ID   KUP3_CUPNH              Reviewed;         632 AA.
AC   Q7WXK8;
DT   27-SEP-2004, integrated into UniProtKB/Swiss-Prot.
DT   01-OCT-2003, sequence version 1.
DT   25-MAY-2022, entry version 105.
DE   RecName: Full=Probable potassium transport system protein kup 3;
GN   Name=kup3; OrderedLocusNames=PHG116;
OS   Cupriavidus necator (strain ATCC 17699 / DSM 428 / KCTC 22496 / NCIMB 10442
OS   / H16 / Stanier 337) (Ralstonia eutropha).
OG   Plasmid megaplasmid pHG1.
OC   Bacteria; Proteobacteria; Betaproteobacteria; Burkholderiales;
OC   Burkholderiaceae; Cupriavidus.
OX   NCBI_TaxID=381666;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 17699 / DSM 428 / KCTC 22496 / NCIMB 10442 / H16 / Stanier 337;
RX   PubMed=12948488; DOI=10.1016/s0022-2836(03)00894-5;
RA   Schwartz E., Henne A., Cramm R., Eitinger T., Friedrich B., Gottschalk G.;
RT   "Complete nucleotide sequence of pHG1: a Ralstonia eutropha H16 megaplasmid
RT   encoding key enzymes of H(2)-based lithoautotrophy and anaerobiosis.";
RL   J. Mol. Biol. 332:369-383(2003).
CC   -!- FUNCTION: Transport of potassium into the cell. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cell inner membrane {ECO:0000250}; Multi-pass
CC       membrane protein {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the HAK/KUP transporter (TC 2.A.72) family.
CC       {ECO:0000305}.
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DR   EMBL; AY305378; AAP85869.1; -; Genomic_DNA.
DR   RefSeq; WP_011154037.1; NZ_CP039289.1.
DR   AlphaFoldDB; Q7WXK8; -.
DR   STRING; 381666.PHG116; -.
DR   EnsemblBacteria; AAP85869; AAP85869; PHG116.
DR   GeneID; 39976705; -.
DR   KEGG; reh:PHG116; -.
DR   PATRIC; fig|381666.6.peg.86; -.
DR   eggNOG; COG3158; Bacteria.
DR   HOGENOM; CLU_008142_4_2_4; -.
DR   OMA; AADQFEI; -.
DR   OrthoDB; 589903at2; -.
DR   Proteomes; UP000008210; Plasmid megaplasmid pHG1.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0015079; F:potassium ion transmembrane transporter activity; IEA:UniProtKB-UniRule.
DR   HAMAP; MF_01522; Kup; 1.
DR   InterPro; IPR003855; K+_transporter.
DR   InterPro; IPR023051; K+_uptake_low_affin.
DR   PANTHER; PTHR30540; PTHR30540; 1.
DR   Pfam; PF02705; K_trans; 1.
PE   3: Inferred from homology;
KW   Cell inner membrane; Cell membrane; Ion transport; Membrane; Plasmid;
KW   Potassium; Potassium transport; Reference proteome; Transmembrane;
KW   Transmembrane helix; Transport.
FT   CHAIN           1..632
FT                   /note="Probable potassium transport system protein kup 3"
FT                   /id="PRO_0000208990"
FT   TRANSMEM        19..39
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        59..79
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        110..130
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        146..166
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        178..198
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        213..233
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        256..276
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        298..318
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        346..366
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        373..393
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        403..423
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        428..448
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   632 AA;  68830 MW;  DCBFDC098BFCC1B2 CRC64;
     MTQSATAHYF VESPSTGALV LGAVGVVFGD IGTSPLYALK ECFSKEHGIA FSPDAVLGVI
     SILFWAMIIV VSIKYVVFVM RADNDGEGGV LALMALVLRT VAQRSRKAKI LMMLGIFGAC
     MFYGDAVITP AISVLSAVEG LEIAAPQLSQ FVIPITLVIL AALFLIQRHG TAAVGKLFGP
     IMTTWFVALG ALGILNLVQA PEILKSINPY YAISFLVEHA LQAFIVLGSV FLVLTGAEAL
     YVDMGHFGAR PIRIGWFVLV MPCLILNYFG QGAMLLHNPA GVENPFFLMV PELLQLPMVL
     LATSATVIAS QAVISGAFSL TSQAIQLGFV PRMRVLYTSA AEIGQIYLPV VNWLLLVLVI
     GVVISFKKSE NLAAAYGIAV TTTMVITTFL AAVCMRNVWK WDPALVAVLG TSFLLVDLAF
     FAANLLKIAE GGWFPLLLGS AAFFMLMTWY SGRKLLRARS LEDGIPLEPF IAGLLAHPPH
     RVEGTAVFLT GSIDTVPVSL LHNLKHNRVL HERVVFLTFV TRDIPYVDDD QRVSCKDLGG
     GAFILKSEYG FKETPDVQKV LDLADRKLGM HFELMETSFF IARESVIPSR LPGMPMWRES
     LFAWMHQNGA KPSDFFQIPA NRVVELGTKV EI