ID   KUP_YERPY               Reviewed;         622 AA.
AC   B1JR26;
DT   14-APR-2009, integrated into UniProtKB/Swiss-Prot.
DT   29-APR-2008, sequence version 1.
DT   25-MAY-2022, entry version 68.
DE   RecName: Full=Low affinity potassium transport system protein kup {ECO:0000255|HAMAP-Rule:MF_01522};
DE   AltName: Full=Kup system potassium uptake protein {ECO:0000255|HAMAP-Rule:MF_01522};
GN   Name=kup {ECO:0000255|HAMAP-Rule:MF_01522}; OrderedLocusNames=YPK_4211;
OS   Yersinia pseudotuberculosis serotype O:3 (strain YPIII).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC   Yersiniaceae; Yersinia.
OX   NCBI_TaxID=502800;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=YPIII;
RG   US DOE Joint Genome Institute;
RA   Copeland A., Lucas S., Lapidus A., Glavina del Rio T., Dalin E., Tice H.,
RA   Bruce D., Goodwin L., Pitluck S., Munk A.C., Brettin T., Detter J.C.,
RA   Han C., Tapia R., Schmutz J., Larimer F., Land M., Hauser L.,
RA   Challacombe J.F., Green L., Lindler L.E., Nikolich M.P., Richardson P.;
RT   "Complete sequence of Yersinia pseudotuberculosis YPIII.";
RL   Submitted (FEB-2008) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Responsible for the low-affinity transport of potassium into
CC       the cell, with the probable concomitant uptake of protons (symport
CC       system). {ECO:0000255|HAMAP-Rule:MF_01522}.
CC   -!- SUBCELLULAR LOCATION: Cell inner membrane {ECO:0000255|HAMAP-
CC       Rule:MF_01522}; Multi-pass membrane protein {ECO:0000255|HAMAP-
CC       Rule:MF_01522}.
CC   -!- SIMILARITY: Belongs to the HAK/KUP transporter (TC 2.A.72) family.
CC       {ECO:0000255|HAMAP-Rule:MF_01522}.
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DR   EMBL; CP000950; ACA70467.1; -; Genomic_DNA.
DR   RefSeq; WP_011191440.1; NZ_CP009792.1.
DR   AlphaFoldDB; B1JR26; -.
DR   EnsemblBacteria; ACA70467; ACA70467; YPK_4211.
DR   GeneID; 66843602; -.
DR   KEGG; ypy:YPK_4211; -.
DR   PATRIC; fig|502800.11.peg.561; -.
DR   OMA; AADQFEI; -.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0015079; F:potassium ion transmembrane transporter activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0015293; F:symporter activity; IEA:UniProtKB-UniRule.
DR   HAMAP; MF_01522; Kup; 1.
DR   InterPro; IPR003855; K+_transporter.
DR   InterPro; IPR023051; K+_uptake_low_affin.
DR   PANTHER; PTHR30540; PTHR30540; 1.
DR   Pfam; PF02705; K_trans; 1.
DR   TIGRFAMs; TIGR00794; kup; 1.
PE   3: Inferred from homology;
KW   Cell inner membrane; Cell membrane; Ion transport; Membrane; Potassium;
KW   Potassium transport; Symport; Transmembrane; Transmembrane helix;
KW   Transport.
FT   CHAIN           1..622
FT                   /note="Low affinity potassium transport system protein kup"
FT                   /id="PRO_1000146357"
FT   TRANSMEM        9..29
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01522"
FT   TRANSMEM        46..66
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01522"
FT   TRANSMEM        101..121
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01522"
FT   TRANSMEM        137..157
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01522"
FT   TRANSMEM        165..185
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01522"
FT   TRANSMEM        213..233
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01522"
FT   TRANSMEM        247..267
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01522"
FT   TRANSMEM        287..309
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01522"
FT   TRANSMEM        337..357
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01522"
FT   TRANSMEM        363..383
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01522"
FT   TRANSMEM        395..415
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01522"
FT   TRANSMEM        416..436
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01522"
SQ   SEQUENCE   622 AA;  69012 MW;  4037DE24A56F015A CRC64;
     MSTEHKQSLS AVTLAAIGVV YGDIGTSPLY TLRECFSGHY GFDVRPDVVF GFLSLIFWML
     ILVVSVKYLT YVMRADNAGE GGILTLMSLA GRNTSSRATS ILVVLGLIGG SFFYGEVVIT
     PAISVMSAIE GLEIAAPALD PYIVPCSIAV LTLLFVIQKH GTGSVGKLFA PVMLVWFLTL
     ALLGLRSIIA NPEVLAALNP KWAISFFVEY KSVSFFALGA VVLAITGVEA LYADMGHFGK
     FPIRLAWFTV VLPSLVLNYF GQGALLLKNP EAIKNPFFLL APDWALIPLL ILATLATVIA
     SQAVISGVFS LTRQAVRLGY LPPMRIIHTS EMESGQIYIP VINWTLYLAV VLVIIGFERS
     SNLAAAYGIA VTGTMVITSI LFCTVAWKNW HWNRFLVAFL LMVLLIIDIP MFSANVLKLF
     SGGWLPLSLG LVMFIIMTTW KSERFSLLRR MHEHSNSLEA MIASLEKSPP VRVPGTAVYM
     SRAMNVIPFA LLHNLKHNKV LHERVVLLTM RTDDVPYVHN VERVTIEQLS PTFWRVVARY
     GWRETPNVAE IFHRCGLEGL SCQMMETSFF MSHESLILTK RPWHLFLRGK LFIALSRNAL
     RAPDQFEIPP NRVIELGTQV EI