ID   KUP_CORGL               Reviewed;         624 AA.
AC   Q8NSG3; Q6M767;
DT   27-SEP-2004, integrated into UniProtKB/Swiss-Prot.
DT   01-OCT-2002, sequence version 1.
DT   03-AUG-2022, entry version 94.
DE   RecName: Full=Probable potassium transport system protein kup {ECO:0000255|HAMAP-Rule:MF_01522};
GN   Name=kup {ECO:0000255|HAMAP-Rule:MF_01522};
GN   OrderedLocusNames=Cgl0712, cg0817;
OS   Corynebacterium glutamicum (strain ATCC 13032 / DSM 20300 / BCRC 11384 /
OS   JCM 1318 / LMG 3730 / NCIMB 10025).
OC   Bacteria; Actinobacteria; Corynebacteriales; Corynebacteriaceae;
OC   Corynebacterium.
OX   NCBI_TaxID=196627;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 13032 / DSM 20300 / BCRC 11384 / JCM 1318 / LMG 3730 / NCIMB
RC   10025;
RX   PubMed=12743753; DOI=10.1007/s00253-003-1328-1;
RA   Ikeda M., Nakagawa S.;
RT   "The Corynebacterium glutamicum genome: features and impacts on
RT   biotechnological processes.";
RL   Appl. Microbiol. Biotechnol. 62:99-109(2003).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 13032 / DSM 20300 / BCRC 11384 / JCM 1318 / LMG 3730 / NCIMB
RC   10025;
RX   PubMed=12948626; DOI=10.1016/s0168-1656(03)00154-8;
RA   Kalinowski J., Bathe B., Bartels D., Bischoff N., Bott M., Burkovski A.,
RA   Dusch N., Eggeling L., Eikmanns B.J., Gaigalat L., Goesmann A.,
RA   Hartmann M., Huthmacher K., Kraemer R., Linke B., McHardy A.C., Meyer F.,
RA   Moeckel B., Pfefferle W., Puehler A., Rey D.A., Rueckert C., Rupp O.,
RA   Sahm H., Wendisch V.F., Wiegraebe I., Tauch A.;
RT   "The complete Corynebacterium glutamicum ATCC 13032 genome sequence and its
RT   impact on the production of L-aspartate-derived amino acids and vitamins.";
RL   J. Biotechnol. 104:5-25(2003).
CC   -!- FUNCTION: Transport of potassium into the cell. {ECO:0000255|HAMAP-
CC       Rule:MF_01522}.
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000255|HAMAP-Rule:MF_01522};
CC       Multi-pass membrane protein {ECO:0000255|HAMAP-Rule:MF_01522}.
CC   -!- SIMILARITY: Belongs to the HAK/KUP transporter (TC 2.A.72) family.
CC       {ECO:0000255|HAMAP-Rule:MF_01522}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=CAF19417.1; Type=Erroneous initiation; Evidence={ECO:0000305};
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DR   EMBL; BA000036; BAB98105.1; -; Genomic_DNA.
DR   EMBL; BX927150; CAF19417.1; ALT_INIT; Genomic_DNA.
DR   RefSeq; NP_599944.1; NC_003450.3.
DR   AlphaFoldDB; Q8NSG3; -.
DR   STRING; 196627.cg0817; -.
DR   KEGG; cgb:cg0817; -.
DR   KEGG; cgl:Cgl0712; -.
DR   PATRIC; fig|196627.13.peg.699; -.
DR   eggNOG; COG3158; Bacteria.
DR   HOGENOM; CLU_008142_4_2_11; -.
DR   OMA; AADQFEI; -.
DR   Proteomes; UP000000582; Chromosome.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0015079; F:potassium ion transmembrane transporter activity; IEA:UniProtKB-UniRule.
DR   HAMAP; MF_01522; Kup; 1.
DR   InterPro; IPR003855; K+_transporter.
DR   InterPro; IPR023051; K+_uptake_low_affin.
DR   PANTHER; PTHR30540; PTHR30540; 1.
DR   Pfam; PF02705; K_trans; 1.
PE   3: Inferred from homology;
KW   Cell membrane; Ion transport; Membrane; Potassium; Potassium transport;
KW   Reference proteome; Transmembrane; Transmembrane helix; Transport.
FT   CHAIN           1..624
FT                   /note="Probable potassium transport system protein kup"
FT                   /id="PRO_0000209010"
FT   TRANSMEM        16..36
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01522"
FT   TRANSMEM        59..79
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01522"
FT   TRANSMEM        106..126
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01522"
FT   TRANSMEM        147..167
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01522"
FT   TRANSMEM        174..194
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01522"
FT   TRANSMEM        211..231
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01522"
FT   TRANSMEM        252..272
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01522"
FT   TRANSMEM        292..312
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01522"
FT   TRANSMEM        342..362
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01522"
FT   TRANSMEM        371..391
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01522"
FT   TRANSMEM        394..414
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01522"
FT   TRANSMEM        418..438
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01522"
SQ   SEQUENCE   624 AA;  68626 MW;  66C3C0E8B612D886 CRC64;
     MKSARPKSVA PKSGQALLTL GALGVVFGDI GTSPLYSLHT AFSMQHNKVE VTQENVYGII
     SMVLWTITLI VTVKYVMLVT RADNQGQGGI LALVALLKNR GHWGKFVAVA GMLGAALFYG
     DVVITPAISV LSATEGLTVI SPSFERFILP VSLAVLIAIF AIQPLGTEKV GKAFGPIMLL
     WFVTLAGLGI PQIIGHPEIL QSLSPHWALR LIVAEPFQAF VLLGAVVLTV TGAEALYADM
     GHFGARPIRV AWFCVVMPAL ILTYLGQGAL VINQPEAVRN PMFYLAPEGL RIPLVILATI
     ATVIASQAVI SGAYSLTKQA VNLKLLPRMV IRHTSRKEEG QIYMPLVNGL LFVSVMVVVL
     VFRSSESLAS AYGLAVTGTL VLVSVLYLIY VHTTWWKTAL FIVLIGIPEV LLFASNTTKI
     HDGGWLPLLI AAVLIVVMRT WEWGSDRVNQ ERAELELPMD KFLEKLDQPH NIGLRKVAEV
     AVFPHGTSDT VPLSLVRCVK DLKLLYREIV IVRIVQEHVP HVPPEERAEM EVLHHAPIRV
     VRVDLHLGYF DEQNLPEHLH AIDPTWDNAT YFLSALTLRS RLPGKIAGWR DRLYLSMERN
     QASRTESFKL QPSKTITVGT ELHL