ID   KUP2_LACAC              Reviewed;         671 AA.
AC   Q5FLF5;
DT   12-APR-2005, integrated into UniProtKB/Swiss-Prot.
DT   01-MAR-2005, sequence version 1.
DT   03-AUG-2022, entry version 87.
DE   RecName: Full=Probable potassium transport system protein kup 2 {ECO:0000255|HAMAP-Rule:MF_01522};
GN   Name=kup2 {ECO:0000255|HAMAP-Rule:MF_01522}; OrderedLocusNames=LBA0590;
OS   Lactobacillus acidophilus (strain ATCC 700396 / NCK56 / N2 / NCFM).
OC   Bacteria; Firmicutes; Bacilli; Lactobacillales; Lactobacillaceae;
OC   Lactobacillus.
OX   NCBI_TaxID=272621;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 700396 / NCK56 / N2 / NCFM;
RX   PubMed=15671160; DOI=10.1073/pnas.0409188102;
RA   Altermann E., Russell W.M., Azcarate-Peril M.A., Barrangou R., Buck B.L.,
RA   McAuliffe O., Souther N., Dobson A., Duong T., Callanan M., Lick S.,
RA   Hamrick A., Cano R., Klaenhammer T.R.;
RT   "Complete genome sequence of the probiotic lactic acid bacterium
RT   Lactobacillus acidophilus NCFM.";
RL   Proc. Natl. Acad. Sci. U.S.A. 102:3906-3912(2005).
CC   -!- FUNCTION: Transport of potassium into the cell. {ECO:0000255|HAMAP-
CC       Rule:MF_01522}.
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000255|HAMAP-Rule:MF_01522};
CC       Multi-pass membrane protein {ECO:0000255|HAMAP-Rule:MF_01522}.
CC   -!- SIMILARITY: Belongs to the HAK/KUP transporter (TC 2.A.72) family.
CC       {ECO:0000255|HAMAP-Rule:MF_01522}.
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DR   EMBL; CP000033; AAV42469.1; -; Genomic_DNA.
DR   RefSeq; WP_011254197.1; NC_006814.3.
DR   RefSeq; YP_193500.1; NC_006814.3.
DR   AlphaFoldDB; Q5FLF5; -.
DR   STRING; 272621.LBA0590; -.
DR   PRIDE; Q5FLF5; -.
DR   EnsemblBacteria; AAV42469; AAV42469; LBA0590.
DR   KEGG; lac:LBA0590; -.
DR   PATRIC; fig|272621.13.peg.563; -.
DR   eggNOG; COG3158; Bacteria.
DR   HOGENOM; CLU_008142_4_1_9; -.
DR   OMA; AADQFEI; -.
DR   BioCyc; LACI272621:G1G49-614-MON; -.
DR   Proteomes; UP000006381; Chromosome.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0015079; F:potassium ion transmembrane transporter activity; IEA:UniProtKB-UniRule.
DR   HAMAP; MF_01522; Kup; 1.
DR   InterPro; IPR003855; K+_transporter.
DR   InterPro; IPR023051; K+_uptake_low_affin.
DR   PANTHER; PTHR30540; PTHR30540; 1.
DR   Pfam; PF02705; K_trans; 1.
PE   3: Inferred from homology;
KW   Cell membrane; Ion transport; Membrane; Potassium; Potassium transport;
KW   Reference proteome; Transmembrane; Transmembrane helix; Transport.
FT   CHAIN           1..671
FT                   /note="Probable potassium transport system protein kup 2"
FT                   /id="PRO_0000209021"
FT   TRANSMEM        12..32
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01522"
FT   TRANSMEM        56..76
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01522"
FT   TRANSMEM        99..119
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01522"
FT   TRANSMEM        139..159
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01522"
FT   TRANSMEM        172..192
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01522"
FT   TRANSMEM        218..238
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01522"
FT   TRANSMEM        251..271
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01522"
FT   TRANSMEM        296..316
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01522"
FT   TRANSMEM        345..365
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01522"
FT   TRANSMEM        374..394
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01522"
FT   TRANSMEM        400..420
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01522"
FT   TRANSMEM        429..449
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01522"
SQ   SEQUENCE   671 AA;  74681 MW;  A2EBBAD8CFFC05D2 CRC64;
     MNKITKKQKM SFAGLLIAIG IVYGDIGTSP LYVMKSIVTE NGGIANVNRE LIVGSISLIL
     WTVTLLTTVK YVMIALKATN HGEGGIFSLY ALVRKRAKWL VIPALIGGAA LLADGTLTPA
     VTVTTSIEGL KNMRFGDVIP VPSQEVVIMI TIIILVILFS IQRMGTSVIG KAFGPIMLIW
     FTFLGVVGIA NLSHDWSLLE AINPIHAIRI LVSPANKVGI LILGSVFLAT TGAEALYSDV
     GHVSKANIIG SWPYIFVCLS LNYLGQGAWI LHNVSYHAGN GDFNPFFEVV PSNLRLFAIA
     LATIAAIIAS QALITGSFTL VAEASSLKFL PRMNIIYPST EKGQIYIPLI NKMICVVTVA
     IVFLFRTSHH MEAAYGLAIT VTMLMTTILL FEYLGKKGKP LYLRVIFLIA FAFIEGMFLI
     SSLTKFLHGG YVTVLIAGFI LVIMYVWFYG NKIRDKREAK NAYVRLDEYT EMLTDLSHCE
     DYPVYATNVV YMAKVKYNKF IKREMLYSIL DKRPKRAKAY WFVTVNVTNE PYTAEYAVNT
     YGTKNVINVQ LYLGFRKQTS VNVYLRQIVH ELIADGTIEA QPQRFTTTPG RDVGDFSFVI
     VNDVISPLTK LTGYEKFMVE ARVWLQNLSS NPASWFGLEY ADTVVERVPL ILGKHQESYI
     KRIKPKKQTK K