ID   KUP_ACIF2               Reviewed;         644 AA.
AC   B7JBL0;
DT   14-APR-2009, integrated into UniProtKB/Swiss-Prot.
DT   10-FEB-2009, sequence version 1.
DT   25-MAY-2022, entry version 66.
DE   RecName: Full=Probable potassium transport system protein kup {ECO:0000255|HAMAP-Rule:MF_01522};
GN   Name=kup {ECO:0000255|HAMAP-Rule:MF_01522}; OrderedLocusNames=AFE_1753;
OS   Acidithiobacillus ferrooxidans (strain ATCC 23270 / DSM 14882 / CIP 104768
OS   / NCIMB 8455) (Ferrobacillus ferrooxidans (strain ATCC 23270)).
OC   Bacteria; Proteobacteria; Acidithiobacillia; Acidithiobacillales;
OC   Acidithiobacillaceae; Acidithiobacillus.
OX   NCBI_TaxID=243159;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 23270 / DSM 14882 / CIP 104768 / NCIMB 8455;
RX   PubMed=19077236; DOI=10.1186/1471-2164-9-597;
RA   Valdes J., Pedroso I., Quatrini R., Dodson R.J., Tettelin H., Blake R. II,
RA   Eisen J.A., Holmes D.S.;
RT   "Acidithiobacillus ferrooxidans metabolism: from genome sequence to
RT   industrial applications.";
RL   BMC Genomics 9:597-597(2008).
CC   -!- FUNCTION: Transport of potassium into the cell. {ECO:0000255|HAMAP-
CC       Rule:MF_01522}.
CC   -!- SUBCELLULAR LOCATION: Cell inner membrane {ECO:0000255|HAMAP-
CC       Rule:MF_01522}; Multi-pass membrane protein {ECO:0000255|HAMAP-
CC       Rule:MF_01522}.
CC   -!- SIMILARITY: Belongs to the HAK/KUP transporter (TC 2.A.72) family.
CC       {ECO:0000255|HAMAP-Rule:MF_01522}.
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DR   EMBL; CP001219; ACK78640.1; -; Genomic_DNA.
DR   RefSeq; WP_012607219.1; NC_011761.1.
DR   AlphaFoldDB; B7JBL0; -.
DR   STRING; 243159.AFE_1753; -.
DR   PaxDb; B7JBL0; -.
DR   EnsemblBacteria; ACK78640; ACK78640; AFE_1753.
DR   KEGG; afr:AFE_1753; -.
DR   eggNOG; COG3158; Bacteria.
DR   HOGENOM; CLU_008142_4_2_6; -.
DR   OMA; FDTCMVT; -.
DR   OrthoDB; 589903at2; -.
DR   Proteomes; UP000001362; Chromosome.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0015079; F:potassium ion transmembrane transporter activity; IEA:UniProtKB-UniRule.
DR   HAMAP; MF_01522; Kup; 1.
DR   InterPro; IPR003855; K+_transporter.
DR   InterPro; IPR023051; K+_uptake_low_affin.
DR   PANTHER; PTHR30540; PTHR30540; 1.
DR   Pfam; PF02705; K_trans; 1.
PE   3: Inferred from homology;
KW   Cell inner membrane; Cell membrane; Ion transport; Membrane; Potassium;
KW   Potassium transport; Reference proteome; Transmembrane;
KW   Transmembrane helix; Transport.
FT   CHAIN           1..644
FT                   /note="Probable potassium transport system protein kup"
FT                   /id="PRO_1000190254"
FT   TRANSMEM        10..30
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01522"
FT   TRANSMEM        56..76
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01522"
FT   TRANSMEM        106..126
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01522"
FT   TRANSMEM        143..163
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01522"
FT   TRANSMEM        175..195
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01522"
FT   TRANSMEM        212..232
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01522"
FT   TRANSMEM        252..272
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01522"
FT   TRANSMEM        282..302
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01522"
FT   TRANSMEM        343..363
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01522"
FT   TRANSMEM        371..391
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01522"
FT   TRANSMEM        403..423
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01522"
FT   TRANSMEM        425..445
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01522"
SQ   SEQUENCE   644 AA;  70429 MW;  1271072E3447B962 CRC64;
     MADQKKPLQG GATLPLMAMA ALGVVFGDIG TSPLYTLSAC LSAMSLQPTA VNLQGILSLI
     FWTLVLVVSV KYAWVIMRAS NQGEGGAMAL TALASHATGH SNRLRWWILS IGLLGAALFY
     GDGVITPAIS VLSAIEGMEV ASPAWKPLVI PLALGVIIGL FMVQRRGTAA ISHLFGPSML
     VWFLLLFGSG LTWIVADPQV LIALNPWYAL QFFGIHGIGG LVILGAVVLA VTGAEALYAD
     MGHFGARPIR MAWYFLVLPA LALNYLGQGA LLELDPSAIQ NPFFMLFPAW ATIPMVVISG
     IATVIASQSV ISGAYSATRQ ALLLGYLPRQ AIIHTSASER GQIYLPLLNW LLMVAVIVVI
     LWFRSSNALS FAYGTAVTGT MLMTTILVFF VARHSWKWSL WKAGLFCGFF VLLDGVFFGA
     NLLKFVEGGW FPLAIGLAVF TTMSTWRWGR GILASKLYPD TLSVEDFLSS VTPGDPIRVP
     GTAVYLTMRE KAIPHALLHN LKHNKVLHER VVILTIKFEE EPRVLPANRV VVLDYGQGVR
     RLTARYGFME HPDIPEILKS AENSDNLWNP LDTTYFVSRQ RVIPTAKASL SLWREHLFAI
     MLRISANATD FFRLPPNLVM ELGDVVEFSH KVPDAPKKEK TTQQ