ID   KUP_CUPMC               Reviewed;         632 AA.
AC   Q1LP09;
DT   06-MAR-2007, integrated into UniProtKB/Swiss-Prot.
DT   06-MAR-2007, sequence version 2.
DT   25-MAY-2022, entry version 78.
DE   RecName: Full=Probable potassium transport system protein kup {ECO:0000255|HAMAP-Rule:MF_01522};
GN   Name=kup {ECO:0000255|HAMAP-Rule:MF_01522}; OrderedLocusNames=Rmet_1231;
OS   Cupriavidus metallidurans (strain ATCC 43123 / DSM 2839 / NBRC 102507 /
OS   CH34) (Ralstonia metallidurans).
OC   Bacteria; Proteobacteria; Betaproteobacteria; Burkholderiales;
OC   Burkholderiaceae; Cupriavidus.
OX   NCBI_TaxID=266264;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 43123 / DSM 2839 / NBRC 102507 / CH34;
RX   PubMed=20463976; DOI=10.1371/journal.pone.0010433;
RA   Janssen P.J., Van Houdt R., Moors H., Monsieurs P., Morin N., Michaux A.,
RA   Benotmane M.A., Leys N., Vallaeys T., Lapidus A., Monchy S., Medigue C.,
RA   Taghavi S., McCorkle S., Dunn J., van der Lelie D., Mergeay M.;
RT   "The complete genome sequence of Cupriavidus metallidurans strain CH34, a
RT   master survivalist in harsh and anthropogenic environments.";
RL   PLoS ONE 5:E10433-E10433(2010).
CC   -!- FUNCTION: Transport of potassium into the cell. {ECO:0000255|HAMAP-
CC       Rule:MF_01522}.
CC   -!- SUBCELLULAR LOCATION: Cell inner membrane {ECO:0000255|HAMAP-
CC       Rule:MF_01522}; Multi-pass membrane protein {ECO:0000255|HAMAP-
CC       Rule:MF_01522}.
CC   -!- SIMILARITY: Belongs to the HAK/KUP transporter (TC 2.A.72) family.
CC       {ECO:0000255|HAMAP-Rule:MF_01522}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=ABF08117.1; Type=Erroneous initiation; Evidence={ECO:0000305};
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DR   EMBL; CP000352; ABF08117.1; ALT_INIT; Genomic_DNA.
DR   RefSeq; WP_008646843.1; NC_007973.1.
DR   AlphaFoldDB; Q1LP09; -.
DR   STRING; 266264.Rmet_1231; -.
DR   EnsemblBacteria; ABF08117; ABF08117; Rmet_1231.
DR   GeneID; 60822103; -.
DR   KEGG; rme:Rmet_1231; -.
DR   eggNOG; COG3158; Bacteria.
DR   HOGENOM; CLU_008142_4_2_4; -.
DR   OrthoDB; 589903at2; -.
DR   Proteomes; UP000002429; Chromosome.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0015079; F:potassium ion transmembrane transporter activity; IEA:UniProtKB-UniRule.
DR   HAMAP; MF_01522; Kup; 1.
DR   InterPro; IPR003855; K+_transporter.
DR   InterPro; IPR023051; K+_uptake_low_affin.
DR   PANTHER; PTHR30540; PTHR30540; 1.
DR   Pfam; PF02705; K_trans; 1.
PE   3: Inferred from homology;
KW   Cell inner membrane; Cell membrane; Ion transport; Membrane; Potassium;
KW   Potassium transport; Reference proteome; Transmembrane;
KW   Transmembrane helix; Transport.
FT   CHAIN           1..632
FT                   /note="Probable potassium transport system protein kup"
FT                   /id="PRO_0000279817"
FT   TRANSMEM        19..39
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01522"
FT   TRANSMEM        59..79
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01522"
FT   TRANSMEM        110..130
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01522"
FT   TRANSMEM        146..166
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01522"
FT   TRANSMEM        178..198
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01522"
FT   TRANSMEM        221..241
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01522"
FT   TRANSMEM        256..276
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01522"
FT   TRANSMEM        298..318
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01522"
FT   TRANSMEM        346..366
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01522"
FT   TRANSMEM        375..395
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01522"
FT   TRANSMEM        403..423
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01522"
FT   TRANSMEM        428..448
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01522"
SQ   SEQUENCE   632 AA;  69116 MW;  DB87045B24293230 CRC64;
     MTQSTTSHYY VESPSSRALV VGAIGVVFGD IGTSPLYSLK ECFSPEHGIP FSPDAVLGII
     SMLFWAFVIV VSLKYVMFVM RADNNGEGGI LALMALALRT AAPRSRMAKL IMMFGIFGAC
     MFYGDAVITP AISVLSAVEG LEIAAPGLSH FVIPITLLIL ALLFFIQRSG THVVGKLFGP
     IMVVWFLALG ALGLIHLVQA PGIVKAINPV YAVSFLHDHS LQAFIVLGSV FLVLTGAEAL
     YADMGHFGAK PIRTAWFVLV MPCLILNYFG QGAMLLGNPD AIENPFYLMV PSALQLPMVL
     LATAATVIAS QAVISGAFSL TSQAIQLGFM PRMRIRYTSA AEIGQIYMPV INWILLVLVI
     CVVLAFKKSD NLAAAYGIAV TTTMVITTFL AALVMRNVWK WNPALVTLIS LTFLVVDMSF
     FAANLLKIAE GGWFPLLMGG SAFFLLMTWH SGRKLLRARS LEDGIPLEPF IAGLLAHPPH
     RVEGTAVFLT GNTESVPVSL LHNLKHNRVL HERVVFLQFV TRDIPYVDDD ERLSCKDLGG
     GVYILKSEYG FKETPDVQRV LDLAQRKLGM QFELMETSFF IARESVIPSK LPGMSMWRES
     LFAWMHQNGA KPSDFFSIPA NRVVELGTKV EI