ID   KUP_YERE8               Reviewed;         623 AA.
AC   A1JHR6;
DT   26-JUN-2007, integrated into UniProtKB/Swiss-Prot.
DT   26-JUN-2007, sequence version 2.
DT   25-MAY-2022, entry version 73.
DE   RecName: Full=Low affinity potassium transport system protein kup {ECO:0000255|HAMAP-Rule:MF_01522};
DE   AltName: Full=Kup system potassium uptake protein {ECO:0000255|HAMAP-Rule:MF_01522};
GN   Name=kup {ECO:0000255|HAMAP-Rule:MF_01522}; OrderedLocusNames=YE0007;
OS   Yersinia enterocolitica serotype O:8 / biotype 1B (strain NCTC 13174 /
OS   8081).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC   Yersiniaceae; Yersinia.
OX   NCBI_TaxID=393305;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=NCTC 13174 / 8081;
RX   PubMed=17173484; DOI=10.1371/journal.pgen.0020206;
RA   Thomson N.R., Howard S., Wren B.W., Holden M.T.G., Crossman L.,
RA   Challis G.L., Churcher C., Mungall K., Brooks K., Chillingworth T.,
RA   Feltwell T., Abdellah Z., Hauser H., Jagels K., Maddison M., Moule S.,
RA   Sanders M., Whitehead S., Quail M.A., Dougan G., Parkhill J.,
RA   Prentice M.B.;
RT   "The complete genome sequence and comparative genome analysis of the high
RT   pathogenicity Yersinia enterocolitica strain 8081.";
RL   PLoS Genet. 2:2039-2051(2006).
CC   -!- FUNCTION: Responsible for the low-affinity transport of potassium into
CC       the cell, with the probable concomitant uptake of protons (symport
CC       system). {ECO:0000255|HAMAP-Rule:MF_01522}.
CC   -!- SUBCELLULAR LOCATION: Cell inner membrane {ECO:0000255|HAMAP-
CC       Rule:MF_01522}; Multi-pass membrane protein {ECO:0000255|HAMAP-
CC       Rule:MF_01522}.
CC   -!- SIMILARITY: Belongs to the HAK/KUP transporter (TC 2.A.72) family.
CC       {ECO:0000255|HAMAP-Rule:MF_01522}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=CAL10152.1; Type=Erroneous initiation; Evidence={ECO:0000305};
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DR   EMBL; AM286415; CAL10152.1; ALT_INIT; Genomic_DNA.
DR   RefSeq; WP_005175182.1; NC_008800.1.
DR   RefSeq; YP_001004404.1; NC_008800.1.
DR   AlphaFoldDB; A1JHR6; -.
DR   STRING; 393305.YE0007; -.
DR   EnsemblBacteria; CAL10152; CAL10152; YE0007.
DR   KEGG; yen:YE0007; -.
DR   PATRIC; fig|393305.7.peg.96; -.
DR   eggNOG; COG3158; Bacteria.
DR   HOGENOM; CLU_008142_4_2_6; -.
DR   Proteomes; UP000000642; Chromosome.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0015079; F:potassium ion transmembrane transporter activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0015293; F:symporter activity; IEA:UniProtKB-UniRule.
DR   HAMAP; MF_01522; Kup; 1.
DR   InterPro; IPR003855; K+_transporter.
DR   InterPro; IPR023051; K+_uptake_low_affin.
DR   PANTHER; PTHR30540; PTHR30540; 1.
DR   Pfam; PF02705; K_trans; 1.
DR   TIGRFAMs; TIGR00794; kup; 1.
PE   3: Inferred from homology;
KW   Cell inner membrane; Cell membrane; Ion transport; Membrane; Potassium;
KW   Potassium transport; Symport; Transmembrane; Transmembrane helix;
KW   Transport.
FT   CHAIN           1..623
FT                   /note="Low affinity potassium transport system protein kup"
FT                   /id="PRO_0000292621"
FT   TRANSMEM        10..30
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01522"
FT   TRANSMEM        47..67
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01522"
FT   TRANSMEM        102..122
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01522"
FT   TRANSMEM        138..158
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01522"
FT   TRANSMEM        166..186
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01522"
FT   TRANSMEM        214..234
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01522"
FT   TRANSMEM        248..268
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01522"
FT   TRANSMEM        288..310
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01522"
FT   TRANSMEM        338..358
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01522"
FT   TRANSMEM        364..384
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01522"
FT   TRANSMEM        396..416
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01522"
FT   TRANSMEM        420..440
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01522"
SQ   SEQUENCE   623 AA;  68987 MW;  3B0754CCC7726F6A CRC64;
     MSTEHKKQSL SAVTLAAIGV VYGDIGTSPL YTLRECFSGH YGFDVRPDVV FGFLSLIFWM
     LILIVSVKYL TYVMRADNAG EGGILTLMSL AGRNTSSRAT SILVILGLIG GSFFYGEVVI
     TPAISVMSAI EGLEIAAPAL DPYIVPCSIA VLTLLFVIQK HGTGSVGKLF APVMLVWFLT
     LALLGLRSII ANPEVLAALN PKWAISFFTE YKSVSFFALG AVVLAITGVE ALYADMGHFG
     KFPIRLAWFT VVLPSLVLNY FGQGALLLKN PEAIKNPFFL LAPDWALIPL LILATLATVI
     ASQAVISGVF SLTRQAVRLG YLPPMRIIHT SEMESGQIYI PVINWTLYLA VVLVIVGFER
     SSNLAAAYGI AVTGTMVITS VLFCTVALKN WHWNRFFVYF LLVALLVIDV PMFSANALKL
     FSGGWLPLSL GLVMFIIMTT WKSERFSLLR RMHEHGNSLE AMIASLEKSP PVRVPGTAVY
     MSRAMNVIPF ALLHNLKHNK VLHDRVVLLT LRTEDAPYVH NVNRVTIEQL SPTFWRVVAS
     YGWRETPNVE EIFHRCGLEG LPCQMMETSF FMSHESLILT KRPWYLFLRG KLFIALSRNA
     LRAADQFEIP PNRVIELGTQ VEI