ID   KUP_BURPS               Reviewed;         630 AA.
AC   Q63US0;
DT   07-DEC-2004, integrated into UniProtKB/Swiss-Prot.
DT   25-OCT-2004, sequence version 1.
DT   03-AUG-2022, entry version 76.
DE   RecName: Full=Probable potassium transport system protein kup {ECO:0000255|HAMAP-Rule:MF_01522};
GN   Name=kup {ECO:0000255|HAMAP-Rule:MF_01522}; Synonyms=trkD;
GN   OrderedLocusNames=BPSL1526;
OS   Burkholderia pseudomallei (strain K96243).
OC   Bacteria; Proteobacteria; Betaproteobacteria; Burkholderiales;
OC   Burkholderiaceae; Burkholderia; pseudomallei group.
OX   NCBI_TaxID=272560;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=K96243;
RX   PubMed=15377794; DOI=10.1073/pnas.0403302101;
RA   Holden M.T.G., Titball R.W., Peacock S.J., Cerdeno-Tarraga A.-M.,
RA   Atkins T., Crossman L.C., Pitt T., Churcher C., Mungall K.L., Bentley S.D.,
RA   Sebaihia M., Thomson N.R., Bason N., Beacham I.R., Brooks K., Brown K.A.,
RA   Brown N.F., Challis G.L., Cherevach I., Chillingworth T., Cronin A.,
RA   Crossett B., Davis P., DeShazer D., Feltwell T., Fraser A., Hance Z.,
RA   Hauser H., Holroyd S., Jagels K., Keith K.E., Maddison M., Moule S.,
RA   Price C., Quail M.A., Rabbinowitsch E., Rutherford K., Sanders M.,
RA   Simmonds M., Songsivilai S., Stevens K., Tumapa S., Vesaratchavest M.,
RA   Whitehead S., Yeats C., Barrell B.G., Oyston P.C.F., Parkhill J.;
RT   "Genomic plasticity of the causative agent of melioidosis, Burkholderia
RT   pseudomallei.";
RL   Proc. Natl. Acad. Sci. U.S.A. 101:14240-14245(2004).
CC   -!- FUNCTION: Transport of potassium into the cell. {ECO:0000255|HAMAP-
CC       Rule:MF_01522}.
CC   -!- SUBCELLULAR LOCATION: Cell inner membrane {ECO:0000255|HAMAP-
CC       Rule:MF_01522}; Multi-pass membrane protein {ECO:0000255|HAMAP-
CC       Rule:MF_01522}.
CC   -!- SIMILARITY: Belongs to the HAK/KUP transporter (TC 2.A.72) family.
CC       {ECO:0000255|HAMAP-Rule:MF_01522}.
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DR   EMBL; BX571965; CAH35527.1; -; Genomic_DNA.
DR   RefSeq; WP_004550348.1; NZ_CP009538.1.
DR   RefSeq; YP_108146.1; NC_006350.1.
DR   AlphaFoldDB; Q63US0; -.
DR   STRING; 272560.BPSL1526; -.
DR   EnsemblBacteria; CAH35527; CAH35527; BPSL1526.
DR   KEGG; bps:BPSL1526; -.
DR   PATRIC; fig|272560.51.peg.3565; -.
DR   eggNOG; COG3158; Bacteria.
DR   OMA; AADQFEI; -.
DR   Proteomes; UP000000605; Chromosome 1.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0015079; F:potassium ion transmembrane transporter activity; IEA:UniProtKB-UniRule.
DR   HAMAP; MF_01522; Kup; 1.
DR   InterPro; IPR003855; K+_transporter.
DR   InterPro; IPR023051; K+_uptake_low_affin.
DR   PANTHER; PTHR30540; PTHR30540; 1.
DR   Pfam; PF02705; K_trans; 1.
PE   3: Inferred from homology;
KW   Cell inner membrane; Cell membrane; Ion transport; Membrane; Potassium;
KW   Potassium transport; Reference proteome; Transmembrane;
KW   Transmembrane helix; Transport.
FT   CHAIN           1..630
FT                   /note="Probable potassium transport system protein kup"
FT                   /id="PRO_0000209005"
FT   TRANSMEM        17..37
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01522"
FT   TRANSMEM        51..71
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01522"
FT   TRANSMEM        105..125
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01522"
FT   TRANSMEM        144..164
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01522"
FT   TRANSMEM        175..195
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01522"
FT   TRANSMEM        218..238
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01522"
FT   TRANSMEM        255..275
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01522"
FT   TRANSMEM        344..364
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01522"
FT   TRANSMEM        374..394
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01522"
FT   TRANSMEM        402..422
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01522"
FT   TRANSMEM        428..448
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01522"
SQ   SEQUENCE   630 AA;  68661 MW;  FC4A45EE22416931 CRC64;
     MTDTNHSSMR QHSLQSLAIA AIGVVFGDIG TSPLYSLKEA FSPAHGIPLT PSAILGVISL
     LFWAIILVVG IKYVLFVMRA DNNGEGGVLA LMALSLRPLN PKSRITGLMM ALGIFGACMF
     YGDAVITPAI SVMSAVEGLE VATPQLSHLV LPITIVILIA LFWIQRHGTA TVGKLFGPIM
     VLWFVTIAVL GIYHIARAPM IVSAINPYYA FSFMSEHVLL AYVVLGSVVL VLTGAEALYA
     DMGHFGAKPI RLAAYVLVMP SLVLNYFGQG ALLLLDPKAI ENPFFLLAPQ WAALPLVVLS
     TVATVIASQA VISGAYSLTS QAIQLGYVPR MKILHTSELA IGQIYVPVVN WLLLFVILCI
     VIGFKSSDNL AAAYGIAVTA TMVITTILAA VVMVKVWNWN KLLVAMIIGV FLVIDLGFFG
     ANLLKVEQGG WLPLGIGALL FFLLMTWYKG RHIVKERTAA DGIPLAPFLQ GLLAHPPHRV
     SGTAIYLTGN DTLVPVSLLH NLKHNKVLHE RTIFMTFVTR DIPYVKDHER VTVHDAGEGL
     YIVKAEYGFN ETPDVKAVLE EVARQRGMTF ELMDTSFFLA RETVVPTHLP GMSIWRERVF
     AWMHQNAAKP TDFFAIPANR VVELGTKIEI