ID   KUP_STRPG               Reviewed;         666 AA.
AC   A2RDW5;
DT   24-JUL-2007, integrated into UniProtKB/Swiss-Prot.
DT   06-MAR-2007, sequence version 1.
DT   25-MAY-2022, entry version 75.
DE   RecName: Full=Probable potassium transport system protein kup {ECO:0000255|HAMAP-Rule:MF_01522};
GN   Name=kup {ECO:0000255|HAMAP-Rule:MF_01522}; OrderedLocusNames=SpyM50707;
OS   Streptococcus pyogenes serotype M5 (strain Manfredo).
OC   Bacteria; Firmicutes; Bacilli; Lactobacillales; Streptococcaceae;
OC   Streptococcus.
OX   NCBI_TaxID=160491;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Manfredo;
RX   PubMed=17012393; DOI=10.1128/jb.01227-06;
RA   Holden M.T.G., Scott A., Cherevach I., Chillingworth T., Churcher C.,
RA   Cronin A., Dowd L., Feltwell T., Hamlin N., Holroyd S., Jagels K.,
RA   Moule S., Mungall K., Quail M.A., Price C., Rabbinowitsch E., Sharp S.,
RA   Skelton J., Whitehead S., Barrell B.G., Kehoe M., Parkhill J.;
RT   "Complete genome of acute rheumatic fever-associated serotype M5
RT   Streptococcus pyogenes strain Manfredo.";
RL   J. Bacteriol. 189:1473-1477(2007).
CC   -!- FUNCTION: Transport of potassium into the cell. {ECO:0000255|HAMAP-
CC       Rule:MF_01522}.
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000255|HAMAP-Rule:MF_01522};
CC       Multi-pass membrane protein {ECO:0000255|HAMAP-Rule:MF_01522}.
CC   -!- SIMILARITY: Belongs to the HAK/KUP transporter (TC 2.A.72) family.
CC       {ECO:0000255|HAMAP-Rule:MF_01522}.
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DR   EMBL; AM295007; CAM30040.1; -; Genomic_DNA.
DR   RefSeq; WP_011888791.1; NC_009332.1.
DR   AlphaFoldDB; A2RDW5; -.
DR   KEGG; spf:SpyM50707; -.
DR   HOGENOM; CLU_008142_4_1_9; -.
DR   OMA; AADQFEI; -.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0015079; F:potassium ion transmembrane transporter activity; IEA:UniProtKB-UniRule.
DR   HAMAP; MF_01522; Kup; 1.
DR   InterPro; IPR003855; K+_transporter.
DR   InterPro; IPR023051; K+_uptake_low_affin.
DR   PANTHER; PTHR30540; PTHR30540; 1.
DR   Pfam; PF02705; K_trans; 1.
PE   3: Inferred from homology;
KW   Cell membrane; Ion transport; Membrane; Potassium; Potassium transport;
KW   Transmembrane; Transmembrane helix; Transport.
FT   CHAIN           1..666
FT                   /note="Probable potassium transport system protein kup"
FT                   /id="PRO_0000296769"
FT   TRANSMEM        16..36
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01522"
FT   TRANSMEM        58..78
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01522"
FT   TRANSMEM        100..120
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01522"
FT   TRANSMEM        141..161
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01522"
FT   TRANSMEM        165..185
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01522"
FT   TRANSMEM        221..241
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01522"
FT   TRANSMEM        253..273
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01522"
FT   TRANSMEM        292..312
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01522"
FT   TRANSMEM        343..363
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01522"
FT   TRANSMEM        373..393
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01522"
FT   TRANSMEM        399..419
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01522"
FT   TRANSMEM        424..444
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01522"
SQ   SEQUENCE   666 AA;  74836 MW;  270DA2D0B12B8521 CRC64;
     MSDSHLTAFD KASKAGFIIA LGIVYGDIGT SPLYTMQSLV ENQGGVNQVS ESFILGSISL
     IIWTLTLITT IKYVLIALKA DNHHEGGIFS LFTLVRKMSP WLIIPAMIGG ATLLSDGALT
     PAVTVTSAIE GLKAVPGLSH IYQNQTNVII TTLVILIVLF GIQRFGTGFI GKIFGPVMFI
     WFSFLGVSGF FNTLGHLEIF KAINPYYALH LLFSPENHRG IFILGSIFLA TTGAEALYSD
     LGHVGRGNIY VSWPFVKMCI VLSYCGQAAW ILANKHSGIE LNPFFASVPS QLTVYVVILA
     TLAAIIASQA LISGSFTLVS EAMRLKIFPL FRVTYPGANL GQLYIPVINW ILFAVTSCTV
     LYFRTSAHME AAYGLAITIT MLMTTILLNY YLIKEGVKPF LAHLVMTFFA LVEFIFFWAS
     AVKFMHGGYV VVILALAIVF VMFIWHAGTR IVFKYVKSLN LNDYKEQIKQ LRDDVCFDLY
     QTNVVYLSNR MQDYMIDRSI LYSILDKRPK RARVYWFVNV QVTDEPYTAK YKVDMMGTDY
     MVRVNLYLGF RMPQTVPRYL RTIVQDLMES GRLPKQEQEY TITPGRDVGD FRFVLIEERV
     SNARQLSNFE RFIMQTKASI KHVTASPMRW FGLQYSEVTL EVVPLILSDV LKLPIKELVP
     VEDSEA