KUP_WIGBR
ID KUP_WIGBR Reviewed; 625 AA.
AC Q8D1U8;
DT 27-SEP-2004, integrated into UniProtKB/Swiss-Prot.
DT 01-MAR-2003, sequence version 1.
DT 25-MAY-2022, entry version 80.
DE RecName: Full=Low affinity potassium transport system protein kup {ECO:0000255|HAMAP-Rule:MF_01522};
DE AltName: Full=Kup system potassium uptake protein {ECO:0000255|HAMAP-Rule:MF_01522};
GN Name=kup {ECO:0000255|HAMAP-Rule:MF_01522}; OrderedLocusNames=WIGBR6080;
OS Wigglesworthia glossinidia brevipalpis.
OC Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC Erwiniaceae; Wigglesworthia.
OX NCBI_TaxID=36870;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=12219091; DOI=10.1038/ng986;
RA Akman L., Yamashita A., Watanabe H., Oshima K., Shiba T., Hattori M.,
RA Aksoy S.;
RT "Genome sequence of the endocellular obligate symbiont of tsetse flies,
RT Wigglesworthia glossinidia.";
RL Nat. Genet. 32:402-407(2002).
CC -!- FUNCTION: Responsible for the low-affinity transport of potassium into
CC the cell, with the probable concomitant uptake of protons (symport
CC system). {ECO:0000255|HAMAP-Rule:MF_01522}.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000255|HAMAP-Rule:MF_01522};
CC Multi-pass membrane protein {ECO:0000255|HAMAP-Rule:MF_01522}.
CC -!- SIMILARITY: Belongs to the HAK/KUP transporter (TC 2.A.72) family.
CC {ECO:0000255|HAMAP-Rule:MF_01522}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; BA000021; BAC24754.1; -; Genomic_DNA.
DR AlphaFoldDB; Q8D1U8; -.
DR STRING; 36870.25166564; -.
DR EnsemblBacteria; BAC24754; BAC24754; BAC24754.
DR KEGG; wbr:kup; -.
DR eggNOG; COG3158; Bacteria.
DR HOGENOM; CLU_008142_4_2_6; -.
DR OMA; AADQFEI; -.
DR Proteomes; UP000000562; Chromosome.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0015079; F:potassium ion transmembrane transporter activity; IEA:UniProtKB-UniRule.
DR GO; GO:0015293; F:symporter activity; IEA:UniProtKB-UniRule.
DR HAMAP; MF_01522; Kup; 1.
DR InterPro; IPR003855; K+_transporter.
DR InterPro; IPR023051; K+_uptake_low_affin.
DR PANTHER; PTHR30540; PTHR30540; 1.
DR Pfam; PF02705; K_trans; 1.
PE 3: Inferred from homology;
KW Cell membrane; Ion transport; Membrane; Potassium; Potassium transport;
KW Reference proteome; Symport; Transmembrane; Transmembrane helix; Transport.
FT CHAIN 1..625
FT /note="Low affinity potassium transport system protein kup"
FT /id="PRO_0000209067"
FT TOPO_DOM 1..12
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 13..35
FT /note="Helical"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01522"
FT TOPO_DOM 36..49
FT /note="Periplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 50..72
FT /note="Helical"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01522"
FT TOPO_DOM 73..100
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 101..123
FT /note="Helical"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01522"
FT TOPO_DOM 124..137
FT /note="Periplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 138..160
FT /note="Helical"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01522"
FT TOPO_DOM 161..172
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 173..195
FT /note="Helical"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01522"
FT TOPO_DOM 196..214
FT /note="Periplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 215..237
FT /note="Helical"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01522"
FT TOPO_DOM 238..249
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 250..272
FT /note="Helical"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01522"
FT TOPO_DOM 273..291
FT /note="Periplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 292..314
FT /note="Helical"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01522"
FT TOPO_DOM 315..339
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 340..357
FT /note="Helical"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01522"
FT TOPO_DOM 358..366
FT /note="Periplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 367..389
FT /note="Helical"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01522"
FT TOPO_DOM 390..395
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 396..415
FT /note="Helical"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01522"
FT TOPO_DOM 416..429
FT /note="Periplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 430..452
FT /note="Helical"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01522"
FT TOPO_DOM 453..625
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
SQ SEQUENCE 625 AA; 72591 MW; 253E4632B9B4CABC CRC64;
MNMIKKNKKK SFLCTIFSTI NVLHGLIAIS PIYIIKESFV NNLGFKIDKL AIFGILSIIF
WTLFFIIFLK YLILIVSINN SGEGGILTLM SITAKKINSK STFVIVILGL ISMCLFFGDI
IIIPSISIIS VIEEISIYYL SFEKFIFIIS IAIFTFLFFI QKKIKNEFNN IFSFLISIWF
ILVGLIGLKG IYINPEILLA INPKYLINFF KHYKLNAFFV FGTLILLISI SEILYINIGR
FSKLEIRKSW LFFVFPMIMI NCFGQGSIIL LYPESISHPF FFLVPDWARF FTFTFAIIIS
IISSQNIISS IFYLTRQAVR LGYLPNIKIF YTSEVKSRRI YIPCINWIFY LSAVIQISIF
KNLHNLILIY GIGSIITMSL TTFFSLLFFK KKFEKFKILK ITFLLTILIL EFFIFISNSY
KIICGGWFPI VFGIIFFTIM ITWKVETFNL LLHTHNNSNS IKLFIKNLRK NNLLKVNGTS
VFMSSMDNTI PLSIIHNIKH NKVLHEKIIF LNIKTEDSPF IKKECRVEIE KLNNGFWGVK
AYYGFKETPD IKEIFHFCNL LGISLNIMET SFFISHESLI LGKRPWYLAI RAKLFIFLKR
NSLGSTYQYS IPLDRVIALG IQVKI
