ID   KUP_LACCB               Reviewed;         684 AA.
AC   B3WA65;
DT   14-APR-2009, integrated into UniProtKB/Swiss-Prot.
DT   02-SEP-2008, sequence version 1.
DT   25-MAY-2022, entry version 64.
DE   RecName: Full=Probable potassium transport system protein kup {ECO:0000255|HAMAP-Rule:MF_01522};
GN   Name=kup {ECO:0000255|HAMAP-Rule:MF_01522}; OrderedLocusNames=LCABL_25180;
OS   Lacticaseibacillus casei (strain BL23) (Lactobacillus casei).
OC   Bacteria; Firmicutes; Bacilli; Lactobacillales; Lactobacillaceae;
OC   Lacticaseibacillus.
OX   NCBI_TaxID=543734;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=BL23;
RA   Maze A., Boel G., Bourand A., Loux V., Gibrat J.F., Zuniga M., Hartke A.,
RA   Deutscher J.;
RT   "Lactobacillus casei BL23 complete genome sequence.";
RL   Submitted (JUN-2008) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Transport of potassium into the cell. {ECO:0000255|HAMAP-
CC       Rule:MF_01522}.
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000255|HAMAP-Rule:MF_01522};
CC       Multi-pass membrane protein {ECO:0000255|HAMAP-Rule:MF_01522}.
CC   -!- SIMILARITY: Belongs to the HAK/KUP transporter (TC 2.A.72) family.
CC       {ECO:0000255|HAMAP-Rule:MF_01522}.
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DR   EMBL; FM177140; CAQ67584.1; -; Genomic_DNA.
DR   RefSeq; WP_003567271.1; NC_010999.1.
DR   AlphaFoldDB; B3WA65; -.
DR   KEGG; lcb:LCABL_25180; -.
DR   HOGENOM; CLU_008142_4_1_9; -.
DR   OMA; AADQFEI; -.
DR   OrthoDB; 589903at2; -.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0015079; F:potassium ion transmembrane transporter activity; IEA:UniProtKB-UniRule.
DR   HAMAP; MF_01522; Kup; 1.
DR   InterPro; IPR003855; K+_transporter.
DR   InterPro; IPR023051; K+_uptake_low_affin.
DR   PANTHER; PTHR30540; PTHR30540; 1.
DR   Pfam; PF02705; K_trans; 1.
PE   3: Inferred from homology;
KW   Cell membrane; Ion transport; Membrane; Potassium; Potassium transport;
KW   Transmembrane; Transmembrane helix; Transport.
FT   CHAIN           1..684
FT                   /note="Probable potassium transport system protein kup"
FT                   /id="PRO_1000190273"
FT   TRANSMEM        19..39
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01522"
FT   TRANSMEM        61..81
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01522"
FT   TRANSMEM        104..124
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01522"
FT   TRANSMEM        151..171
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01522"
FT   TRANSMEM        177..197
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01522"
FT   TRANSMEM        223..243
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01522"
FT   TRANSMEM        255..275
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01522"
FT   TRANSMEM        303..323
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01522"
FT   TRANSMEM        352..372
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01522"
FT   TRANSMEM        381..401
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01522"
FT   TRANSMEM        407..427
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01522"
FT   TRANSMEM        433..453
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01522"
SQ   SEQUENCE   684 AA;  76719 MW;  38D179922C357F2D CRC64;
     MASGLTANKK LRHKITAAAL LVTLGVVYGD IGTSPLYVMK SIVAGNGGMG HFDTDFLVGS
     VSLIFWTLLI ITTVKYVLIA LRADNNGEGG IFALYTLVRQ RARWLVLPAM VGGAALLADG
     MLTPAVTVTT AIEGLKGVHI NGNILIDNQQ QVIWVTILII TFLFFIQRFG TDLIGKAFGP
     IMFVWFTFLG VAGFIALSKD WSMLRALNPY YALHLLVSPD NKMGLFILGS IFLATTGAEA
     LYSDMGHVGR GNIYLSWPYV NICLVLNYFG QAVWLDQNSK VTAFNKITDF NPFFQMLPES
     IRLGAIILAT LAAIIASQAL ISGSYTLVSE AIKLRFLPRL HIIYPTRLKG QLYIPVVNTI
     LWLACLAIIG YFKTSAEMEG AYGLAITITM LMTTLLLYQY LRSRHAPAVI AIGTLIFFSA
     IETVFFISSA VKFLHGGYVT AMIAFIILAV MYVWQYGGRI RDDNTYRAEM ASLFAYKNQL
     SELRNDPDYP TYTTNLVYMT QIANDHYIKK EILYSILDKR PKRARVYWFV TVNVTDEPYT
     AEYTTDTYGT DYMVNVQLYL GFRMEQQVNV FLRQIVNDMM REGELPTQPQ KYTTIPDRQV
     GDWTFVLLHE ELSPQTQIKG FQKAIIQARL RLQHIAVSPA QWFGLEYADT IDETVPLVLG
     KIPITKLNRL TRSQAEAQPE DEDD