ID   KU_CERSK                Reviewed;         267 AA.
AC   B9KKS1;
DT   24-NOV-2009, integrated into UniProtKB/Swiss-Prot.
DT   24-NOV-2009, sequence version 2.
DT   25-MAY-2022, entry version 58.
DE   RecName: Full=Non-homologous end joining protein Ku {ECO:0000255|HAMAP-Rule:MF_01875};
GN   Name=ku {ECO:0000255|HAMAP-Rule:MF_01875}; OrderedLocusNames=RSKD131_1858;
OS   Cereibacter sphaeroides (strain KD131 / KCTC 12085) (Rhodobacter
OS   sphaeroides).
OC   Bacteria; Proteobacteria; Alphaproteobacteria; Rhodobacterales;
OC   Rhodobacteraceae; Cereibacter.
OX   NCBI_TaxID=557760;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=KD131 / KCTC 12085;
RX   PubMed=19028901; DOI=10.1128/jb.01565-08;
RA   Lim S.-K., Kim S.J., Cha S.H., Oh Y.-K., Rhee H.-J., Kim M.-S., Lee J.K.;
RT   "Complete genome sequence of Rhodobacter sphaeroides KD131.";
RL   J. Bacteriol. 191:1118-1119(2009).
CC   -!- FUNCTION: With LigD forms a non-homologous end joining (NHEJ) DNA
CC       repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds
CC       linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA
CC       nor ssDNA. Recruits and stimulates the ligase activity of LigD.
CC       {ECO:0000255|HAMAP-Rule:MF_01875}.
CC   -!- SUBUNIT: Homodimer. Interacts with LigD. {ECO:0000255|HAMAP-
CC       Rule:MF_01875}.
CC   -!- SIMILARITY: Belongs to the prokaryotic Ku family. {ECO:0000255|HAMAP-
CC       Rule:MF_01875}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=ACM01718.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000305};
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DR   EMBL; CP001150; ACM01718.1; ALT_INIT; Genomic_DNA.
DR   RefSeq; WP_041669644.1; NC_011963.1.
DR   AlphaFoldDB; B9KKS1; -.
DR   SMR; B9KKS1; -.
DR   EnsemblBacteria; ACM01718; ACM01718; RSKD131_1858.
DR   GeneID; 67447256; -.
DR   KEGG; rsk:RSKD131_1858; -.
DR   HOGENOM; CLU_048975_0_1_5; -.
DR   Proteomes; UP000001597; Chromosome 1.
DR   GO; GO:0003690; F:double-stranded DNA binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0006310; P:DNA recombination; IEA:UniProtKB-KW.
DR   GO; GO:0006303; P:double-strand break repair via nonhomologous end joining; IEA:UniProtKB-UniRule.
DR   CDD; cd00789; KU_like; 1.
DR   Gene3D; 2.40.290.10; -; 1.
DR   HAMAP; MF_01875; Prokaryotic_Ku; 1.
DR   InterPro; IPR006164; Ku70/Ku80_beta-barrel_dom.
DR   InterPro; IPR009187; Prok_Ku.
DR   InterPro; IPR016194; SPOC-like_C_dom_sf.
DR   PANTHER; PTHR41251; PTHR41251; 1.
DR   Pfam; PF02735; Ku; 1.
DR   PIRSF; PIRSF006493; Prok_Ku; 1.
DR   SMART; SM00559; Ku78; 1.
DR   SUPFAM; SSF100939; SSF100939; 1.
DR   TIGRFAMs; TIGR02772; Ku_bact; 1.
PE   3: Inferred from homology;
KW   DNA damage; DNA recombination; DNA repair; DNA-binding.
FT   CHAIN           1..267
FT                   /note="Non-homologous end joining protein Ku"
FT                   /id="PRO_0000389194"
FT   DOMAIN          11..195
FT                   /note="Ku"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01875"
FT   REGION          229..267
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   267 AA;  29472 MW;  95B8CC2B253910DD CRC64;
     MPRAIWKGWL AVGQVSCAVA LHAAASTSDR VSFHTVNRKT GNRVRREFVD AVSGKPVPRE
     DQVKGYEVAP DEFVQIDPDE IAATIPDSDK CLRIDAFVPC REVDGAYFDK PYYLTPAGDA
     ALEAFALIRE GMRARKAAAL ARTVLFRRLR TVMVRPHGAG LIAHTLNFDY EVRSSAEAFS
     EIPKLKVKGE MLELAKHIIG TKAGTFDPTA FDDRYDAALA ELVKAKLEGR KPKRKAAPKK
     AREPSDLMAA LRESVAATER PRRRKAG