ID   KUP2_LACPL              Reviewed;         680 AA.
AC   Q88SV0; F9UTG9;
DT   27-SEP-2004, integrated into UniProtKB/Swiss-Prot.
DT   01-JUN-2003, sequence version 1.
DT   03-AUG-2022, entry version 93.
DE   RecName: Full=Probable potassium transport system protein kup 2 {ECO:0000255|HAMAP-Rule:MF_01522};
GN   Name=kup2 {ECO:0000255|HAMAP-Rule:MF_01522}; OrderedLocusNames=lp_3279;
OS   Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)
OS   (Lactobacillus plantarum).
OC   Bacteria; Firmicutes; Bacilli; Lactobacillales; Lactobacillaceae;
OC   Lactiplantibacillus.
OX   NCBI_TaxID=220668;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC BAA-793 / NCIMB 8826 / WCFS1;
RX   PubMed=12566566; DOI=10.1073/pnas.0337704100;
RA   Kleerebezem M., Boekhorst J., van Kranenburg R., Molenaar D., Kuipers O.P.,
RA   Leer R., Tarchini R., Peters S.A., Sandbrink H.M., Fiers M.W.E.J.,
RA   Stiekema W., Klein Lankhorst R.M., Bron P.A., Hoffer S.M.,
RA   Nierop Groot M.N., Kerkhoven R., De Vries M., Ursing B., De Vos W.M.,
RA   Siezen R.J.;
RT   "Complete genome sequence of Lactobacillus plantarum WCFS1.";
RL   Proc. Natl. Acad. Sci. U.S.A. 100:1990-1995(2003).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], AND GENOME REANNOTATION.
RC   STRAIN=ATCC BAA-793 / NCIMB 8826 / WCFS1;
RX   PubMed=22156394; DOI=10.1128/jb.06275-11;
RA   Siezen R.J., Francke C., Renckens B., Boekhorst J., Wels M.,
RA   Kleerebezem M., van Hijum S.A.;
RT   "Complete resequencing and reannotation of the Lactobacillus plantarum
RT   WCFS1 genome.";
RL   J. Bacteriol. 194:195-196(2012).
CC   -!- FUNCTION: Transport of potassium into the cell. {ECO:0000255|HAMAP-
CC       Rule:MF_01522}.
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000255|HAMAP-Rule:MF_01522};
CC       Multi-pass membrane protein {ECO:0000255|HAMAP-Rule:MF_01522}.
CC   -!- SIMILARITY: Belongs to the HAK/KUP transporter (TC 2.A.72) family.
CC       {ECO:0000255|HAMAP-Rule:MF_01522}.
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DR   EMBL; AL935263; CCC80287.1; -; Genomic_DNA.
DR   RefSeq; WP_003643475.1; NC_004567.2.
DR   RefSeq; YP_004890801.1; NC_004567.2.
DR   AlphaFoldDB; Q88SV0; -.
DR   EnsemblBacteria; CCC80287; CCC80287; lp_3279.
DR   GeneID; 57026550; -.
DR   GeneID; 66450815; -.
DR   KEGG; lpl:lp_3279; -.
DR   PATRIC; fig|220668.9.peg.2736; -.
DR   eggNOG; COG3158; Bacteria.
DR   HOGENOM; CLU_008142_4_1_9; -.
DR   OMA; TILLYEW; -.
DR   PhylomeDB; Q88SV0; -.
DR   BioCyc; LPLA220668:G1GW0-2775-MON; -.
DR   Proteomes; UP000000432; Chromosome.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0015079; F:potassium ion transmembrane transporter activity; IEA:UniProtKB-UniRule.
DR   HAMAP; MF_01522; Kup; 1.
DR   InterPro; IPR003855; K+_transporter.
DR   InterPro; IPR023051; K+_uptake_low_affin.
DR   PANTHER; PTHR30540; PTHR30540; 1.
DR   Pfam; PF02705; K_trans; 1.
PE   3: Inferred from homology;
KW   Cell membrane; Ion transport; Membrane; Potassium; Potassium transport;
KW   Reference proteome; Transmembrane; Transmembrane helix; Transport.
FT   CHAIN           1..680
FT                   /note="Probable potassium transport system protein kup 2"
FT                   /id="PRO_0000209028"
FT   TRANSMEM        12..32
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01522"
FT   TRANSMEM        55..75
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01522"
FT   TRANSMEM        98..118
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01522"
FT   TRANSMEM        143..163
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01522"
FT   TRANSMEM        170..190
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01522"
FT   TRANSMEM        216..236
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01522"
FT   TRANSMEM        249..269
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01522"
FT   TRANSMEM        288..308
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01522"
FT   TRANSMEM        345..365
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01522"
FT   TRANSMEM        374..394
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01522"
FT   TRANSMEM        402..422
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01522"
FT   TRANSMEM        428..448
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01522"
SQ   SEQUENCE   680 AA;  75704 MW;  7C5066E962370EA8 CRC64;
     MRKQRIQERS LIGMLITLGV VYGDIGTSPL YVMNALINDA GQLKNATPDY VIGSVSLIFW
     TLMLITTVKY VLIALRADNH HEGGIFALYA LVRHRAKWLI FVALIGGAAL LADGTLTPAV
     TVTSAVEGLK GLPKLGAFSQ YPWLVPLTVT VILLVLFMIQ GFGTAVVGRS FGPMMLLWFT
     VIGIFGLINI SQAPVILKAF SPVYAVQVLF NPANKMGIFI LGSVFLATTG AEALYSDMGH
     VGKANIDATW PFVYTTLILN YLGQGAWMLT HYQDAAWRNA TNVNPFYAMV PAGGQIAMII
     LATAAAIIAS QALITGSYTL VDEAVGLKFL PRMIIKHPSN VRSQIYIGAI NWLLCLVTLG
     IVWLFQTSAH MEAAYGLAIT LTMLMTTILL SQWIHMKGHR ALALALLFGF GALETVFLTA
     SLTKFIHGGY LTLGLTLVIF LIMVVWFFGN RRRLRYNQAN EQISLLDYRN QLIQLSHDDH
     LPVFATNLVY LAKVDHQHRV KRSILYSILD KRPKRAKVYW FITINETNRP YDCSYSIDML
     GTRNIVEVQL NLGFRKSQHI NLYLRQIVTN LIADHSIDPQ YSRYGITQPR QVGDFKFVVQ
     NQQIMDLASN PTMGQFDRLL IGGRVLLQNI TPSPAIWYGL AFSDVLEETI PLFTKPATDA
     TLTNLTVHHA RTPQRNSRQP