KU_AZOC5
ID KU_AZOC5 Reviewed; 323 AA.
AC A8HV31;
DT 24-NOV-2009, integrated into UniProtKB/Swiss-Prot.
DT 24-NOV-2009, sequence version 2.
DT 25-MAY-2022, entry version 69.
DE RecName: Full=Non-homologous end joining protein Ku {ECO:0000255|HAMAP-Rule:MF_01875};
GN Name=ku {ECO:0000255|HAMAP-Rule:MF_01875}; OrderedLocusNames=AZC_1005;
OS Azorhizobium caulinodans (strain ATCC 43989 / DSM 5975 / JCM 20966 / LMG
OS 6465 / NBRC 14845 / NCIMB 13405 / ORS 571).
OC Bacteria; Proteobacteria; Alphaproteobacteria; Hyphomicrobiales;
OC Xanthobacteraceae; Azorhizobium.
OX NCBI_TaxID=438753;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 43989 / DSM 5975 / JCM 20966 / LMG 6465 / NBRC 14845 / NCIMB
RC 13405 / ORS 571;
RA Lee K.B., Backer P.D., Aono T., Liu C.T., Suzuki S., Suzuki T., Kaneko T.,
RA Yamada M., Tabata S., Kupfer D.M., Najar F.Z., Wiley G.B., Roe B.,
RA Binnewies T., Ussery D., Vereecke D., Gevers D., Holsters M., Oyaizu H.;
RT "Complete genome sequence of the nitrogen-fixing bacterium Azorhizobium
RT caulinodans ORS571.";
RL Submitted (APR-2007) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: With LigD forms a non-homologous end joining (NHEJ) DNA
CC repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds
CC linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA
CC nor ssDNA. Recruits and stimulates the ligase activity of LigD.
CC {ECO:0000255|HAMAP-Rule:MF_01875}.
CC -!- SUBUNIT: Homodimer. Interacts with LigD. {ECO:0000255|HAMAP-
CC Rule:MF_01875}.
CC -!- SIMILARITY: Belongs to the prokaryotic Ku family. {ECO:0000255|HAMAP-
CC Rule:MF_01875}.
CC -!- SEQUENCE CAUTION:
CC Sequence=BAF87003.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence={ECO:0000305};
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DR EMBL; AP009384; BAF87003.1; ALT_INIT; Genomic_DNA.
DR AlphaFoldDB; A8HV31; -.
DR SMR; A8HV31; -.
DR STRING; 438753.AZC_1005; -.
DR EnsemblBacteria; BAF87003; BAF87003; AZC_1005.
DR KEGG; azc:AZC_1005; -.
DR eggNOG; COG1273; Bacteria.
DR HOGENOM; CLU_048975_0_0_5; -.
DR OrthoDB; 1724780at2; -.
DR Proteomes; UP000000270; Chromosome.
DR GO; GO:0003690; F:double-stranded DNA binding; IEA:UniProtKB-UniRule.
DR GO; GO:0006310; P:DNA recombination; IEA:UniProtKB-KW.
DR GO; GO:0006303; P:double-strand break repair via nonhomologous end joining; IEA:UniProtKB-UniRule.
DR Gene3D; 2.40.290.10; -; 1.
DR HAMAP; MF_01875; Prokaryotic_Ku; 1.
DR InterPro; IPR006164; Ku70/Ku80_beta-barrel_dom.
DR InterPro; IPR009187; Prok_Ku.
DR InterPro; IPR016194; SPOC-like_C_dom_sf.
DR PANTHER; PTHR41251; PTHR41251; 1.
DR Pfam; PF02735; Ku; 1.
DR PIRSF; PIRSF006493; Prok_Ku; 1.
DR SMART; SM00559; Ku78; 1.
DR SUPFAM; SSF100939; SSF100939; 1.
DR TIGRFAMs; TIGR02772; Ku_bact; 1.
PE 3: Inferred from homology;
KW DNA damage; DNA recombination; DNA repair; DNA-binding; Reference proteome.
FT CHAIN 1..323
FT /note="Non-homologous end joining protein Ku"
FT /id="PRO_0000389175"
FT DOMAIN 12..197
FT /note="Ku"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01875"
FT REGION 255..323
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 309..323
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 323 AA; 34397 MW; 990D8E7A483FAD98 CRC64;
MALRASWKGF LTVGALSCHV GLYAAASTSE RISLHMVNRK TGHRLRRQYV DEETGEPVEA
DAQVKGYEVS KGEFVTVEPD EIADIVPAGT KTIAVNTFLA CTDVDTAYFD RPYFLAPVDE
PSAEVLKLLA AGMSERKVAA LGEAVLFRRV RRLLIRPVAE GGALTACTLN FDYEVRSAQE
QFADVPKTRI SGEMLELATH IIRSKPGKFD PSAIEDRYED ALAALVRAKM EGKPLPKPEP
RREEKVVSLL DALRASAGSP DKPAPKRAGA KGKAAGTKTA GSKAGSAKAG GSKATGTKTR
KAKSAAASAG AQTRRTGTTR KAG
