KUP_PSEAE
ID KUP_PSEAE Reviewed; 634 AA.
AC Q9I540;
DT 27-SEP-2004, integrated into UniProtKB/Swiss-Prot.
DT 01-MAR-2001, sequence version 1.
DT 03-AUG-2022, entry version 96.
DE RecName: Full=Probable potassium transport system protein kup {ECO:0000255|HAMAP-Rule:MF_01522};
GN Name=kup {ECO:0000255|HAMAP-Rule:MF_01522}; OrderedLocusNames=PA0917;
OS Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM
OS 14847 / LMG 12228 / 1C / PRS 101 / PAO1).
OC Bacteria; Proteobacteria; Gammaproteobacteria; Pseudomonadales;
OC Pseudomonadaceae; Pseudomonas.
OX NCBI_TaxID=208964;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C /
RC PRS 101 / PAO1;
RX PubMed=10984043; DOI=10.1038/35023079;
RA Stover C.K., Pham X.-Q.T., Erwin A.L., Mizoguchi S.D., Warrener P.,
RA Hickey M.J., Brinkman F.S.L., Hufnagle W.O., Kowalik D.J., Lagrou M.,
RA Garber R.L., Goltry L., Tolentino E., Westbrock-Wadman S., Yuan Y.,
RA Brody L.L., Coulter S.N., Folger K.R., Kas A., Larbig K., Lim R.M.,
RA Smith K.A., Spencer D.H., Wong G.K.-S., Wu Z., Paulsen I.T., Reizer J.,
RA Saier M.H. Jr., Hancock R.E.W., Lory S., Olson M.V.;
RT "Complete genome sequence of Pseudomonas aeruginosa PAO1, an opportunistic
RT pathogen.";
RL Nature 406:959-964(2000).
CC -!- FUNCTION: Transport of potassium into the cell. {ECO:0000255|HAMAP-
CC Rule:MF_01522}.
CC -!- SUBCELLULAR LOCATION: Cell inner membrane {ECO:0000255|HAMAP-
CC Rule:MF_01522}; Multi-pass membrane protein {ECO:0000255|HAMAP-
CC Rule:MF_01522}.
CC -!- SIMILARITY: Belongs to the HAK/KUP transporter (TC 2.A.72) family.
CC {ECO:0000255|HAMAP-Rule:MF_01522}.
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DR EMBL; AE004091; AAG04306.1; -; Genomic_DNA.
DR PIR; C83530; C83530.
DR RefSeq; NP_249608.1; NC_002516.2.
DR RefSeq; WP_003104754.1; NZ_QZGE01000007.1.
DR AlphaFoldDB; Q9I540; -.
DR STRING; 287.DR97_1023; -.
DR PaxDb; Q9I540; -.
DR PRIDE; Q9I540; -.
DR EnsemblBacteria; AAG04306; AAG04306; PA0917.
DR GeneID; 880673; -.
DR KEGG; pae:PA0917; -.
DR PATRIC; fig|208964.12.peg.952; -.
DR PseudoCAP; PA0917; -.
DR HOGENOM; CLU_008142_4_2_6; -.
DR InParanoid; Q9I540; -.
DR OMA; AADQFEI; -.
DR PhylomeDB; Q9I540; -.
DR BioCyc; PAER208964:G1FZ6-936-MON; -.
DR Proteomes; UP000002438; Chromosome.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0016020; C:membrane; IBA:GO_Central.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0015079; F:potassium ion transmembrane transporter activity; IBA:GO_Central.
DR GO; GO:0006813; P:potassium ion transport; IBA:GO_Central.
DR HAMAP; MF_01522; Kup; 1.
DR InterPro; IPR003855; K+_transporter.
DR InterPro; IPR023051; K+_uptake_low_affin.
DR PANTHER; PTHR30540; PTHR30540; 1.
DR Pfam; PF02705; K_trans; 1.
PE 3: Inferred from homology;
KW Cell inner membrane; Cell membrane; Ion transport; Membrane; Potassium;
KW Potassium transport; Reference proteome; Transmembrane;
KW Transmembrane helix; Transport.
FT CHAIN 1..634
FT /note="Probable potassium transport system protein kup"
FT /id="PRO_0000209040"
FT TRANSMEM 19..39
FT /note="Helical"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01522"
FT TRANSMEM 62..82
FT /note="Helical"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01522"
FT TRANSMEM 113..133
FT /note="Helical"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01522"
FT TRANSMEM 150..170
FT /note="Helical"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01522"
FT TRANSMEM 177..197
FT /note="Helical"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01522"
FT TRANSMEM 225..245
FT /note="Helical"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01522"
FT TRANSMEM 259..279
FT /note="Helical"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01522"
FT TRANSMEM 291..311
FT /note="Helical"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01522"
FT TRANSMEM 349..369
FT /note="Helical"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01522"
FT TRANSMEM 379..399
FT /note="Helical"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01522"
FT TRANSMEM 406..426
FT /note="Helical"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01522"
FT TRANSMEM 431..451
FT /note="Helical"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01522"
SQ SEQUENCE 634 AA; 68735 MW; 5D4CBA5F70CCBE99 CRC64;
MSDAATRAEE TSEGHSSSAI GLMVGAVGVC YGDIGTSPLY TLKEVFIGGY GVQANHDGVL
GVLSLIFWSL VWVVSIKYVI FVLRADNQGE GGVMALSALA RRAAAPFGRL QTFVVVAGLI
GAALFYGDSM ITPAISVLSA VEGLEIAFDG LEHWTVPLAL IVLIGLFLIQ KHGTARIGIL
FGPVMVLWFG ALAALGVYGV IQQPEVLQAM NPVWAVRFFS SHPGIGVAIL GATVLALTGA
EALYADMGHF GRKPIARAWF LLVLPALVLN YFGQGATILS NAEAARNPFY LLAPGWALLP
MVALSTLATV IASQAVISGA FSLTRQAIQL GYVPRMTIQH TSSHEQGQIY IGGVNWALMV
GVVLLVLGFE SSASLAAAYG VAVTGTMLIT TLLMGVVIWR LWKWPLWLGV PFFCVMLAVD
SLFFAANLPK VIQGGAFPVI AGIVIFILMS TWKRGRQLLV ERLDEGSLPL SVFISSMRVQ
PPHRVQGTAV FLTARTDAVP HALLHNLLHN QVLHEQVVLL TVVNEDSPRV SPDRRFEVEA
YGDGFFRVIL HFGFMEEPDI PAALRLCHLN ELDFSPMRTT YFLSRETVIP SKRIGMARWR
EGLFAFLLKN ANGNLRYFNL PLNRVIELGT QVEI
