ID   KUP_SALCH               Reviewed;         622 AA.
AC   Q57HW3;
DT   30-AUG-2005, integrated into UniProtKB/Swiss-Prot.
DT   10-MAY-2005, sequence version 1.
DT   25-MAY-2022, entry version 77.
DE   RecName: Full=Low affinity potassium transport system protein kup;
DE   AltName: Full=Kup system potassium uptake protein;
GN   Name=kup; OrderedLocusNames=SCH_3793;
OS   Salmonella choleraesuis (strain SC-B67).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC   Enterobacteriaceae; Salmonella.
OX   NCBI_TaxID=321314;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=SC-B67;
RX   PubMed=15781495; DOI=10.1093/nar/gki297;
RA   Chiu C.-H., Tang P., Chu C., Hu S., Bao Q., Yu J., Chou Y.-Y., Wang H.-S.,
RA   Lee Y.-S.;
RT   "The genome sequence of Salmonella enterica serovar Choleraesuis, a highly
RT   invasive and resistant zoonotic pathogen.";
RL   Nucleic Acids Res. 33:1690-1698(2005).
CC   -!- FUNCTION: Responsible for the low-affinity transport of potassium into
CC       the cell, with the probable concomitant uptake of protons (symport
CC       system). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cell inner membrane {ECO:0000250}; Multi-pass
CC       membrane protein {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the HAK/KUP transporter (TC 2.A.72) family.
CC       {ECO:0000305}.
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DR   EMBL; AE017220; AAX67699.1; -; Genomic_DNA.
DR   RefSeq; WP_000102338.1; NC_006905.1.
DR   AlphaFoldDB; Q57HW3; -.
DR   EnsemblBacteria; AAX67699; AAX67699; SCH_3793.
DR   KEGG; sec:SCH_3793; -.
DR   HOGENOM; CLU_008142_4_2_6; -.
DR   OMA; AADQFEI; -.
DR   Proteomes; UP000000538; Chromosome.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0015079; F:potassium ion transmembrane transporter activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0015293; F:symporter activity; IEA:UniProtKB-UniRule.
DR   HAMAP; MF_01522; Kup; 1.
DR   InterPro; IPR003855; K+_transporter.
DR   InterPro; IPR023051; K+_uptake_low_affin.
DR   PANTHER; PTHR30540; PTHR30540; 1.
DR   Pfam; PF02705; K_trans; 1.
DR   TIGRFAMs; TIGR00794; kup; 1.
PE   3: Inferred from homology;
KW   Cell inner membrane; Cell membrane; Ion transport; Membrane; Potassium;
KW   Potassium transport; Symport; Transmembrane; Transmembrane helix;
KW   Transport.
FT   CHAIN           1..622
FT                   /note="Low affinity potassium transport system protein kup"
FT                   /id="PRO_0000209054"
FT   TOPO_DOM        1..8
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        9..29
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        30..48
FT                   /note="Periplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        49..69
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        70..102
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        103..123
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        124..136
FT                   /note="Periplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        137..157
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        158..164
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        165..185
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        186..212
FT                   /note="Periplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        213..233
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        234..246
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        247..267
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        268..286
FT                   /note="Periplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        287..309
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        310..336
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        337..357
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        358..362
FT                   /note="Periplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        363..383
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        384..395
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        396..416
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        417..418
FT                   /note="Periplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        419..439
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        440..622
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   622 AA;  69301 MW;  B2A8B46D4D503E6A CRC64;
     MSTDNKQSLP AITLAAIGVV YGDIGTSPLY TLRECLSGQF GFGVERDAVF GFLSLIFWLL
     IFVVSIKYLT FVMRADNAGE GGILTLMSLA GRNTSARTTS MLVIMGLIGG SFFYGEVVIT
     PAISVMSAIE GLEIVAPQLD TWIVPLSIIV LTLLFMIQKH GTGMVGKLFA PIMLTWFLIL
     AVLGLRSIIA NPEVLHALNP VWAVRFFLEY KTVSFIALGA VVLSITGVEA LYADMGHFGK
     FPIRLAWFTV VLPSLVLNYF GQGALLLKHP EAIKNPFFLL APDWALIPLL ILAALATVIA
     SQAVISGVFS LTRQAVRLGY LSPMRIIHTS EMESGQIYIP FVNWLLYFAV VVVIVSFEHS
     SNLAAAYGIA VTGTMVLTSI LSTTVARKNW HWNKYFVALI LIAFLCVDIP LFSANLDKLL
     SGGWLPLSLG LIMFTIMTTW KSERFRLLRR MHEHGNSLEA MIASLEKSPP VRVPGTAVYM
     SRALSVIPFA LLHNLKHNKV LHERVILLTL RTEDAPYVHN VRRVQIEQLS PTFWRVVASY
     GWRETPNVEE VFHRCGLEGL SCRMMETSFF MSHESLIVGK RPWYLRLRGK LYLLLQRNAL
     RAPDQFEIPP NRVIELGTQV EI