ID   KUP_CLOPS               Reviewed;         657 AA.
AC   Q0SU39;
DT   06-MAR-2007, integrated into UniProtKB/Swiss-Prot.
DT   05-SEP-2006, sequence version 1.
DT   25-MAY-2022, entry version 74.
DE   RecName: Full=Probable potassium transport system protein kup {ECO:0000255|HAMAP-Rule:MF_01522};
GN   Name=kup {ECO:0000255|HAMAP-Rule:MF_01522}; OrderedLocusNames=CPR_1046;
OS   Clostridium perfringens (strain SM101 / Type A).
OC   Bacteria; Firmicutes; Clostridia; Eubacteriales; Clostridiaceae;
OC   Clostridium.
OX   NCBI_TaxID=289380;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=SM101 / Type A;
RX   PubMed=16825665; DOI=10.1101/gr.5238106;
RA   Myers G.S.A., Rasko D.A., Cheung J.K., Ravel J., Seshadri R., DeBoy R.T.,
RA   Ren Q., Varga J., Awad M.M., Brinkac L.M., Daugherty S.C., Haft D.H.,
RA   Dodson R.J., Madupu R., Nelson W.C., Rosovitz M.J., Sullivan S.A.,
RA   Khouri H., Dimitrov G.I., Watkins K.L., Mulligan S., Benton J., Radune D.,
RA   Fisher D.J., Atkins H.S., Hiscox T., Jost B.H., Billington S.J.,
RA   Songer J.G., McClane B.A., Titball R.W., Rood J.I., Melville S.B.,
RA   Paulsen I.T.;
RT   "Skewed genomic variability in strains of the toxigenic bacterial pathogen,
RT   Clostridium perfringens.";
RL   Genome Res. 16:1031-1040(2006).
CC   -!- FUNCTION: Transport of potassium into the cell. {ECO:0000255|HAMAP-
CC       Rule:MF_01522}.
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000255|HAMAP-Rule:MF_01522};
CC       Multi-pass membrane protein {ECO:0000255|HAMAP-Rule:MF_01522}.
CC   -!- SIMILARITY: Belongs to the HAK/KUP transporter (TC 2.A.72) family.
CC       {ECO:0000255|HAMAP-Rule:MF_01522}.
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DR   EMBL; CP000312; ABG87155.1; -; Genomic_DNA.
DR   AlphaFoldDB; Q0SU39; -.
DR   EnsemblBacteria; ABG87155; ABG87155; CPR_1046.
DR   KEGG; cpr:CPR_1046; -.
DR   OMA; AADQFEI; -.
DR   Proteomes; UP000001824; Chromosome.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0015079; F:potassium ion transmembrane transporter activity; IEA:UniProtKB-UniRule.
DR   HAMAP; MF_01522; Kup; 1.
DR   InterPro; IPR003855; K+_transporter.
DR   InterPro; IPR023051; K+_uptake_low_affin.
DR   PANTHER; PTHR30540; PTHR30540; 1.
DR   Pfam; PF02705; K_trans; 1.
PE   3: Inferred from homology;
KW   Cell membrane; Ion transport; Membrane; Potassium; Potassium transport;
KW   Transmembrane; Transmembrane helix; Transport.
FT   CHAIN           1..657
FT                   /note="Probable potassium transport system protein kup"
FT                   /id="PRO_0000279779"
FT   TRANSMEM        15..35
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01522"
FT   TRANSMEM        48..68
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01522"
FT   TRANSMEM        100..120
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01522"
FT   TRANSMEM        147..167
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01522"
FT   TRANSMEM        173..193
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01522"
FT   TRANSMEM        219..239
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01522"
FT   TRANSMEM        251..271
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01522"
FT   TRANSMEM        292..312
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01522"
FT   TRANSMEM        348..368
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01522"
FT   TRANSMEM        378..398
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01522"
FT   TRANSMEM        403..423
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01522"
FT   TRANSMEM        431..451
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01522"
SQ   SEQUENCE   657 AA;  73956 MW;  38FAE32D27CC9041 CRC64;
     MSTNKSSIEK ITLGSFLIAL GVVYGDIGTS PLYVMKSIIN GNGGLESITP DFILGVLSLI
     FWTMTLLTTI KYVLITLKAD NKGEGGIFSL YTLIRRRAKW LIIPAMVGGS ALLADGMLTP
     AVTVTSSIEG LKILPSFNDI FGNNQDIIII IVLVILSFLF FIQHFGTEII GKIFGPVMFI
     WFAFLAILGI VNLSGNLYLL KALSPHYAIK ILFSPNNHLG FFILGGVFLS TTGAEALYSD
     LGHVGRKNIY LTWPLVKICL LLNYFGQAAW ILSQKNNAKL YGIESLNPFF QMMPSWLLLF
     GVLISTLAAI IASQALISGS YTLVSEAIKL NLFPRLQCLY PSNSKGQIYM PAINRILWIA
     CIAIVLYFRS SDNMEAAYGL SITVTMLMTS ILLFNYLLKR KTPLPIALII LVFFSSLEFS
     FLISSAVKFE KGGFVSVLIA LCILSIMYIW IKGHYIKMSL LDYIPIENYK NQLKELKNDV
     DRPKYATNLV YLTSSEKSKR IERKIMYSIL DKRPKRADVY WFVNVIVTDE PYTSEYTVNT
     FGTDYMVKVQ LKLGFRVNQK LNVFLRQIVC ELINNGDIKV QNKKYTTLHN RNVGDFRFIL
     INECLSSESK LESWNSIIIR SKLFIKKFTV SPAKWFGLES SEIEVENVPL ILGSTRM