ID   KUP_ENTFA               Reviewed;         668 AA.
AC   Q837G9;
DT   27-SEP-2004, integrated into UniProtKB/Swiss-Prot.
DT   01-JUN-2003, sequence version 1.
DT   03-AUG-2022, entry version 91.
DE   RecName: Full=Probable potassium transport system protein kup {ECO:0000255|HAMAP-Rule:MF_01522};
GN   Name=kup {ECO:0000255|HAMAP-Rule:MF_01522}; OrderedLocusNames=EF_0872;
OS   Enterococcus faecalis (strain ATCC 700802 / V583).
OC   Bacteria; Firmicutes; Bacilli; Lactobacillales; Enterococcaceae;
OC   Enterococcus.
OX   NCBI_TaxID=226185;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 700802 / V583;
RX   PubMed=12663927; DOI=10.1126/science.1080613;
RA   Paulsen I.T., Banerjei L., Myers G.S.A., Nelson K.E., Seshadri R.,
RA   Read T.D., Fouts D.E., Eisen J.A., Gill S.R., Heidelberg J.F., Tettelin H.,
RA   Dodson R.J., Umayam L.A., Brinkac L.M., Beanan M.J., Daugherty S.C.,
RA   DeBoy R.T., Durkin S.A., Kolonay J.F., Madupu R., Nelson W.C.,
RA   Vamathevan J.J., Tran B., Upton J., Hansen T., Shetty J., Khouri H.M.,
RA   Utterback T.R., Radune D., Ketchum K.A., Dougherty B.A., Fraser C.M.;
RT   "Role of mobile DNA in the evolution of vancomycin-resistant Enterococcus
RT   faecalis.";
RL   Science 299:2071-2074(2003).
CC   -!- FUNCTION: Transport of potassium into the cell. {ECO:0000255|HAMAP-
CC       Rule:MF_01522}.
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000255|HAMAP-Rule:MF_01522};
CC       Multi-pass membrane protein {ECO:0000255|HAMAP-Rule:MF_01522}.
CC   -!- SIMILARITY: Belongs to the HAK/KUP transporter (TC 2.A.72) family.
CC       {ECO:0000255|HAMAP-Rule:MF_01522}.
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DR   EMBL; AE016830; AAO80682.1; -; Genomic_DNA.
DR   RefSeq; NP_814612.1; NC_004668.1.
DR   RefSeq; WP_002387003.1; NZ_KE136527.1.
DR   AlphaFoldDB; Q837G9; -.
DR   STRING; 226185.EF_0872; -.
DR   EnsemblBacteria; AAO80682; AAO80682; EF_0872.
DR   KEGG; efa:EF0872; -.
DR   PATRIC; fig|226185.45.peg.3082; -.
DR   eggNOG; COG3158; Bacteria.
DR   HOGENOM; CLU_008142_4_1_9; -.
DR   OMA; AADQFEI; -.
DR   Proteomes; UP000001415; Chromosome.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0015079; F:potassium ion transmembrane transporter activity; IEA:UniProtKB-UniRule.
DR   HAMAP; MF_01522; Kup; 1.
DR   InterPro; IPR003855; K+_transporter.
DR   InterPro; IPR023051; K+_uptake_low_affin.
DR   PANTHER; PTHR30540; PTHR30540; 1.
DR   Pfam; PF02705; K_trans; 1.
PE   3: Inferred from homology;
KW   Cell membrane; Ion transport; Membrane; Potassium; Potassium transport;
KW   Reference proteome; Transmembrane; Transmembrane helix; Transport.
FT   CHAIN           1..668
FT                   /note="Probable potassium transport system protein kup"
FT                   /id="PRO_0000209014"
FT   TRANSMEM        17..37
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01522"
FT   TRANSMEM        59..79
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01522"
FT   TRANSMEM        104..124
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01522"
FT   TRANSMEM        148..168
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01522"
FT   TRANSMEM        175..195
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01522"
FT   TRANSMEM        221..241
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01522"
FT   TRANSMEM        256..276
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01522"
FT   TRANSMEM        299..319
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01522"
FT   TRANSMEM        350..370
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01522"
FT   TRANSMEM        380..400
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01522"
FT   TRANSMEM        403..423
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01522"
FT   TRANSMEM        430..450
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01522"
SQ   SEQUENCE   668 AA;  74712 MW;  484E98C626227475 CRC64;
     MLHKAEGFDR RKFTMAGILV AMGVVYGDIG TSPLYVMKAI VGDNGGLARV SESFILGSVS
     LIFWTLTILT TIKYVVIALN ADNHGEGGIF SLYTLVRKKS KYLIIPAMIG GAALLADGVL
     TPAVTVTTAI EGLRGIPAFF ERFGNDQTII VVITLTIILI LFSVQRFGTE LVGKAFGPIM
     FLWFTFLGII GLMNFSQDWT VIRALNPYYA LQLLVSPENK LGLFILGNIF LATTGAEALY
     SDLGHVGKMN IRISWPYIKI CLILNYLGQA AWLLTVKENP EMQALAEINP FFQMIPRGIL
     VFGVVFATIA AVIASQALIS GSYTLVSEAI KLKLLPRLKI IYPGSNIGQM YIPAVNLILW
     LACSAIVLAF RTSTHMEAAY GLSITITMLM TTILLLFYLL DKIPAWSAYL ISLFFAAIEV
     VFFFSSAAKF FHGGYVAVGM AVFLLCIMII WERGNEIKEA TAEQVSLKKY VPQLKALKED
     TSVPMYQTNV VFLTSDRVDG EINRNIIYSI LDKQPKRANV YWFVNVQVTD EPFTQEYSVD
     MLGTDFIVQV QLYLGFHISQ EVNVYLRQIV HDLMKTGRLP KQPQRYSLTP GREVGDFQFV
     LIQEELSNVS ELKKWDRQIM QAKLAIKNLT TSPESWFGLE YSEVKYESVP LIIGPQRKTH
     LVERKNRS