KUP_STRP1
ID KUP_STRP1 Reviewed; 666 AA.
AC Q99Z39; Q48Y04; Q48Y05;
DT 27-SEP-2004, integrated into UniProtKB/Swiss-Prot.
DT 01-JUN-2001, sequence version 1.
DT 25-MAY-2022, entry version 131.
DE RecName: Full=Probable potassium transport system protein kup {ECO:0000255|HAMAP-Rule:MF_01522};
GN Name=kup {ECO:0000255|HAMAP-Rule:MF_01522};
GN OrderedLocusNames=SPy_1414, M5005_Spy1152; ORFNames=M5005_Spy1153;
OS Streptococcus pyogenes serotype M1.
OC Bacteria; Firmicutes; Bacilli; Lactobacillales; Streptococcaceae;
OC Streptococcus.
OX NCBI_TaxID=301447;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 700294 / SF370 / Serotype M1;
RX PubMed=11296296; DOI=10.1073/pnas.071559398;
RA Ferretti J.J., McShan W.M., Ajdic D.J., Savic D.J., Savic G., Lyon K.,
RA Primeaux C., Sezate S., Suvorov A.N., Kenton S., Lai H.S., Lin S.P.,
RA Qian Y., Jia H.G., Najar F.Z., Ren Q., Zhu H., Song L., White J., Yuan X.,
RA Clifton S.W., Roe B.A., McLaughlin R.E.;
RT "Complete genome sequence of an M1 strain of Streptococcus pyogenes.";
RL Proc. Natl. Acad. Sci. U.S.A. 98:4658-4663(2001).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC BAA-947 / MGAS5005 / Serotype M1;
RX PubMed=16088826; DOI=10.1086/432514;
RA Sumby P., Porcella S.F., Madrigal A.G., Barbian K.D., Virtaneva K.,
RA Ricklefs S.M., Sturdevant D.E., Graham M.R., Vuopio-Varkila J., Hoe N.P.,
RA Musser J.M.;
RT "Evolutionary origin and emergence of a highly successful clone of serotype
RT M1 group A Streptococcus involved multiple horizontal gene transfer
RT events.";
RL J. Infect. Dis. 192:771-782(2005).
RN [3]
RP SEQUENCE REVISION.
RA Beres S.B., Musser J.M.;
RL Submitted (APR-2014) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Transport of potassium into the cell. {ECO:0000255|HAMAP-
CC Rule:MF_01522}.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000255|HAMAP-Rule:MF_01522};
CC Multi-pass membrane protein {ECO:0000255|HAMAP-Rule:MF_01522}.
CC -!- SIMILARITY: Belongs to the HAK/KUP transporter (TC 2.A.72) family.
CC {ECO:0000255|HAMAP-Rule:MF_01522}.
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DR EMBL; AE004092; AAK34228.1; -; Genomic_DNA.
DR EMBL; CP000017; AAZ51770.2; -; Genomic_DNA.
DR RefSeq; NP_269507.1; NC_002737.2.
DR AlphaFoldDB; Q99Z39; -.
DR STRING; 1314.HKU360_01188; -.
DR PaxDb; Q99Z39; -.
DR EnsemblBacteria; AAK34228; AAK34228; SPy_1414.
DR KEGG; spy:SPy_1414; -.
DR KEGG; spz:M5005_Spy1152; -.
DR PATRIC; fig|160490.10.peg.1232; -.
DR HOGENOM; CLU_008142_4_1_9; -.
DR OMA; AADQFEI; -.
DR Proteomes; UP000000750; Chromosome.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0015079; F:potassium ion transmembrane transporter activity; IEA:UniProtKB-UniRule.
DR HAMAP; MF_01522; Kup; 1.
DR InterPro; IPR003855; K+_transporter.
DR InterPro; IPR023051; K+_uptake_low_affin.
DR PANTHER; PTHR30540; PTHR30540; 1.
DR Pfam; PF02705; K_trans; 1.
PE 3: Inferred from homology;
KW Cell membrane; Ion transport; Membrane; Potassium; Potassium transport;
KW Reference proteome; Transmembrane; Transmembrane helix; Transport.
FT CHAIN 1..666
FT /note="Probable potassium transport system protein kup"
FT /id="PRO_0000209061"
FT TRANSMEM 16..36
FT /note="Helical"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01522"
FT TRANSMEM 58..78
FT /note="Helical"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01522"
FT TRANSMEM 100..120
FT /note="Helical"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01522"
FT TRANSMEM 141..161
FT /note="Helical"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01522"
FT TRANSMEM 165..185
FT /note="Helical"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01522"
FT TRANSMEM 221..241
FT /note="Helical"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01522"
FT TRANSMEM 253..273
FT /note="Helical"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01522"
FT TRANSMEM 294..314
FT /note="Helical"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01522"
FT TRANSMEM 343..363
FT /note="Helical"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01522"
FT TRANSMEM 373..393
FT /note="Helical"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01522"
FT TRANSMEM 399..419
FT /note="Helical"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01522"
FT TRANSMEM 424..444
FT /note="Helical"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01522"
SQ SEQUENCE 666 AA; 74607 MW; DB00703D7F6A1551 CRC64;
MSDSHLTAFD KASKAGFIIA LGIVYGDIGT SPLYTIQSLV ENQGGVNQVS ESFILGSISL
IIWTLTLITT IKYVLIALKA DNHHEGGIFS LFTLVRKMSP WLIIPAMIGG ATLLSDGALT
PAVTVTSAIE GLKAVPGLSH IYQNQTNVII TTLVILIVLF GIQRFGTGFI GKIFGPVMFI
WFSFLGVSGF FNTLGHLEIF KAINPYYALH LLFSPENHRG IFILGSIFLA TTGAEALYSD
LGHVGRGNIY VSWPFVKMCI VLSYCGQAAW ILANKHSGIE LNPFFASVPS QLRVYLVSLA
TLAAIIASQA LISGSFTLVS EAMRLKIFPL FRVTYPGANL GQLYIPVINW ILFAVTSCTV
LAFRTSAHME AAYGLAITIT MLMTTILLKY YLIKKGTRPI LAHLVMAFFA LVEFIFFLAS
AIKFMHGGYA VVILALAIVF VMFIWHAGTR IVFKYVKSLN LNDYKEQIKQ LRDDVCFDLY
QTNVVYLSNR MQDHMIDRSI LYSILDKRPK RAQVYWFVNV QVTDEPYTAK YKVDMMGTDY
MVRVNLYLGF RMPQTVPRYL RTIVQDLMES GRLPKQEQEY TITPGRDVGD FRFVLIEERV
SNARQLSNFE RFIMQTKASI KHVTASPMRW FGLQYSEVTL EVVPLILSDV LKLPIKELVP
VEDSEA
