule:MF_01522}.
CC   -!- SIMILARITY: Belongs to the HAK/KUP transporter (TC 2.A.72) family.
CC       {ECO:0000255|HAMAP-Rule:MF_01522}.
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DR   EMBL; AM260480; CAJ95768.1; -; Genomic_DNA.
DR   RefSeq; WP_011616928.1; NZ_CP039288.1.
DR   AlphaFoldDB; Q0K2K6; -.
DR   STRING; 381666.H16_B0977; -.
DR   EnsemblBacteria; CAJ95768; CAJ95768; H16_B0977.
DR   GeneID; 57646873; -.
DR   KEGG; reh:H16_B0977; -.
DR   eggNOG; COG3158; Bacteria.
DR   HOGENOM; CLU_008142_4_2_4; -.
DR   OMA; GHETIIP; -.
DR   OrthoDB; 589903at2; -.
DR   Proteomes; UP000008210; Chromosome 2.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0015079; F:potassium ion transmembrane transporter activity; IEA:UniProtKB-UniRule.
DR   HAMAP; MF_01522; Kup; 1.
DR   InterPro; IPR003855; K+_transporter.
DR   InterPro; IPR023051; K+_uptake_low_affin.
DR   PANTHER; PTHR30540; PTHR30540; 1.
DR   Pfam; PF02705; K_trans; 1.
PE   3: Inferred from homology;
KW   Cell inner membrane; Cell membrane; Ion transport; Membrane; Potassium;
KW   Potassium transport; Reference proteome; Transmembrane;
KW   Transmembrane helix; Transport.
FT   CHAIN           1..633
FT                   /note="Probable potassium transport system protein kup 2"
FT                   /id="PRO_0000279815"
FT   TRANSMEM        59..79
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01522"
FT   TRANSMEM        110..130
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01522"
FT   TRANSMEM        145..165
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01522"
FT   TRANSMEM        173..193
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01522"
FT   TRANSMEM        219..239
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01522"
FT   TRANSMEM        256..276
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01522"
FT   TRANSMEM        287..307
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01522"
FT   TRANSMEM        345..365
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01522"
FT   TRANSMEM        374..394
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01522"
FT   TRANSMEM        402..422
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01522"
FT   TRANSMEM        429..449
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01522"
SQ   SEQUENCE   633 AA;  67011 MW;  40176D54C78F9D26 CRC64;
     MNGETPDASH PQQSRAELTL AALGVVYGDI GTSPLYAVKE TFNPAHGIPL VTENILGGIS
     AILWALMVVV SLKYVILIMR ANNRGEGGIM ALLALALSSV KKVGRSPTPI LLVGLFGAAL
     FYGDAVLTPA MSVLSALEGI EVGTTALQPY VLPASVGVLI ALFLFQRHGT AAIGALFGPV
     TIVWFLALAA AGIHGIARYP AILGALSPLH ALGFVTQHGF ASFAVLGAVL LAFTGAEALY
     ADMGHFGSAP IRLAWFGLVF PALALNYLGQ GALIIVNAKA IENPFYLLYP SWALYPMVAL
     ATAATVIASQ ATISGAYSLT KQGIQLGYLP RMNVVHTSER AIGQIYIPTL NGMLLVAVLV
     AVLGFGSSSN LASAYGVAVT GTMLVTTLLT FFVIHYGWRY NLLLSLVATG FFIAVDMAFV
     SSSLLKVAEG GWFPLVVGAG IFVVMLTWVR GRQALLERLQ STDVPLKSFL DSLFLAPPPR
     VPGTAVFLTP TPDVVPHALM HNLNHNRVLH ERVVFLTVKM KDVPSVPATE CAAVEPLGHA
     CYRITLRFGF MNRPDVAQAL GALPPAAGLE FDIMDTSFFL SREAIVAAAG GPSGMASWRE
     RLFATMSRNA GNAADYFNIP ANRVIEIGTQ IKI