ID   KUP_BRUMB               Reviewed;         651 AA.
AC   C0RE23;
DT   28-JUL-2009, integrated into UniProtKB/Swiss-Prot.
DT   05-MAY-2009, sequence version 1.
DT   03-AUG-2022, entry version 54.
DE   RecName: Full=Probable potassium transport system protein kup {ECO:0000255|HAMAP-Rule:MF_01522};
GN   Name=kup {ECO:0000255|HAMAP-Rule:MF_01522}; OrderedLocusNames=BMEA_A1430;
OS   Brucella melitensis biotype 2 (strain ATCC 23457).
OC   Bacteria; Proteobacteria; Alphaproteobacteria; Hyphomicrobiales;
OC   Brucellaceae; Brucella/Ochrobactrum group; Brucella.
OX   NCBI_TaxID=546272;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 23457;
RA   Setubal J.C., Boyle S., Crasta O.R., Gillespie J.J., Kenyon R.W., Lu J.,
RA   Mane S., Nagrani S., Shallom J.M., Shallom S., Shukla M., Snyder E.E.,
RA   Sobral B.W., Wattam A.R., Will R., Williams K., Yoo H., Munk C., Tapia R.,
RA   Han C., Detter J.C., Bruce D., Brettin T.S.;
RT   "Brucella melitensis ATCC 23457 whole genome shotgun sequencing project.";
RL   Submitted (MAR-2009) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Transport of potassium into the cell. {ECO:0000255|HAMAP-
CC       Rule:MF_01522}.
CC   -!- SUBCELLULAR LOCATION: Cell inner membrane {ECO:0000255|HAMAP-
CC       Rule:MF_01522}; Multi-pass membrane protein {ECO:0000255|HAMAP-
CC       Rule:MF_01522}.
CC   -!- SIMILARITY: Belongs to the HAK/KUP transporter (TC 2.A.72) family.
CC       {ECO:0000255|HAMAP-Rule:MF_01522}.
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DR   EMBL; CP001488; ACO01145.1; -; Genomic_DNA.
DR   RefSeq; WP_004686379.1; NC_012441.1.
DR   AlphaFoldDB; C0RE23; -.
DR   EnsemblBacteria; ACO01145; ACO01145; BMEA_A1430.
DR   KEGG; bmi:BMEA_A1430; -.
DR   HOGENOM; CLU_008142_4_2_5; -.
DR   OMA; AIRVSWL; -.
DR   Proteomes; UP000001748; Chromosome I.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0015079; F:potassium ion transmembrane transporter activity; IEA:UniProtKB-UniRule.
DR   HAMAP; MF_01522; Kup; 1.
DR   InterPro; IPR003855; K+_transporter.
DR   InterPro; IPR023051; K+_uptake_low_affin.
DR   PANTHER; PTHR30540; PTHR30540; 1.
DR   Pfam; PF02705; K_trans; 1.
PE   3: Inferred from homology;
KW   Cell inner membrane; Cell membrane; Ion transport; Membrane; Potassium;
KW   Potassium transport; Transmembrane; Transmembrane helix; Transport.
FT   CHAIN           1..651
FT                   /note="Probable potassium transport system protein kup"
FT                   /id="PRO_1000185113"
FT   TRANSMEM        41..61
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01522"
FT   TRANSMEM        82..102
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01522"
FT   TRANSMEM        130..150
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01522"
FT   TRANSMEM        163..183
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01522"
FT   TRANSMEM        194..214
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01522"
FT   TRANSMEM        235..255
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01522"
FT   TRANSMEM        276..296
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01522"
FT   TRANSMEM        309..329
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01522"
FT   TRANSMEM        366..386
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01522"
FT   TRANSMEM        395..415
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01522"
FT   TRANSMEM        426..446
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01522"
FT   TRANSMEM        450..470
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01522"
SQ   SEQUENCE   651 AA;  70461 MW;  0AB6F52F93F4A6E1 CRC64;
     MSGELNGNDT SAQAAVSAGS VLEGAAFADE GEQHNESMKT LVLGALGVVY GDIGTSPIYA
     FREALHAAAT NGILARSDIL GVVSLIFWAL TLVVTVKYVL FVLRADNNGE GGILSLMALV
     RGALKGRPDL ILGVGICGAA LFFGDAVITP AISVLSAMEG LEIVAPNLTP FVVPATVVIL
     VTLFSVQKLG TGRVAIVFGP IMALWFVALG ASGLWHIFDD PTVMAALNPY YAVRFLTVSP
     AVAFVTVGAV FLAMTGAEAL YADLGHFGRK PIVRAWLWIV FPCLLLNYFG QAAFILSHGE
     AAALPFFQMI PSFALWPMVL LATAATVIAS QAVITGAYSV ARQAVQLNIL SRLEIQHTSE
     KLHGQIYIPR VNLLLGLAVV ILVLGFEKSS NLAAAYGIAV TGNMLVTTVL LYIVMTRIWN
     WRVSRALPII LGFLVIDMLF FSANIIKVHE GGWASIGIAT VLVLIMWTWV RGTRHLFQKT
     RKAEVPLDLI VEQMAKRPPT IVPGTAVFLT GDPKSAPTAL MHSLKHYKVL HENNVILTVV
     TASKPWVASA DRARVSQYNE RFMLVTLTFG YMQQPNIPRA LGLCRRLGWK FDIMTTSFFL
     SRRSLKASVH SGMPLWQDKL FILLARTASD ATEYFQIPTG RVVEIGTQVN I