ID   KUP_METBF               Reviewed;         603 AA.
AC   Q465T0;
DT   06-MAR-2007, integrated into UniProtKB/Swiss-Prot.
DT   13-SEP-2005, sequence version 1.
DT   25-MAY-2022, entry version 96.
DE   RecName: Full=Probable potassium transport system protein kup {ECO:0000255|HAMAP-Rule:MF_01522};
GN   Name=kup {ECO:0000255|HAMAP-Rule:MF_01522}; OrderedLocusNames=Mbar_A3491;
OS   Methanosarcina barkeri (strain Fusaro / DSM 804).
OC   Archaea; Euryarchaeota; Stenosarchaea group; Methanomicrobia;
OC   Methanosarcinales; Methanosarcinaceae; Methanosarcina.
OX   NCBI_TaxID=269797;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Fusaro / DSM 804;
RX   PubMed=16980466; DOI=10.1128/jb.00810-06;
RA   Maeder D.L., Anderson I., Brettin T.S., Bruce D.C., Gilna P., Han C.S.,
RA   Lapidus A., Metcalf W.W., Saunders E., Tapia R., Sowers K.R.;
RT   "The Methanosarcina barkeri genome: comparative analysis with
RT   Methanosarcina acetivorans and Methanosarcina mazei reveals extensive
RT   rearrangement within methanosarcinal genomes.";
RL   J. Bacteriol. 188:7922-7931(2006).
CC   -!- FUNCTION: Transport of potassium into the cell. {ECO:0000255|HAMAP-
CC       Rule:MF_01522}.
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000255|HAMAP-Rule:MF_01522};
CC       Multi-pass membrane protein {ECO:0000255|HAMAP-Rule:MF_01522}.
CC   -!- SIMILARITY: Belongs to the HAK/KUP transporter (TC 2.A.72) family.
CC       {ECO:0000255|HAMAP-Rule:MF_01522}.
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DR   EMBL; CP000099; AAZ72362.1; -; Genomic_DNA.
DR   RefSeq; WP_011308401.1; NC_007355.1.
DR   AlphaFoldDB; Q465T0; -.
DR   STRING; 269797.Mbar_A3491; -.
DR   EnsemblBacteria; AAZ72362; AAZ72362; Mbar_A3491.
DR   GeneID; 3624889; -.
DR   KEGG; mba:Mbar_A3491; -.
DR   eggNOG; arCOG05242; Archaea.
DR   HOGENOM; CLU_008142_4_2_2; -.
DR   OMA; AADQFEI; -.
DR   OrthoDB; 8415at2157; -.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0015079; F:potassium ion transmembrane transporter activity; IEA:UniProtKB-UniRule.
DR   HAMAP; MF_01522; Kup; 1.
DR   InterPro; IPR003855; K+_transporter.
DR   InterPro; IPR023051; K+_uptake_low_affin.
DR   PANTHER; PTHR30540; PTHR30540; 1.
DR   Pfam; PF02705; K_trans; 1.
PE   3: Inferred from homology;
KW   Cell membrane; Ion transport; Membrane; Potassium; Potassium transport;
KW   Transmembrane; Transmembrane helix; Transport.
FT   CHAIN           1..603
FT                   /note="Probable potassium transport system protein kup"
FT                   /id="PRO_0000279847"
FT   TRANSMEM        15..35
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01522"
FT   TRANSMEM        43..63
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01522"
FT   TRANSMEM        94..114
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01522"
FT   TRANSMEM        135..155
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01522"
FT   TRANSMEM        163..183
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01522"
FT   TRANSMEM        209..229
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01522"
FT   TRANSMEM        244..264
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01522"
FT   TRANSMEM        283..303
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01522"
FT   TRANSMEM        336..356
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01522"
FT   TRANSMEM        365..385
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01522"
FT   TRANSMEM        390..410
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01522"
FT   TRANSMEM        415..435
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01522"
SQ   SEQUENCE   603 AA;  67639 MW;  D66CEA0503DE21FB CRC64;
     MFSKSEFREV VKSMGLVFGD IGTSPIYTLT VIFLLTRPTH THIIGVLSLI IWTLIILVTV
     EYAWLAMSLG KKGEGGTIVL KEILVPLLKS SRNVAFVTLL AYIGTSFLMG DGVITPAISI
     LSAVEGLRII PQFENIGQST IILISAAIAI ALFSVQSKGI EKITWVFGPI MVLWFATIGF
     SGIASIFYTP EVLKAINPYY AIRFLLDNGI IGFFVLSEVI LCATGGEALY ADMGHLGREP
     ILKAWRFVFL ALVLNYLGQG AFLIRNPGST NFLFEMINQQ ANILYIPFLL LSVVATIIAS
     QAMISGMFSI VYQGITTRII PMLKIDYTSG VFKSQIYIST VNWLLLVSVL FMMLIFKESS
     KLAAAYGLAV TGTMSITGIM MTSIFYHRKN ITKALISLFI TFIDVVFLLS NSYKIPHGGY
     WSVIIALFIL SLILIYTSGQ KKLYKLMKLM KSKDFLEKYK QVYATQNKIM GTALFFTRDI
     ERIPQYISHV MFKNNIIYEN NIFISIIKSD SPFGIETSFT KEPAKGLKIL EIRAGYMEIV
     NVEKILKDQG IGEKTIFYGV EDIFTKNIIW RIFSIIKKVS PSFVQFYKLP TDELHGVMTR
     FEM