ID   KUP2_LEGPH              Reviewed;         625 AA.
AC   Q5ZTN5;
DT   01-FEB-2005, integrated into UniProtKB/Swiss-Prot.
DT   23-NOV-2004, sequence version 1.
DT   25-MAY-2022, entry version 88.
DE   RecName: Full=Probable potassium transport system protein kup 2 {ECO:0000255|HAMAP-Rule:MF_01522};
GN   Name=kup2 {ECO:0000255|HAMAP-Rule:MF_01522}; OrderedLocusNames=lpg2126;
OS   Legionella pneumophila subsp. pneumophila (strain Philadelphia 1 / ATCC
OS   33152 / DSM 7513).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Legionellales;
OC   Legionellaceae; Legionella.
OX   NCBI_TaxID=272624;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Philadelphia 1 / ATCC 33152 / DSM 7513;
RX   PubMed=15448271; DOI=10.1126/science.1099776;
RA   Chien M., Morozova I., Shi S., Sheng H., Chen J., Gomez S.M., Asamani G.,
RA   Hill K., Nuara J., Feder M., Rineer J., Greenberg J.J., Steshenko V.,
RA   Park S.H., Zhao B., Teplitskaya E., Edwards J.R., Pampou S., Georghiou A.,
RA   Chou I.-C., Iannuccilli W., Ulz M.E., Kim D.H., Geringer-Sameth A.,
RA   Goldsberry C., Morozov P., Fischer S.G., Segal G., Qu X., Rzhetsky A.,
RA   Zhang P., Cayanis E., De Jong P.J., Ju J., Kalachikov S., Shuman H.A.,
RA   Russo J.J.;
RT   "The genomic sequence of the accidental pathogen Legionella pneumophila.";
RL   Science 305:1966-1968(2004).
CC   -!- FUNCTION: Transport of potassium into the cell. {ECO:0000255|HAMAP-
CC       Rule:MF_01522}.
CC   -!- SUBCELLULAR LOCATION: Cell inner membrane {ECO:0000255|HAMAP-
CC       Rule:MF_01522}; Multi-pass membrane protein {ECO:0000255|HAMAP-
CC       Rule:MF_01522}.
CC   -!- SIMILARITY: Belongs to the HAK/KUP transporter (TC 2.A.72) family.
CC       {ECO:0000255|HAMAP-Rule:MF_01522}.
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DR   EMBL; AE017354; AAU28192.1; -; Genomic_DNA.
DR   RefSeq; WP_010947837.1; NC_002942.5.
DR   RefSeq; YP_096139.1; NC_002942.5.
DR   AlphaFoldDB; Q5ZTN5; -.
DR   STRING; 272624.lpg2126; -.
DR   PaxDb; Q5ZTN5; -.
DR   EnsemblBacteria; AAU28192; AAU28192; lpg2126.
DR   GeneID; 66491258; -.
DR   KEGG; lpn:lpg2126; -.
DR   PATRIC; fig|272624.6.peg.2229; -.
DR   eggNOG; COG3158; Bacteria.
DR   HOGENOM; CLU_008142_4_2_6; -.
DR   OMA; GHETIIP; -.
DR   Proteomes; UP000000609; Chromosome.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0015079; F:potassium ion transmembrane transporter activity; IEA:UniProtKB-UniRule.
DR   HAMAP; MF_01522; Kup; 1.
DR   InterPro; IPR003855; K+_transporter.
DR   InterPro; IPR023051; K+_uptake_low_affin.
DR   PANTHER; PTHR30540; PTHR30540; 1.
DR   Pfam; PF02705; K_trans; 1.
PE   3: Inferred from homology;
KW   Cell inner membrane; Cell membrane; Ion transport; Membrane; Potassium;
KW   Potassium transport; Reference proteome; Transmembrane;
KW   Transmembrane helix; Transport.
FT   CHAIN           1..625
FT                   /note="Probable potassium transport system protein kup 2"
FT                   /id="PRO_0000209033"
FT   TRANSMEM        15..35
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01522"
FT   TRANSMEM        52..72
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01522"
FT   TRANSMEM        98..118
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01522"
FT   TRANSMEM        134..154
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01522"
FT   TRANSMEM        164..184
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01522"
FT   TRANSMEM        203..223
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01522"
FT   TRANSMEM        246..266
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01522"
FT   TRANSMEM        284..304
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01522"
FT   TRANSMEM        336..356
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01522"
FT   TRANSMEM        365..385
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01522"
FT   TRANSMEM        394..414
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01522"
FT   TRANSMEM        417..437
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01522"
SQ   SEQUENCE   625 AA;  71098 MW;  DAD951FFA381E76E CRC64;
     MMNESSTEKK NELSLSFAAL GVVFGDIGTS PLYAFGQVIK YFPINDHNIY GILSLIFWSL
     IIIVSIKYLV IVFRADNDGE GGIIALAGLI RQKIKKPGGW LLFITLVGIG LIIGDGILTP
     AISILSAVEG LESLSPNLAK YVLPVTLIIL FFLFKMQSIG TGKIGIYFAP VMLIWFITIG
     VLGFLQIIQN PKVLMAINPY YAIYFFMIHK YFALFILGGV FLVMTGGEAL FADLGHFGKK
     AIRTGWFAVA LPALLLCYFG QGAFVLMHIE YIKYPFFSLS PDWFLPVMII LATIATIIAS
     QAIISAAFSI LKQASLLNLI PRLKIIYTSK FEKGEVYLPL INFILALGTC SLVVIFKSSS
     NLADAYGIAV NLDMLITTVL VGIIAYYCWN WHAFKVMIFP LILVIELAFF AGNIPKLLTG
     GWIPILIAFL GFVVMYTWHC GFEKLRELHH RDALMDAFII DELNQNKISR QSGMGLYIID
     PYDCEGESLL HHLRLNRIFF ENMIFVSIKI ENKPYIPIED KFELIKKAEG FYLIFIHYGF
     TENINLPNEL DEMFKRVYLP FEIIKNKLIY FIEIVFVEMT RERQKHMYMW QKHLFSLMIR
     NAVPDIQFYR LPYNKTIAIG TYYQL