KUP_PECAS
ID KUP_PECAS Reviewed; 622 AA.
AC Q6DB92;
DT 27-SEP-2004, integrated into UniProtKB/Swiss-Prot.
DT 16-AUG-2004, sequence version 1.
DT 25-MAY-2022, entry version 94.
DE RecName: Full=Low affinity potassium transport system protein kup;
DE AltName: Full=Kup system potassium uptake protein;
GN Name=kup; OrderedLocusNames=ECA0006;
OS Pectobacterium atrosepticum (strain SCRI 1043 / ATCC BAA-672) (Erwinia
OS carotovora subsp. atroseptica).
OC Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC Pectobacteriaceae; Pectobacterium.
OX NCBI_TaxID=218491;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=SCRI 1043 / ATCC BAA-672;
RX PubMed=15263089; DOI=10.1073/pnas.0402424101;
RA Bell K.S., Sebaihia M., Pritchard L., Holden M.T.G., Hyman L.J.,
RA Holeva M.C., Thomson N.R., Bentley S.D., Churcher L.J.C., Mungall K.,
RA Atkin R., Bason N., Brooks K., Chillingworth T., Clark K., Doggett J.,
RA Fraser A., Hance Z., Hauser H., Jagels K., Moule S., Norbertczak H.,
RA Ormond D., Price C., Quail M.A., Sanders M., Walker D., Whitehead S.,
RA Salmond G.P.C., Birch P.R.J., Parkhill J., Toth I.K.;
RT "Genome sequence of the enterobacterial phytopathogen Erwinia carotovora
RT subsp. atroseptica and characterization of virulence factors.";
RL Proc. Natl. Acad. Sci. U.S.A. 101:11105-11110(2004).
CC -!- FUNCTION: Responsible for the low-affinity transport of potassium into
CC the cell, with the probable concomitant uptake of protons (symport
CC system). {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Cell inner membrane {ECO:0000250}; Multi-pass
CC membrane protein {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the HAK/KUP transporter (TC 2.A.72) family.
CC {ECO:0000305}.
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DR EMBL; BX950851; CAG72930.1; -; Genomic_DNA.
DR RefSeq; WP_011091655.1; NC_004547.2.
DR AlphaFoldDB; Q6DB92; -.
DR STRING; 218491.ECA0006; -.
DR EnsemblBacteria; CAG72930; CAG72930; ECA0006.
DR GeneID; 57206860; -.
DR KEGG; eca:ECA0006; -.
DR PATRIC; fig|218491.5.peg.6; -.
DR eggNOG; COG3158; Bacteria.
DR HOGENOM; CLU_008142_4_2_6; -.
DR OMA; AADQFEI; -.
DR OrthoDB; 589903at2; -.
DR Proteomes; UP000007966; Chromosome.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0015079; F:potassium ion transmembrane transporter activity; IEA:UniProtKB-UniRule.
DR GO; GO:0015293; F:symporter activity; IEA:UniProtKB-UniRule.
DR HAMAP; MF_01522; Kup; 1.
DR InterPro; IPR003855; K+_transporter.
DR InterPro; IPR023051; K+_uptake_low_affin.
DR PANTHER; PTHR30540; PTHR30540; 1.
DR Pfam; PF02705; K_trans; 1.
DR TIGRFAMs; TIGR00794; kup; 1.
PE 3: Inferred from homology;
KW Cell inner membrane; Cell membrane; Ion transport; Membrane; Potassium;
KW Potassium transport; Reference proteome; Symport; Transmembrane;
KW Transmembrane helix; Transport.
FT CHAIN 1..622
FT /note="Low affinity potassium transport system protein kup"
FT /id="PRO_0000209015"
FT TOPO_DOM 1..6
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 7..29
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 30..48
FT /note="Periplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 49..71
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 72..101
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 102..124
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 125..133
FT /note="Periplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 134..156
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 157..167
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 168..190
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 191..209
FT /note="Periplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 210..232
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 233..244
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 245..267
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 268..286
FT /note="Periplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 287..309
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 310..333
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 334..356
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 357..365
FT /note="Periplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 366..388
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 389..394
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 395..417
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 418..421
FT /note="Periplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 422..440
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 441..622
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
SQ SEQUENCE 622 AA; 69122 MW; B93DACD908C2557F CRC64;
MSSEHKRSLP AVTLAAIGVV YGDIGTSPLY TLRECLSGQF GFGVEPHSVF GFLSLIFWLL
VLVVSLKYLT YVMRADNAGE GGILTLMSLA GRNTSDRMTS VLVIMGLIGG SFFYGEVVIT
PAISVMSAME GLEIAAPAMD SYIVPLSIVV LTLLFIIQKH GTGSVGKLFA PVMLIWFLTL
GVLGVRGIIA NPEVLQALNP MYAVRFFIEY KAVSFFALGA VVLAITGVEA LYADMGHFGK
FPIRLAWFTV VLPSLVLNYF GQGALLLKNP EAIKNPFFLL APDWALIPLM VLATLATVIA
SQAVISGVFS LTRQAVRLGY LPPMRIVHTS DMESGQIYIP AINWMLYIAV VIVIVSFEHS
SNLAAAYGIA VTGTMVITSI LFCTVAVKNW LWNRYLAWVL LVGLLIIDVP MFLANVVKIL
SGGWLPLALG MVMFIIMTTW KSERFRLLRR LHEHGNSLDA MIASLEKSPP TRVPGTAVYF
SRATRVIPFA LLHNLKHNKI LHERVVLLTM RTEDAPYVLN ARRVTVEQLS PTFWRVIANY
GWRETPDVEE VFQRCWQEGL TCQMMETSFF MSNESLIIGE RPWYLRLRGK LFMMLSRNAL
RAADQFEIPP NRLIELGIQV EI
