ID   KUP_STRPM               Reviewed;         666 AA.
AC   Q48SQ3;
DT   06-MAR-2007, integrated into UniProtKB/Swiss-Prot.
DT   13-SEP-2005, sequence version 1.
DT   25-MAY-2022, entry version 81.
DE   RecName: Full=Probable potassium transport system protein kup {ECO:0000255|HAMAP-Rule:MF_01522};
GN   Name=kup {ECO:0000255|HAMAP-Rule:MF_01522}; OrderedLocusNames=M28_Spy1147;
OS   Streptococcus pyogenes serotype M28 (strain MGAS6180).
OC   Bacteria; Firmicutes; Bacilli; Lactobacillales; Streptococcaceae;
OC   Streptococcus.
OX   NCBI_TaxID=319701;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=MGAS6180;
RX   PubMed=16088825; DOI=10.1086/430618;
RA   Green N.M., Zhang S., Porcella S.F., Nagiec M.J., Barbian K.D., Beres S.B.,
RA   Lefebvre R.B., Musser J.M.;
RT   "Genome sequence of a serotype M28 strain of group A Streptococcus:
RT   potential new insights into puerperal sepsis and bacterial disease
RT   specificity.";
RL   J. Infect. Dis. 192:760-770(2005).
CC   -!- FUNCTION: Transport of potassium into the cell. {ECO:0000255|HAMAP-
CC       Rule:MF_01522}.
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000255|HAMAP-Rule:MF_01522};
CC       Multi-pass membrane protein {ECO:0000255|HAMAP-Rule:MF_01522}.
CC   -!- SIMILARITY: Belongs to the HAK/KUP transporter (TC 2.A.72) family.
CC       {ECO:0000255|HAMAP-Rule:MF_01522}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; CP000056; AAX72257.1; -; Genomic_DNA.
DR   RefSeq; WP_011284942.1; NC_007296.2.
DR   AlphaFoldDB; Q48SQ3; -.
DR   EnsemblBacteria; AAX72257; AAX72257; M28_Spy1147.
DR   KEGG; spb:M28_Spy1147; -.
DR   HOGENOM; CLU_008142_4_1_9; -.
DR   OMA; AADQFEI; -.
DR   Proteomes; UP000009292; Chromosome.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0015079; F:potassium ion transmembrane transporter activity; IEA:UniProtKB-UniRule.
DR   HAMAP; MF_01522; Kup; 1.
DR   InterPro; IPR003855; K+_transporter.
DR   InterPro; IPR023051; K+_uptake_low_affin.
DR   PANTHER; PTHR30540; PTHR30540; 1.
DR   Pfam; PF02705; K_trans; 1.
PE   3: Inferred from homology;
KW   Cell membrane; Ion transport; Membrane; Potassium; Potassium transport;
KW   Transmembrane; Transmembrane helix; Transport.
FT   CHAIN           1..666
FT                   /note="Probable potassium transport system protein kup"
FT                   /id="PRO_0000279837"
FT   TRANSMEM        16..36
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01522"
FT   TRANSMEM        58..78
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01522"
FT   TRANSMEM        98..118
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01522"
FT   TRANSMEM        141..161
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01522"
FT   TRANSMEM        165..185
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01522"
FT   TRANSMEM        221..241
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01522"
FT   TRANSMEM        253..273
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01522"
FT   TRANSMEM        299..319
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01522"
FT   TRANSMEM        343..363
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01522"
FT   TRANSMEM        373..393
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01522"
FT   TRANSMEM        399..419
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01522"
FT   TRANSMEM        424..444
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01522"
SQ   SEQUENCE   666 AA;  74607 MW;  5EA1C4B641F378C9 CRC64;
     MSDSHLTAFD KASKAGFIIA LGIVYGDIGT SPLYTMQSLV ENQGGVNQVS ESFILGSISL
     IIWTLTLITT IKYVLIALKA DNHHEGGIFS LFTLVRKISP WLIIPAMIGG ATLLSDGALT
     PAVTVTSAIE GLKAVPGLSH IYQNQTNVII TTLVILIVLF GIQRFGTGFI GKIFGPVMFI
     WFSFLGVSGF FNTLGHLEIF KAINPYYALH LLFSPENHRG IFILGSIFLA TTGAEALYSD
     LGHVGRGNIY VSWPFVKMCI VLSYCGQAAW ILANKHSGIE LNPFFASVPS QLRVYLVSLA
     TLAAIIASQA LISGSFTLIS EAMRLKIFPL FRVTYPGANL GQLYIPVINW ILFAVTSCTV
     LAFRTSAHME AAYGLAITIT MLMTTILLKY YLIKKGTRPI LAHLAMAFFA LVEFIFFLAS
     AIKFMHGGYA VVILALAIVF VMFIWHAGTR IVFKYVKSLN LNDYKEQIKQ LRDDVCFDLY
     QTNVVYLSNR MQDHMIDRSI LYSILDKRPK RAQVYWFVNV QVTDEPYTAK YKVDMMGTDY
     MVRVNLYLGF RMPQTVPRYL RTIVQDLMES GRLPKQEQEY TITPGRDVGD FRFVLIEERV
     TNARQLSNFE RFIMQTKASI KHVTASPMRW FGLQYSEVTL EVVPLILSDV LKLPIKELVP
     VEDSEA