ID   KUP2_LACJO              Reviewed;         665 AA.
AC   Q74LN2;
DT   27-SEP-2004, integrated into UniProtKB/Swiss-Prot.
DT   05-JUL-2004, sequence version 1.
DT   25-MAY-2022, entry version 107.
DE   RecName: Full=Probable potassium transport system protein kup 2 {ECO:0000255|HAMAP-Rule:MF_01522};
GN   Name=kup2 {ECO:0000255|HAMAP-Rule:MF_01522}; OrderedLocusNames=LJ_0151;
OS   Lactobacillus johnsonii (strain CNCM I-12250 / La1 / NCC 533).
OC   Bacteria; Firmicutes; Bacilli; Lactobacillales; Lactobacillaceae;
OC   Lactobacillus.
OX   NCBI_TaxID=257314;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=CNCM I-1225 / La1 / NCC 533;
RX   PubMed=14983040; DOI=10.1073/pnas.0307327101;
RA   Pridmore R.D., Berger B., Desiere F., Vilanova D., Barretto C.,
RA   Pittet A.-C., Zwahlen M.-C., Rouvet M., Altermann E., Barrangou R.,
RA   Mollet B., Mercenier A., Klaenhammer T., Arigoni F., Schell M.A.;
RT   "The genome sequence of the probiotic intestinal bacterium Lactobacillus
RT   johnsonii NCC 533.";
RL   Proc. Natl. Acad. Sci. U.S.A. 101:2512-2517(2004).
CC   -!- FUNCTION: Transport of potassium into the cell. {ECO:0000255|HAMAP-
CC       Rule:MF_01522}.
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000255|HAMAP-Rule:MF_01522};
CC       Multi-pass membrane protein {ECO:0000255|HAMAP-Rule:MF_01522}.
CC   -!- SIMILARITY: Belongs to the HAK/KUP transporter (TC 2.A.72) family.
CC       {ECO:0000255|HAMAP-Rule:MF_01522}.
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DR   EMBL; AE017198; AAS08133.1; -; Genomic_DNA.
DR   RefSeq; WP_004898620.1; NC_005362.1.
DR   AlphaFoldDB; Q74LN2; -.
DR   STRING; 257314.LJ_0151; -.
DR   EnsemblBacteria; AAS08133; AAS08133; LJ_0151.
DR   GeneID; 66434474; -.
DR   KEGG; ljo:LJ_0151; -.
DR   eggNOG; COG3158; Bacteria.
DR   HOGENOM; CLU_008142_4_1_9; -.
DR   OMA; VMLVIWD; -.
DR   Proteomes; UP000000581; Chromosome.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0015079; F:potassium ion transmembrane transporter activity; IEA:UniProtKB-UniRule.
DR   HAMAP; MF_01522; Kup; 1.
DR   InterPro; IPR003855; K+_transporter.
DR   InterPro; IPR023051; K+_uptake_low_affin.
DR   PANTHER; PTHR30540; PTHR30540; 2.
DR   Pfam; PF02705; K_trans; 1.
PE   3: Inferred from homology;
KW   Cell membrane; Ion transport; Membrane; Potassium; Potassium transport;
KW   Reference proteome; Transmembrane; Transmembrane helix; Transport.
FT   CHAIN           1..665
FT                   /note="Probable potassium transport system protein kup 2"
FT                   /id="PRO_0000209023"
FT   TRANSMEM        13..33
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01522"
FT   TRANSMEM        55..75
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01522"
FT   TRANSMEM        98..118
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01522"
FT   TRANSMEM        138..158
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01522"
FT   TRANSMEM        167..187
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01522"
FT   TRANSMEM        217..237
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01522"
FT   TRANSMEM        250..270
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01522"
FT   TRANSMEM        295..315
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01522"
FT   TRANSMEM        344..364
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01522"
FT   TRANSMEM        375..395
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01522"
FT   TRANSMEM        400..420
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01522"
FT   TRANSMEM        428..448
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01522"
SQ   SEQUENCE   665 AA;  73826 MW;  2D5A067CCA60E79A CRC64;
     MNNGVRKKVT LAGLLVSIGI VYGDIGTSPL YVMKAIVNEN GGIASVNREY IVGSISLILW
     TITLLTTVKY VLIALKATNH GEGGIFSLYA LVRKKAKWLV LPALIGGAAL LADGTLTPAV
     TVTTAIEGLK NMRFGNDIPV PNQNSVLIIT IIILLFLFSI QRMGTSIIGK TFGPIMLIWF
     TFLGLTGAMN LSHDLSLLEA LNPVLAVKIL FSPANKVGVL ILGAVFLATT GAEALYSDVG
     HVGKGNIMAS WPYVFICLAL NYLGQGVWIL ENPNYHAGNT DFNPFFEALP SQWKFFAIIL
     ATLAAIIASQ ALITGSFTLV SEASGLKFLP RMKIIYPSTE QGQIFIPSIN KMLCAATIGI
     VFLFKTSEHM EAAYGLAITV TMLMTTILLF EYLSLKKVNI LLRLVFLFLF GAIESMFLIS
     SLAKFLHGGY VTVIIAAFIG AIMYIWYFGN KVRDRREAKN AYVRLDEYTS MLSNLSHDDS
     VPLYATNLVY MAKVKYNKFI KRDILYSILD KRPKRAHAYW FVTVNVTNEP FTAEYAINTY
     GTKNVINVQL YLGFKQQQKV NVYLRQIVHE LIKDGTIESQ PQEYTTTPGR DVGDFKFVIV
     NDVISPQTQL NTYEKWLVES RVWLQNLSSN PAVWFGLEYA DTVVERVPLI LGSQNIKSIQ
     RTKLK