ID   KUP_STRE4               Reviewed;         667 AA.
AC   C0M958;
DT   28-JUL-2009, integrated into UniProtKB/Swiss-Prot.
DT   05-MAY-2009, sequence version 1.
DT   25-MAY-2022, entry version 60.
DE   RecName: Full=Probable potassium transport system protein kup {ECO:0000255|HAMAP-Rule:MF_01522};
GN   Name=kup {ECO:0000255|HAMAP-Rule:MF_01522}; OrderedLocusNames=SEQ_0671;
OS   Streptococcus equi subsp. equi (strain 4047).
OC   Bacteria; Firmicutes; Bacilli; Lactobacillales; Streptococcaceae;
OC   Streptococcus.
OX   NCBI_TaxID=553482;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=4047;
RX   PubMed=19325880; DOI=10.1371/journal.ppat.1000346;
RA   Holden M.T.G., Heather Z., Paillot R., Steward K.F., Webb K., Ainslie F.,
RA   Jourdan T., Bason N.C., Holroyd N.E., Mungall K., Quail M.A., Sanders M.,
RA   Simmonds M., Willey D., Brooks K., Aanensen D.M., Spratt B.G., Jolley K.A.,
RA   Maiden M.C.J., Kehoe M., Chanter N., Bentley S.D., Robinson C.,
RA   Maskell D.J., Parkhill J., Waller A.S.;
RT   "Genomic evidence for the evolution of Streptococcus equi: host
RT   restriction, increased virulence, and genetic exchange with human
RT   pathogens.";
RL   PLoS Pathog. 5:E1000346-E1000346(2009).
CC   -!- FUNCTION: Transport of potassium into the cell. {ECO:0000255|HAMAP-
CC       Rule:MF_01522}.
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000255|HAMAP-Rule:MF_01522};
CC       Multi-pass membrane protein {ECO:0000255|HAMAP-Rule:MF_01522}.
CC   -!- SIMILARITY: Belongs to the HAK/KUP transporter (TC 2.A.72) family.
CC       {ECO:0000255|HAMAP-Rule:MF_01522}.
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DR   EMBL; FM204883; CAW93009.1; -; Genomic_DNA.
DR   RefSeq; WP_012679205.1; NC_012471.1.
DR   AlphaFoldDB; C0M958; -.
DR   PRIDE; C0M958; -.
DR   EnsemblBacteria; CAW93009; CAW93009; SEQ_0671.
DR   KEGG; seu:SEQ_0671; -.
DR   HOGENOM; CLU_008142_4_1_9; -.
DR   OMA; AADQFEI; -.
DR   OrthoDB; 589903at2; -.
DR   Proteomes; UP000001365; Chromosome.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0015079; F:potassium ion transmembrane transporter activity; IEA:UniProtKB-UniRule.
DR   HAMAP; MF_01522; Kup; 1.
DR   InterPro; IPR003855; K+_transporter.
DR   InterPro; IPR023051; K+_uptake_low_affin.
DR   PANTHER; PTHR30540; PTHR30540; 1.
DR   Pfam; PF02705; K_trans; 1.
PE   3: Inferred from homology;
KW   Cell membrane; Ion transport; Membrane; Potassium; Potassium transport;
KW   Transmembrane; Transmembrane helix; Transport.
FT   CHAIN           1..667
FT                   /note="Probable potassium transport system protein kup"
FT                   /id="PRO_1000185120"
FT   TRANSMEM        16..36
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01522"
FT   TRANSMEM        58..78
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01522"
FT   TRANSMEM        101..121
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01522"
FT   TRANSMEM        146..166
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01522"
FT   TRANSMEM        167..187
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01522"
FT   TRANSMEM        221..241
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01522"
FT   TRANSMEM        253..273
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01522"
FT   TRANSMEM        294..314
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01522"
FT   TRANSMEM        343..363
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01522"
FT   TRANSMEM        373..393
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01522"
FT   TRANSMEM        399..419
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01522"
FT   TRANSMEM        424..444
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01522"
SQ   SEQUENCE   667 AA;  74259 MW;  DD93E8B242F06AC8 CRC64;
     MSNAHHDAFD KATKAGFIIA LGIVYGDIGT SPLYTMQSLV DNQGGLSQVS EAFILGSVSL
     IIWTLTLVTT IKYVLIALKA DNHHEGGIFS LFTLVRRMSR WLIIPAMLGG ATLLSDGALT
     PAVTVTSAIE GLKAVPELSS IYQNQTNVIL TTLLILMVLF GLQRFGTGVI GKLFGPVMLV
     WFSVLGISGL LNSLQHLEIL KAINPYYALH LLVSPENHRG IFILGSIFLA TTGAEALYSD
     LGHVGRGNIY ASWPFVKVCI ILSYCGQAAW ILAHKDSGIA LNPFFASVPE GLRVYLVILA
     TLAAIIASQA LISGSFTLVS EAMRLKIFPL FKITYPGANL GQLYIPVINW SLFAVTSCTV
     LYFRTSAHME AAYGLAITIT MLMTTILLAY YLIKEGVKPL LASLLMAFFA FIEFIFFLAS
     AVKFMHGGYV VVVLALAIVF VMVIWHAGTM IVAKYVKSLS LNDYKHQIKL LRDDLRFDLY
     QTNVVYLTNR MKKDLIDRSI LYSILDKRPK RAQVYWFVNV RVTDEPYTAT YKVDMLETDY
     IVCVELYLGF RMPQTVPRYL RTIVQDLMES GRLPKQAQDY TITPGREVGD FRFVIIEERV
     SHARQLSTLE RFVMQTKASI KHVTASPMRW FGLQYSEATV EVVPLLLSDV LKLPIKEIKA
     CTKDEKA