ID   KUP_LACDB               Reviewed;         676 AA.
AC   Q04CF3;
DT   06-MAR-2007, integrated into UniProtKB/Swiss-Prot.
DT   14-NOV-2006, sequence version 1.
DT   03-AUG-2022, entry version 79.
DE   RecName: Full=Probable potassium transport system protein kup {ECO:0000255|HAMAP-Rule:MF_01522};
GN   Name=kup {ECO:0000255|HAMAP-Rule:MF_01522}; OrderedLocusNames=LBUL_0192;
OS   Lactobacillus delbrueckii subsp. bulgaricus (strain ATCC BAA-365 / Lb-18).
OC   Bacteria; Firmicutes; Bacilli; Lactobacillales; Lactobacillaceae;
OC   Lactobacillus.
OX   NCBI_TaxID=321956;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC BAA-365 / Lb-18;
RX   PubMed=17030793; DOI=10.1073/pnas.0607117103;
RA   Makarova K.S., Slesarev A., Wolf Y.I., Sorokin A., Mirkin B., Koonin E.V.,
RA   Pavlov A., Pavlova N., Karamychev V., Polouchine N., Shakhova V.,
RA   Grigoriev I., Lou Y., Rohksar D., Lucas S., Huang K., Goodstein D.M.,
RA   Hawkins T., Plengvidhya V., Welker D., Hughes J., Goh Y., Benson A.,
RA   Baldwin K., Lee J.-H., Diaz-Muniz I., Dosti B., Smeianov V., Wechter W.,
RA   Barabote R., Lorca G., Altermann E., Barrangou R., Ganesan B., Xie Y.,
RA   Rawsthorne H., Tamir D., Parker C., Breidt F., Broadbent J.R., Hutkins R.,
RA   O'Sullivan D., Steele J., Unlu G., Saier M.H. Jr., Klaenhammer T.,
RA   Richardson P., Kozyavkin S., Weimer B.C., Mills D.A.;
RT   "Comparative genomics of the lactic acid bacteria.";
RL   Proc. Natl. Acad. Sci. U.S.A. 103:15611-15616(2006).
CC   -!- FUNCTION: Transport of potassium into the cell. {ECO:0000255|HAMAP-
CC       Rule:MF_01522}.
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000255|HAMAP-Rule:MF_01522};
CC       Multi-pass membrane protein {ECO:0000255|HAMAP-Rule:MF_01522}.
CC   -!- SIMILARITY: Belongs to the HAK/KUP transporter (TC 2.A.72) family.
CC       {ECO:0000255|HAMAP-Rule:MF_01522}.
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DR   EMBL; CP000412; ABJ57869.1; -; Genomic_DNA.
DR   RefSeq; WP_011677959.1; NC_008529.1.
DR   AlphaFoldDB; Q04CF3; -.
DR   KEGG; lbu:LBUL_0192; -.
DR   HOGENOM; CLU_008142_4_1_9; -.
DR   OMA; TILLYEW; -.
DR   BioCyc; LDEL321956:LBUL_RS00895-MON; -.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0015079; F:potassium ion transmembrane transporter activity; IEA:UniProtKB-UniRule.
DR   HAMAP; MF_01522; Kup; 1.
DR   InterPro; IPR003855; K+_transporter.
DR   InterPro; IPR023051; K+_uptake_low_affin.
DR   PANTHER; PTHR30540; PTHR30540; 1.
DR   Pfam; PF02705; K_trans; 1.
PE   3: Inferred from homology;
KW   Cell membrane; Ion transport; Membrane; Potassium; Potassium transport;
KW   Transmembrane; Transmembrane helix; Transport.
FT   CHAIN           1..676
FT                   /note="Probable potassium transport system protein kup"
FT                   /id="PRO_0000279792"
FT   TRANSMEM        14..34
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01522"
FT   TRANSMEM        56..76
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01522"
FT   TRANSMEM        97..117
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01522"
FT   TRANSMEM        142..162
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01522"
FT   TRANSMEM        173..193
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01522"
FT   TRANSMEM        219..239
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01522"
FT   TRANSMEM        252..272
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01522"
FT   TRANSMEM        296..316
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01522"
FT   TRANSMEM        345..365
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01522"
FT   TRANSMEM        376..396
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01522"
FT   TRANSMEM        402..422
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01522"
FT   TRANSMEM        429..449
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01522"
SQ   SEQUENCE   676 AA;  74761 MW;  B3A2AC14D036E9E6 CRC64;
     MEVENKLNRM TAAGLLIAIG IVYGDIGTSP LYVMKSVIAG NGGINTVGRD LIIGTISLIL
     WTVTLLTTVQ TVIIALRATN HGEGGIFALY ALIRKKAAWL VWPALIGGAA ILADGTLTPA
     VTVTSAIEGL KGLEFGKGNV PVSNQTTVLV ITIVILLVLF SIQRMGTRII GKAFGPIMLV
     WFAFLGVMGL INIGGNWWIL QALNPYYAIK LLFSPYNKAG FAILGSIFLA TTGAEALYSD
     VGHVGKGNII GSWPFVFVCL SLNYFGQGVW ILNNTNMHSA TEINPFYAMI PENIRLASIV
     LATLAAIIAS QALITGSFTL VAESINLKFL PRMNILYPSD ERGQIYIPAV NKMLGITTIA
     LVLFFRTSAH MEAAYGLSIT ISMLTTTILL YEWLVLKQGH NLANLLFVIF FSTINILFMG
     SSLSKFTHGG YVSLLITLLI ASVMVVWYFG NKVRDQNVAG NAYVRLDEYT DMLTNLSHDD
     NYPTYSDNLV YMANVKYNKF IKREILYSIL DKRPKRARAY WFVTVNVTNE PFTAEYAVNT
     FGTKNVINIQ LYLGFKKQTS VNVYLRQIVH DLIKDNTIEA QPQEYTTTPG RDVGDFKFVI
     VNDVISPSTT LSSYKKWLVK ARVQLQNLSL NPAQWFGLEF ADMVIERVPL ILGKQEPERI
     KRVAPVDYSK ASLNKK