ID   KUP_LEVBA               Reviewed;         675 AA.
AC   Q03S07;
DT   06-MAR-2007, integrated into UniProtKB/Swiss-Prot.
DT   14-NOV-2006, sequence version 1.
DT   25-MAY-2022, entry version 81.
DE   RecName: Full=Probable potassium transport system protein kup {ECO:0000255|HAMAP-Rule:MF_01522};
GN   Name=kup {ECO:0000255|HAMAP-Rule:MF_01522}; OrderedLocusNames=LVIS_0875;
OS   Levilactobacillus brevis (strain ATCC 367 / BCRC 12310 / CIP 105137 / JCM
OS   1170 / LMG 11437 / NCIMB 947 / NCTC 947) (Lactobacillus brevis).
OC   Bacteria; Firmicutes; Bacilli; Lactobacillales; Lactobacillaceae;
OC   Levilactobacillus.
OX   NCBI_TaxID=387344;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 367 / BCRC 12310 / CIP 105137 / JCM 1170 / LMG 11437 / NCIMB
RC   947 / NCTC 947;
RX   PubMed=17030793; DOI=10.1073/pnas.0607117103;
RA   Makarova K.S., Slesarev A., Wolf Y.I., Sorokin A., Mirkin B., Koonin E.V.,
RA   Pavlov A., Pavlova N., Karamychev V., Polouchine N., Shakhova V.,
RA   Grigoriev I., Lou Y., Rohksar D., Lucas S., Huang K., Goodstein D.M.,
RA   Hawkins T., Plengvidhya V., Welker D., Hughes J., Goh Y., Benson A.,
RA   Baldwin K., Lee J.-H., Diaz-Muniz I., Dosti B., Smeianov V., Wechter W.,
RA   Barabote R., Lorca G., Altermann E., Barrangou R., Ganesan B., Xie Y.,
RA   Rawsthorne H., Tamir D., Parker C., Breidt F., Broadbent J.R., Hutkins R.,
RA   O'Sullivan D., Steele J., Unlu G., Saier M.H. Jr., Klaenhammer T.,
RA   Richardson P., Kozyavkin S., Weimer B.C., Mills D.A.;
RT   "Comparative genomics of the lactic acid bacteria.";
RL   Proc. Natl. Acad. Sci. U.S.A. 103:15611-15616(2006).
CC   -!- FUNCTION: Transport of potassium into the cell. {ECO:0000255|HAMAP-
CC       Rule:MF_01522}.
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000255|HAMAP-Rule:MF_01522};
CC       Multi-pass membrane protein {ECO:0000255|HAMAP-Rule:MF_01522}.
CC   -!- SIMILARITY: Belongs to the HAK/KUP transporter (TC 2.A.72) family.
CC       {ECO:0000255|HAMAP-Rule:MF_01522}.
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DR   EMBL; CP000416; ABJ64015.1; -; Genomic_DNA.
DR   RefSeq; WP_011667606.1; NC_008497.1.
DR   AlphaFoldDB; Q03S07; -.
DR   STRING; 387344.LVIS_0875; -.
DR   EnsemblBacteria; ABJ64015; ABJ64015; LVIS_0875.
DR   KEGG; lbr:LVIS_0875; -.
DR   eggNOG; COG3158; Bacteria.
DR   HOGENOM; CLU_008142_4_1_9; -.
DR   OMA; TILLYEW; -.
DR   OrthoDB; 589903at2; -.
DR   Proteomes; UP000001652; Chromosome.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0015079; F:potassium ion transmembrane transporter activity; IEA:UniProtKB-UniRule.
DR   HAMAP; MF_01522; Kup; 1.
DR   InterPro; IPR003855; K+_transporter.
DR   InterPro; IPR023051; K+_uptake_low_affin.
DR   PANTHER; PTHR30540; PTHR30540; 1.
DR   Pfam; PF02705; K_trans; 1.
PE   3: Inferred from homology;
KW   Cell membrane; Ion transport; Membrane; Potassium; Potassium transport;
KW   Reference proteome; Transmembrane; Transmembrane helix; Transport.
FT   CHAIN           1..675
FT                   /note="Probable potassium transport system protein kup"
FT                   /id="PRO_0000279789"
FT   TRANSMEM        12..32
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01522"
FT   TRANSMEM        55..75
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01522"
FT   TRANSMEM        98..118
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01522"
FT   TRANSMEM        143..163
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01522"
FT   TRANSMEM        170..190
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01522"
FT   TRANSMEM        216..236
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01522"
FT   TRANSMEM        249..269
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01522"
FT   TRANSMEM        296..316
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01522"
FT   TRANSMEM        345..365
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01522"
FT   TRANSMEM        374..394
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01522"
FT   TRANSMEM        401..421
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01522"
FT   TRANSMEM        428..448
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01522"
SQ   SEQUENCE   675 AA;  75417 MW;  166F111FF31D09CB CRC64;
     MRKERLEKGS WLGMLITLGV VYGDIGTSPL YVMNALINDA GPLKNATPDY VIGSVSLIFW
     TLMLITTVKY VLVALRADNH HEGGIFALYA LVRHRAKWLI FVALIGGAAL LADGTLTPAV
     TVTSAVEGLK GLPDLRAFSQ YSWLVPLSVT LILVSLFTIQ VLGTAVVGRS FGPMMLLWFI
     VIGGIGLLNI SQAPAILRAF SPVYAIQVLF SPTNKMGIFI LGSVFLATTG AEALYSDMGH
     VGKANIDATW PFVYAMLILN YLGQGAWMLT HSQGPAWRNV TNINPFYEMI PSGGRIAMIV
     LATVAAIIAS QALITGSYTL VDEAVGLKFL PRMIIKHPSN VRSQIYIGAI NWLLCLVTLS
     IVWLFQTSAH MEAAYGLAIT LTMLMTTILL SQWVQMKGHR FWSLALLAGF GLLETLFLVA
     SLTKFIHGGY LTLGLTLMIF LIMVVWFFGN RRRLRYNQAD EQISLLNYRS QLIQLSQDDN
     QPLFATNLVY LAKVDQLHRV KRSILYSILD KRPKRAKVYW FITINETNRP YDCSYSVDML
     GTRNVVEVRL NLGFRKSQHI NRYLRAIVTS LIADHSIDPQ YSNYGITQPR QVGDFKFVVQ
     NQQIMDLAGN PTMHQFDRFL IGGRIFLQNI TPSPAIWYGL EFSDVLEETI PLFTKPMTDP
     ALVHLAKRQT TRHQV