ID   KUP_VIBCH               Reviewed;         620 AA.
AC   Q9KM59;
DT   27-SEP-2004, integrated into UniProtKB/Swiss-Prot.
DT   01-OCT-2000, sequence version 1.
DT   03-AUG-2022, entry version 92.
DE   RecName: Full=Probable potassium transport system protein kup {ECO:0000255|HAMAP-Rule:MF_01522};
GN   Name=kup {ECO:0000255|HAMAP-Rule:MF_01522}; OrderedLocusNames=VC_A0529;
OS   Vibrio cholerae serotype O1 (strain ATCC 39315 / El Tor Inaba N16961).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Vibrionales; Vibrionaceae;
OC   Vibrio.
OX   NCBI_TaxID=243277;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 39315 / El Tor Inaba N16961;
RX   PubMed=10952301; DOI=10.1038/35020000;
RA   Heidelberg J.F., Eisen J.A., Nelson W.C., Clayton R.A., Gwinn M.L.,
RA   Dodson R.J., Haft D.H., Hickey E.K., Peterson J.D., Umayam L.A., Gill S.R.,
RA   Nelson K.E., Read T.D., Tettelin H., Richardson D.L., Ermolaeva M.D.,
RA   Vamathevan J.J., Bass S., Qin H., Dragoi I., Sellers P., McDonald L.A.,
RA   Utterback T.R., Fleischmann R.D., Nierman W.C., White O., Salzberg S.L.,
RA   Smith H.O., Colwell R.R., Mekalanos J.J., Venter J.C., Fraser C.M.;
RT   "DNA sequence of both chromosomes of the cholera pathogen Vibrio
RT   cholerae.";
RL   Nature 406:477-483(2000).
CC   -!- FUNCTION: Transport of potassium into the cell. {ECO:0000255|HAMAP-
CC       Rule:MF_01522}.
CC   -!- SUBCELLULAR LOCATION: Cell inner membrane {ECO:0000255|HAMAP-
CC       Rule:MF_01522}; Multi-pass membrane protein {ECO:0000255|HAMAP-
CC       Rule:MF_01522}.
CC   -!- SIMILARITY: Belongs to the HAK/KUP transporter (TC 2.A.72) family.
CC       {ECO:0000255|HAMAP-Rule:MF_01522}.
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DR   EMBL; AE003853; AAF96432.1; -; Genomic_DNA.
DR   PIR; F82449; F82449.
DR   RefSeq; NP_232920.1; NC_002506.1.
DR   RefSeq; WP_000801198.1; NZ_LT906615.1.
DR   AlphaFoldDB; Q9KM59; -.
DR   STRING; 243277.VC_A0529; -.
DR   DNASU; 2612710; -.
DR   EnsemblBacteria; AAF96432; AAF96432; VC_A0529.
DR   KEGG; vch:VC_A0529; -.
DR   PATRIC; fig|243277.26.peg.3154; -.
DR   eggNOG; COG3158; Bacteria.
DR   HOGENOM; CLU_008142_4_2_6; -.
DR   OMA; AADQFEI; -.
DR   BioCyc; VCHO:VCA0529-MON; -.
DR   Proteomes; UP000000584; Chromosome 2.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0016020; C:membrane; IBA:GO_Central.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0015079; F:potassium ion transmembrane transporter activity; IBA:GO_Central.
DR   GO; GO:0006813; P:potassium ion transport; IBA:GO_Central.
DR   HAMAP; MF_01522; Kup; 1.
DR   InterPro; IPR003855; K+_transporter.
DR   InterPro; IPR023051; K+_uptake_low_affin.
DR   PANTHER; PTHR30540; PTHR30540; 1.
DR   Pfam; PF02705; K_trans; 1.
PE   3: Inferred from homology;
KW   Cell inner membrane; Cell membrane; Ion transport; Membrane; Potassium;
KW   Potassium transport; Reference proteome; Transmembrane;
KW   Transmembrane helix; Transport.
FT   CHAIN           1..620
FT                   /note="Probable potassium transport system protein kup"
FT                   /id="PRO_0000209066"
FT   TRANSMEM        11..31
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01522"
FT   TRANSMEM        51..71
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01522"
FT   TRANSMEM        100..120
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01522"
FT   TRANSMEM        138..158
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01522"
FT   TRANSMEM        167..187
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01522"
FT   TRANSMEM        202..222
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01522"
FT   TRANSMEM        246..266
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01522"
FT   TRANSMEM        288..308
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01522"
FT   TRANSMEM        334..354
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01522"
FT   TRANSMEM        364..384
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01522"
FT   TRANSMEM        396..416
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01522"
FT   TRANSMEM        418..438
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01522"
SQ   SEQUENCE   620 AA;  69033 MW;  840973C674E141C9 CRC64;
     MKPAKQTTAS LAFLAMGIVY GDIGTSPLYA FKEVFFSHHP LAINPDNVLG ILSLVFWAFV
     LIVSIKYLLL VTRADQNGEG GILTLSAIAQ QSAPKPWQRI AMLLGILATG FFFGEAVITP
     AMSVLSAVEG IAVAQPDLAP YVLPIAMMII VALFAVQAMG TERIGRFFAP VMLLWFLVLA
     LLGAHAIWHA PQVLRALNPA YAVHFVLLYG QHTLFILGLV VLSVTGVEAL YADMGHFGIK
     PIRIAWFALV MPSLLLNYFG QGAYLLTLSA PTGSTFFSLA PKAWLWPLIL LATFATVIAS
     QAVISGIFSL ARQAINYGYL PPMKIAHTSE HSQGQIYVPA ANMLLFVAVI FVMLRFRSSA
     NLAAAYGIAV TAIMMISSLL LVLVARYQWQ WRWPRVVTIG IVFIGMDSLL LASTSTKLME
     GGWLPLLLGC VVFIVMYIWQ QQRQRLLEIA GNELSVSAMI QSLEEESFQR AAGTAVYLSR
     SLNHVPRSLL HNIKYNKTLH ERNVLMTFQY EAVPRVHPCR RAEIEQVSAS FWQVVIHIGY
     QEEPDMAQVM HCCGLKGLYL HPNETLFLLS SERLKVQKLG MWHDLKVWFF IQMSKHALRT
     SERLNIPPDR LIEMGVYREM