ID   KUP_MYXXD               Reviewed;         653 AA.
AC   Q1DFF8;
DT   06-MAR-2007, integrated into UniProtKB/Swiss-Prot.
DT   11-JUL-2006, sequence version 1.
DT   03-AUG-2022, entry version 97.
DE   RecName: Full=Probable potassium transport system protein kup {ECO:0000255|HAMAP-Rule:MF_01522};
GN   Name=kup {ECO:0000255|HAMAP-Rule:MF_01522}; OrderedLocusNames=MXAN_0341;
OS   Myxococcus xanthus (strain DK1622).
OC   Bacteria; Proteobacteria; Deltaproteobacteria; Myxococcales;
OC   Cystobacterineae; Myxococcaceae; Myxococcus.
OX   NCBI_TaxID=246197;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=DK1622;
RX   PubMed=17015832; DOI=10.1073/pnas.0607335103;
RA   Goldman B.S., Nierman W.C., Kaiser D., Slater S.C., Durkin A.S., Eisen J.,
RA   Ronning C.M., Barbazuk W.B., Blanchard M., Field C., Halling C., Hinkle G.,
RA   Iartchuk O., Kim H.S., Mackenzie C., Madupu R., Miller N., Shvartsbeyn A.,
RA   Sullivan S.A., Vaudin M., Wiegand R., Kaplan H.B.;
RT   "Evolution of sensory complexity recorded in a myxobacterial genome.";
RL   Proc. Natl. Acad. Sci. U.S.A. 103:15200-15205(2006).
CC   -!- FUNCTION: Transport of potassium into the cell. {ECO:0000255|HAMAP-
CC       Rule:MF_01522}.
CC   -!- SUBCELLULAR LOCATION: Cell inner membrane {ECO:0000255|HAMAP-
CC       Rule:MF_01522}; Multi-pass membrane protein {ECO:0000255|HAMAP-
CC       Rule:MF_01522}.
CC   -!- SIMILARITY: Belongs to the HAK/KUP transporter (TC 2.A.72) family.
CC       {ECO:0000255|HAMAP-Rule:MF_01522}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; CP000113; ABF87568.1; -; Genomic_DNA.
DR   RefSeq; WP_011550479.1; NC_008095.1.
DR   AlphaFoldDB; Q1DFF8; -.
DR   STRING; 246197.MXAN_0341; -.
DR   EnsemblBacteria; ABF87568; ABF87568; MXAN_0341.
DR   GeneID; 41357839; -.
DR   KEGG; mxa:MXAN_0341; -.
DR   eggNOG; COG3158; Bacteria.
DR   HOGENOM; CLU_008142_4_2_7; -.
DR   OMA; AADQFEI; -.
DR   OrthoDB; 589903at2; -.
DR   Proteomes; UP000002402; Chromosome.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0015079; F:potassium ion transmembrane transporter activity; IEA:UniProtKB-UniRule.
DR   HAMAP; MF_01522; Kup; 1.
DR   InterPro; IPR003855; K+_transporter.
DR   InterPro; IPR023051; K+_uptake_low_affin.
DR   PANTHER; PTHR30540; PTHR30540; 1.
DR   Pfam; PF02705; K_trans; 1.
PE   3: Inferred from homology;
KW   Cell inner membrane; Cell membrane; Ion transport; Membrane; Potassium;
KW   Potassium transport; Reference proteome; Transmembrane;
KW   Transmembrane helix; Transport.
FT   CHAIN           1..653
FT                   /note="Probable potassium transport system protein kup"
FT                   /id="PRO_0000279801"
FT   TRANSMEM        37..57
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01522"
FT   TRANSMEM        79..99
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01522"
FT   TRANSMEM        134..154
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01522"
FT   TRANSMEM        168..188
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01522"
FT   TRANSMEM        196..216
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01522"
FT   TRANSMEM        243..263
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01522"
FT   TRANSMEM        278..298
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01522"
FT   TRANSMEM        320..340
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01522"
FT   TRANSMEM        368..388
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01522"
FT   TRANSMEM        397..417
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01522"
FT   TRANSMEM        426..446
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01522"
FT   TRANSMEM        450..470
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01522"
SQ   SEQUENCE   653 AA;  70640 MW;  889370B540D35F38 CRC64;
     MLQARVQLKR GFVKATTTGV PGGEDVKKGP DTFKRSALLA LGALGIVYGD IGTSPLYALR
     ECFTGAHGIP PTPANVLGVL SLIFWSLIIV VSVKYLLLVM KADNRGEGGI LAMMALVMQR
     QRAQPSHRSR PMLITLGIFG AALLYGDGII TPAITVLSAV EGLHVATAVF DPYVIPIALV
     ILVALFLVQR HGTADIGAVF GPVMCIWFLT LAGLGVKELV HNPAVLGALS PWHAVELFRH
     NHLHGFLVLG GVFLVVTGCE ALYADMGHFG RKPIQLAWFS MVLPALMLNY LGQGALLLRD
     ASAARNPFFL LAPSWLLYPL VALATVAGVI ASQALIAGVF SLTRQAMQLG YSPRMEVVHT
     SAEEMGQIYL PGLNWALLVG VVALVLGFRS SSALASAYGI AVSTAMVITT LMAYVVAREL
     WGVRRWVAIP VVGLFLSVEL AFFGANAVKV ADGGWFPLLM AVVVFTLMTT WKRGRDILAA
     KLRASSIPLK VLLGSFGDHP PVRVPGTAIF MTGNAEGTPP ALLHNLKHNK VLHEQVVLLT
     ILSEELPHVP HSERVEVEPL EQGFVRVVAR YGFMENPGIP DVLKRCREKG LQFQLMGTSF
     FLGRETLIPT KRPGMAVWRE ALFAWMSRNA RSATAYFRIP PNRVVELGAQ VEL