ID   KUP2_LEGPA              Reviewed;         625 AA.
AC   Q5X3H2;
DT   01-FEB-2005, integrated into UniProtKB/Swiss-Prot.
DT   23-NOV-2004, sequence version 1.
DT   25-MAY-2022, entry version 89.
DE   RecName: Full=Probable potassium transport system protein kup 2 {ECO:0000255|HAMAP-Rule:MF_01522};
GN   Name=kup2 {ECO:0000255|HAMAP-Rule:MF_01522}; OrderedLocusNames=lpp2064;
OS   Legionella pneumophila (strain Paris).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Legionellales;
OC   Legionellaceae; Legionella.
OX   NCBI_TaxID=297246;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Paris;
RX   PubMed=15467720; DOI=10.1038/ng1447;
RA   Cazalet C., Rusniok C., Brueggemann H., Zidane N., Magnier A., Ma L.,
RA   Tichit M., Jarraud S., Bouchier C., Vandenesch F., Kunst F., Etienne J.,
RA   Glaser P., Buchrieser C.;
RT   "Evidence in the Legionella pneumophila genome for exploitation of host
RT   cell functions and high genome plasticity.";
RL   Nat. Genet. 36:1165-1173(2004).
CC   -!- FUNCTION: Transport of potassium into the cell. {ECO:0000255|HAMAP-
CC       Rule:MF_01522}.
CC   -!- SUBCELLULAR LOCATION: Cell inner membrane {ECO:0000255|HAMAP-
CC       Rule:MF_01522}; Multi-pass membrane protein {ECO:0000255|HAMAP-
CC       Rule:MF_01522}.
CC   -!- SIMILARITY: Belongs to the HAK/KUP transporter (TC 2.A.72) family.
CC       {ECO:0000255|HAMAP-Rule:MF_01522}.
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DR   EMBL; CR628336; CAH13216.1; -; Genomic_DNA.
DR   RefSeq; WP_015961280.1; NC_006368.1.
DR   AlphaFoldDB; Q5X3H2; -.
DR   KEGG; lpp:lpp2064; -.
DR   LegioList; lpp2064; -.
DR   HOGENOM; CLU_008142_4_2_6; -.
DR   OMA; GHETIIP; -.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0015079; F:potassium ion transmembrane transporter activity; IEA:UniProtKB-UniRule.
DR   HAMAP; MF_01522; Kup; 1.
DR   InterPro; IPR003855; K+_transporter.
DR   InterPro; IPR023051; K+_uptake_low_affin.
DR   PANTHER; PTHR30540; PTHR30540; 1.
DR   Pfam; PF02705; K_trans; 1.
PE   3: Inferred from homology;
KW   Cell inner membrane; Cell membrane; Ion transport; Membrane; Potassium;
KW   Potassium transport; Transmembrane; Transmembrane helix; Transport.
FT   CHAIN           1..625
FT                   /note="Probable potassium transport system protein kup 2"
FT                   /id="PRO_0000209030"
FT   TRANSMEM        15..35
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01522"
FT   TRANSMEM        52..72
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01522"
FT   TRANSMEM        98..118
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01522"
FT   TRANSMEM        134..154
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01522"
FT   TRANSMEM        164..184
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01522"
FT   TRANSMEM        212..232
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01522"
FT   TRANSMEM        246..266
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01522"
FT   TRANSMEM        284..304
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01522"
FT   TRANSMEM        336..356
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01522"
FT   TRANSMEM        365..385
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01522"
FT   TRANSMEM        394..414
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01522"
FT   TRANSMEM        417..437
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01522"
SQ   SEQUENCE   625 AA;  70886 MW;  C39C4D67172ECD39 CRC64;
     MMNESLTEKR NELSLSFAAL GVVFGDIGTS PLYAFGQVIK YFPINDHNIY GILSLIFWSL
     IIIVSIKYLV IVFRADNDGE GGIIALAGVI RQKIKQPGGW LLFITLVGIG LIIGDGMLTP
     AISILSAVEG LESLSPNLAK YVLPVTLIIL FFLFKMQSIG TGKIGVYFAP VMLVWFITIG
     ILGFLQIIQN PKVLMAINPY YAINFFMIHK YFALFILGGV FLVMTGGEAL FADLGHFGKK
     AIRTGWFAVA LPALLLCYFG QGAFVLMHTE DIKYPFFSLS PDWFLPVMII LATLATIIAS
     QAIISAAFSI LKQASLLNLI PRLKIVFTSK FEKGEVYLPL INFILALGTC SLVVIFKSSS
     NLADAYGIAV NLDMLITTVL VGIIAYRCWS WHAFKILIFL LILIIELAFF AGNIPKLLTG
     GWIPILIAFL GFVVMYTWHC GFEKLRELHH RDALMDAFII DELNQNKISR QPGMGLYIID
     PYDCEGESLL HHLRLNRIFF ENMVFVSIKI ENKPYIPIED KFELIKKAEG FYLIFIHYGF
     TENINLPNEL DEMFKRVYLP FDIIKNKLIY FIEIVFVEMT GERQKHMYLW QKHFFSLMIR
     NAVPDIQFYQ LPYNNTIAIG TYYQF