ID   KUP_VIBC3               Reviewed;         620 AA.
AC   A5F0D8; C3M666;
DT   20-MAY-2008, integrated into UniProtKB/Swiss-Prot.
DT   12-JUN-2007, sequence version 1.
DT   25-MAY-2022, entry version 71.
DE   RecName: Full=Probable potassium transport system protein kup {ECO:0000255|HAMAP-Rule:MF_01522};
GN   Name=kup {ECO:0000255|HAMAP-Rule:MF_01522};
GN   OrderedLocusNames=VC0395_0462, VC395_A0795;
OS   Vibrio cholerae serotype O1 (strain ATCC 39541 / Classical Ogawa 395 /
OS   O395).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Vibrionales; Vibrionaceae;
OC   Vibrio.
OX   NCBI_TaxID=345073;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 39541 / Classical Ogawa 395 / O395;
RA   Heidelberg J.;
RL   Submitted (MAR-2007) to the EMBL/GenBank/DDBJ databases.
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 39541 / Classical Ogawa 395 / O395;
RX   PubMed=19115014; DOI=10.1371/journal.pone.0004053;
RA   Feng L., Reeves P.R., Lan R., Ren Y., Gao C., Zhou Z., Ren Y., Cheng J.,
RA   Wang W., Wang J., Qian W., Li D., Wang L.;
RT   "A recalibrated molecular clock and independent origins for the cholera
RT   pandemic clones.";
RL   PLoS ONE 3:E4053-E4053(2008).
CC   -!- FUNCTION: Transport of potassium into the cell. {ECO:0000255|HAMAP-
CC       Rule:MF_01522}.
CC   -!- SUBCELLULAR LOCATION: Cell inner membrane {ECO:0000255|HAMAP-
CC       Rule:MF_01522}; Multi-pass membrane protein {ECO:0000255|HAMAP-
CC       Rule:MF_01522}.
CC   -!- SIMILARITY: Belongs to the HAK/KUP transporter (TC 2.A.72) family.
CC       {ECO:0000255|HAMAP-Rule:MF_01522}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; CP000626; ABQ18390.1; -; Genomic_DNA.
DR   EMBL; CP001236; ACP11629.1; -; Genomic_DNA.
DR   RefSeq; WP_000801195.1; NZ_JAACZH010000019.1.
DR   AlphaFoldDB; A5F0D8; -.
DR   STRING; 345073.VC395_A0795; -.
DR   EnsemblBacteria; ABQ18390; ABQ18390; VC0395_0462.
DR   KEGG; vco:VC0395_0462; -.
DR   KEGG; vcr:VC395_A0795; -.
DR   PATRIC; fig|345073.21.peg.3527; -.
DR   eggNOG; COG3158; Bacteria.
DR   HOGENOM; CLU_008142_4_2_6; -.
DR   OMA; AADQFEI; -.
DR   Proteomes; UP000000249; Chromosome 1.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0015079; F:potassium ion transmembrane transporter activity; IEA:UniProtKB-UniRule.
DR   HAMAP; MF_01522; Kup; 1.
DR   InterPro; IPR003855; K+_transporter.
DR   InterPro; IPR023051; K+_uptake_low_affin.
DR   PANTHER; PTHR30540; PTHR30540; 1.
DR   Pfam; PF02705; K_trans; 1.
PE   3: Inferred from homology;
KW   Cell inner membrane; Cell membrane; Ion transport; Membrane; Potassium;
KW   Potassium transport; Transmembrane; Transmembrane helix; Transport.
FT   CHAIN           1..620
FT                   /note="Probable potassium transport system protein kup"
FT                   /id="PRO_1000087562"
FT   TRANSMEM        11..31
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01522"
FT   TRANSMEM        51..71
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01522"
FT   TRANSMEM        100..120
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01522"
FT   TRANSMEM        138..158
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01522"
FT   TRANSMEM        167..187
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01522"
FT   TRANSMEM        202..222
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01522"
FT   TRANSMEM        246..266
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01522"
FT   TRANSMEM        288..308
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01522"
FT   TRANSMEM        334..354
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01522"
FT   TRANSMEM        364..384
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01522"
FT   TRANSMEM        396..416
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01522"
FT   TRANSMEM        418..438
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01522"
SQ   SEQUENCE   620 AA;  69048 MW;  F97322A8AD465053 CRC64;
     MKPAKQTTAS LAFLAMGIVY GDIGTSPLYA FKEVFFSHHP LAINPDNVLG ILSLVFWAFV
     LIVSIKYLLL VTRADQNGEG GILTLSAIAQ QNAPKPWRRI AMLLGILATG FFFGEAVITP
     AMSVLSAVEG IAVAQPDLAP YVLPIAMMII VALFAVQAMG TERIGRFFAP VMLLWFLVLA
     LLGAHAIWHA PQVLRALNPA YAVHFVLLHG QHTLFILGLV VLSVTGVEAL YADMGHFGIK
     PIRIAWFALV MPSLLLNYFG QGAYLLTLSA PTGSTFFSLA PKAWLWPLIL LATFATVIAS
     QAVISGIFSL ARQAINYGYL PPMKIAHTSE HSQGQIYVPA ANMLLFVAVI FVMLRFRSSA
     NLAAAYGIAV TAIMMISSLL LVLVARYQWQ WRWPRVVTIG IAFIGMDTLL LASTSTKLME
     GGWLPLLLGC VVFIVMYIWQ QQRQRLLEIA GNELSVSAMI QSLEEESFQR AAGTAVYLSR
     SLNHVPRSLL HNIKYNKTLH ERNVLMTFQY EAVPRVHPCR RAEIEQVSAS FWQVVIHIGY
     QEEPDMAQVM HCCGLKGLYL HPNETLFLLS SERLKVQKLG MWHDLKVWFF IQMSKHALRT
     SERLNIPPDR LIEMGVYREM