ID   KUP_STREM               Reviewed;         667 AA.
AC   B4U1Z7;
DT   14-APR-2009, integrated into UniProtKB/Swiss-Prot.
DT   23-SEP-2008, sequence version 1.
DT   25-MAY-2022, entry version 62.
DE   RecName: Full=Probable potassium transport system protein kup {ECO:0000255|HAMAP-Rule:MF_01522};
GN   Name=kup {ECO:0000255|HAMAP-Rule:MF_01522}; OrderedLocusNames=Sez_0647;
OS   Streptococcus equi subsp. zooepidemicus (strain MGCS10565).
OC   Bacteria; Firmicutes; Bacilli; Lactobacillales; Streptococcaceae;
OC   Streptococcus.
OX   NCBI_TaxID=552526;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=MGCS10565;
RX   PubMed=18716664; DOI=10.1371/journal.pone.0003026;
RA   Beres S.B., Sesso R., Pinto S.W.L., Hoe N.P., Porcella S.F., Deleo F.R.,
RA   Musser J.M.;
RT   "Genome sequence of a lancefield group C Streptococcus zooepidemicus strain
RT   causing epidemic nephritis: new information about an old disease.";
RL   PLoS ONE 3:E3026-E3026(2008).
CC   -!- FUNCTION: Transport of potassium into the cell. {ECO:0000255|HAMAP-
CC       Rule:MF_01522}.
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000255|HAMAP-Rule:MF_01522};
CC       Multi-pass membrane protein {ECO:0000255|HAMAP-Rule:MF_01522}.
CC   -!- SIMILARITY: Belongs to the HAK/KUP transporter (TC 2.A.72) family.
CC       {ECO:0000255|HAMAP-Rule:MF_01522}.
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DR   EMBL; CP001129; ACG62014.1; -; Genomic_DNA.
DR   RefSeq; WP_012515290.1; NC_011134.1.
DR   AlphaFoldDB; B4U1Z7; -.
DR   EnsemblBacteria; ACG62014; ACG62014; Sez_0647.
DR   KEGG; sez:Sez_0647; -.
DR   HOGENOM; CLU_008142_4_1_9; -.
DR   OMA; AADQFEI; -.
DR   Proteomes; UP000001873; Chromosome.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0015079; F:potassium ion transmembrane transporter activity; IEA:UniProtKB-UniRule.
DR   HAMAP; MF_01522; Kup; 1.
DR   InterPro; IPR003855; K+_transporter.
DR   InterPro; IPR023051; K+_uptake_low_affin.
DR   PANTHER; PTHR30540; PTHR30540; 1.
DR   Pfam; PF02705; K_trans; 1.
PE   3: Inferred from homology;
KW   Cell membrane; Ion transport; Membrane; Potassium; Potassium transport;
KW   Transmembrane; Transmembrane helix; Transport.
FT   CHAIN           1..667
FT                   /note="Probable potassium transport system protein kup"
FT                   /id="PRO_1000190285"
FT   TRANSMEM        16..36
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01522"
FT   TRANSMEM        58..78
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01522"
FT   TRANSMEM        101..121
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01522"
FT   TRANSMEM        146..166
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01522"
FT   TRANSMEM        167..187
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01522"
FT   TRANSMEM        221..241
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01522"
FT   TRANSMEM        253..273
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01522"
FT   TRANSMEM        294..314
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01522"
FT   TRANSMEM        343..363
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01522"
FT   TRANSMEM        373..393
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01522"
FT   TRANSMEM        399..419
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01522"
FT   TRANSMEM        431..451
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01522"
SQ   SEQUENCE   667 AA;  74197 MW;  FAA683923797520C CRC64;
     MSNAHHDAFD KATKAGFIIA LGIVYGDIGT SPLYTMQSLV DNQGGLSQVS EAFILGSVSL
     IIWTLTLITT IKYVLIALKA DNHHEGGIFS LFTLVRRMSR WLIIPAMLGG ATLLSDGALT
     PAVTVTSAIE GLKAVPELSS IYQNQTNVIL TTLLILMVLF GLQRFGTGVI GKLFGPVMLV
     WFSVLGISGL LNSLQHLEIL KAINPYYALH LLVSPENHRG IFILGSIFLA TTGAEALYSD
     LGHVGRGNIY ASWPFVKVCI ILSYCGQAAW ILAHKDSGIA LNPFFASVPE GLRVYLVILA
     TLAAIIASQA LISGSFTLVS EAMRLKIFPL FKITYPGANL GQLYIPVINW SLFAVTSCTV
     LYFRTSAHME AAYGLAITIT MLMTTILLAY YLIKEGVKPL LASLLMAFFA FIEFIFFLAS
     AVKFMHGGYV VVVLALAIVF VMVIWHAGTV IVAKYVKSLS LNDYKHQIKL LRDDLRFDLY
     QTNVVYLTNR MKKDLIDRSI LYSILDKRPK RAQVYWFVNV RVTDEPYTAT YKVDMLGTDY
     IVCVELYLGF RMPQTVPRYL RTIVQDLMES GRLPKQVQDY TITPGREVGD FRFVIIEERV
     SHARQLSTLE RFVMQTKASI KHVTASPMRW FGLQYSEATV EVVPLLLSDV LKLPIKEIKA
     CTKDEKA