ID   KUP_STRP3               Reviewed;         666 AA.
AC   P0DB56; Q79XJ5; Q8K6Y2;
DT   27-JUL-2011, integrated into UniProtKB/Swiss-Prot.
DT   27-JUL-2011, sequence version 1.
DT   25-MAY-2022, entry version 42.
DE   RecName: Full=Probable potassium transport system protein kup {ECO:0000255|HAMAP-Rule:MF_01522};
GN   Name=kup {ECO:0000255|HAMAP-Rule:MF_01522}; OrderedLocusNames=SpyM3_1078;
OS   Streptococcus pyogenes serotype M3 (strain ATCC BAA-595 / MGAS315).
OC   Bacteria; Firmicutes; Bacilli; Lactobacillales; Streptococcaceae;
OC   Streptococcus.
OX   NCBI_TaxID=198466;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC BAA-595 / MGAS315;
RX   PubMed=12122206; DOI=10.1073/pnas.152298499;
RA   Beres S.B., Sylva G.L., Barbian K.D., Lei B., Hoff J.S., Mammarella N.D.,
RA   Liu M.-Y., Smoot J.C., Porcella S.F., Parkins L.D., Campbell D.S.,
RA   Smith T.M., McCormick J.K., Leung D.Y.M., Schlievert P.M., Musser J.M.;
RT   "Genome sequence of a serotype M3 strain of group A Streptococcus: phage-
RT   encoded toxins, the high-virulence phenotype, and clone emergence.";
RL   Proc. Natl. Acad. Sci. U.S.A. 99:10078-10083(2002).
CC   -!- FUNCTION: Transport of potassium into the cell. {ECO:0000255|HAMAP-
CC       Rule:MF_01522}.
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000255|HAMAP-Rule:MF_01522};
CC       Multi-pass membrane protein {ECO:0000255|HAMAP-Rule:MF_01522}.
CC   -!- SIMILARITY: Belongs to the HAK/KUP transporter (TC 2.A.72) family.
CC       {ECO:0000255|HAMAP-Rule:MF_01522}.
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DR   EMBL; AE014074; AAM79685.1; -; Genomic_DNA.
DR   RefSeq; WP_011054663.1; NC_004070.1.
DR   AlphaFoldDB; P0DB56; -.
DR   EnsemblBacteria; AAM79685; AAM79685; SpyM3_1078.
DR   KEGG; spg:SpyM3_1078; -.
DR   HOGENOM; CLU_008142_4_1_9; -.
DR   OMA; AADQFEI; -.
DR   Proteomes; UP000000564; Chromosome.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0015079; F:potassium ion transmembrane transporter activity; IEA:UniProtKB-UniRule.
DR   HAMAP; MF_01522; Kup; 1.
DR   InterPro; IPR003855; K+_transporter.
DR   InterPro; IPR023051; K+_uptake_low_affin.
DR   PANTHER; PTHR30540; PTHR30540; 1.
DR   Pfam; PF02705; K_trans; 1.
PE   3: Inferred from homology;
KW   Cell membrane; Ion transport; Membrane; Potassium; Potassium transport;
KW   Transmembrane; Transmembrane helix; Transport.
FT   CHAIN           1..666
FT                   /note="Probable potassium transport system protein kup"
FT                   /id="PRO_0000209062"
FT   TRANSMEM        16..36
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01522"
FT   TRANSMEM        58..78
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01522"
FT   TRANSMEM        100..120
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01522"
FT   TRANSMEM        149..169
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01522"
FT   TRANSMEM        173..193
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01522"
FT   TRANSMEM        221..241
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01522"
FT   TRANSMEM        253..273
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01522"
FT   TRANSMEM        294..314
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01522"
FT   TRANSMEM        343..363
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01522"
FT   TRANSMEM        373..393
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01522"
FT   TRANSMEM        399..419
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01522"
FT   TRANSMEM        424..444
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01522"
SQ   SEQUENCE   666 AA;  74655 MW;  492422A080E7D74A CRC64;
     MSDSHLTAFD KASKAGFIIA LGIVYGDIGT SPLYTMQSLV ENQGGVNQVS ESFILGSISL
     IIWTLTLITT IKYVLIALKA DNHHEGGIFS LFTLVRKMSP WLIVPAMIGG ATLLSDGALT
     PAVTVTSAIE GLKAVPGLSH IYQNQTNVII TTLVILIVLF GIQRFGTGFI GKIFGPVMFI
     WFSFLGVSGF FNMLGHLEIF KAINPYYALH LLFSPENHRG IFILGSIFLA TTGAEALYSD
     LGHVGRGNIY VSWPFVKMCI VLSYCGQAAW ILANKHSGIE LNPFFASVPS QLRVYLVSLA
     TLAAIIASQA LISGSFTLVS EAMRLKIFPL FRVTYPGANL GQLYIPVINW ILFAVTSCTV
     LAFRTSAHME AAYGLAITIT MLMTTILLKY YLIKKGTRPI LAHLVMAFFA LVEFIFFLAS
     AIKFMHGGYA VVILALAIVF VMFIWHAGTR IVFKYVKSLN LNDYKEQIKQ LRDDVCFDLY
     QTNVVYLSNR MQDHMIDRSI LYSILDKRPK RAQVYWFVNV QVTDEPYTAK YKVDMMGTDY
     MVRVNLYLGF RMPQTVPRYL RTIVQDLMES GRLPKQEQEY TITPGRDVGD FRFVLIEERV
     SNARQLSNFE RFIMQTKASI KHVTASPMRW FGLQYSEVTL EVVPLILSDI LKLPIKELVP
     VEDSEA